Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 35896-58-3, name is 1,2,3,4-Tetramethoxy-5-methylbenzene, A new synthetic method of this compound is introduced below., SDS of cas: 35896-58-3
General procedure: A solution of compounds 1, 4, 5 (2.5 mmol) in THF (10 mL) was diluted with water (5 mL), and an excess solution of cerricammonium nitrate (CAN) (3.9 g, 7 mmol) in 10 mL water was added at 0 C. The mixture was stirred at room temperature for 2 h. The progress of the reaction was monitored by TLC. After completion of the reaction, the THF was removed under a vacuum at 40 C, and the crude mixture was extracted with three portions of CH2Cl2 (20 mL). The orange extracts were washed with brine until neutrality, then dried over anhydrous Na2SO4 and concentrated in vacuo. The crude products were purified by a silica-gel column chromatography with petroleum ether and EtOAc as eluent to give the desired benzoquinones 2, 7, 6.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Wang, Jin; Li, Shuo; Yang, Tao; Yang, Jian; European Journal of Medicinal Chemistry; vol. 86; (2014); p. 710 – 713;,
Ether – Wikipedia,
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