Category: 106854-77-7

Reference of 106854-77-7, The chemical industry reduces the impact on the environment during synthesis 106854-77-7, name is 1-Bromo-4-(2,2,2-trifluoroethoxy)benzene, I believe this compound will play a more active role in future production and life.

Step 7: 1 -Benzyl-N,4-dimethyl-N-neopentyl-3-(4-(2,2,2-trifluoroethoxy)phenyl)-5- (trifluoromethyl)-1 H-pyrrole-2-carboxamide (SC-260)Under an nitrogen atmosphere 1 -benzyl-N,4-dimethyl-N-neopentyl-3-(4,4,5,5-tetramethyl-1 3,2- dioxaborolan-2-yl)-5-(trifluoromethyl)-1 H-pyrrole-2-carboxamide (106 mg, 0.216 mmol) was dissolved in DMF (1 mL) and L1OH (4 mg, 0.216 mmol), bis(tri-tert-butylphosphine)palladium (0) (6 mg, 0.014 mmol) and 1-bromo-4-(2,2,2-trifluoroethoxy)benzene (50 mg, 0.196 mmol) were subsequently added. The reaction mixture was stirred at 80C under microwave irridation for I h. The mixture was cooled to RT and the reaction was stopped by addition of 1 M NaOH solution (2 mL). The crude product was extracted with EtOAc (2×3 mL) and the combined organic layers were washed with water (3×1 mL), dried over Na2SO4, filtered and the solvent was removed under reduced pressure. The crude mass was purified by flash chromatography to give SC-260 (95 mg, 89.7 %).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Bromo-4-(2,2,2-trifluoroethoxy)benzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; GRUeNENTHAL GMBH; SCHUNK, Stefan; REICH, Melanie; STEINHAGEN, Henning; DAMANN, Nils; SKONE, Philip; HAMLYN, Richard; KIRBY, Robert; ROGERS, Marc; SUTTON, Kathy; WO2014/32801; (2014); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthetic Route of 106854-77-7, A common heterocyclic compound, 106854-77-7, name is 1-Bromo-4-(2,2,2-trifluoroethoxy)benzene, molecular formula is C8H6BrF3O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 7: 1-Benzyl-N,4-dimethyl-N-neopentyl-3-(4-(2,2,2-trifluoroethoxy)phenyl)-5-(trifluoromethyl)-1H-pyrrole-2-carboxamide (SC-260) Under an nitrogen atmosphere 1-benzyl-N,4-dimethyl-N-neopentyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5-(trifluoromethyl)-1H-pyrrole-2-carboxamide (106 mg, 0.216 mmol) was dissolved in DMF (1 mL) and LiOH (4 mg, 0.216 mmol), bis(tri-tert-butylphosphine)palladium (0) (6 mg, 0.014 mmol) and 1-bromo-4-(2,2,2-trifluoroethoxy)benzene (50 mg, 0.196 mmol) were subsequently added. The reaction mixture was stirred at 80 C. under microwave irridation for 1 h. The mixture was cooled to RT and the reaction was stopped by addition of 1M NaOH solution (2 mL). The crude product was extracted with EtOAc (2*3 mL) and the combined organic layers were washed with water (3*1 mL), dried over Na2SO4, filtered and the solvent was removed under reduced pressure. The crude mass was purified by flash chromatography to give SC-260 (95 mg, 89.7%).

The synthetic route of 106854-77-7 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 106854-77-7, name is 1-Bromo-4-(2,2,2-trifluoroethoxy)benzene, A new synthetic method of this compound is introduced below., category: ethers-buliding-blocks

1-BROMO-4- (2, 2,2-trifluoroethoxy) benzene (1) (0.85 g, MW 255.03, 1.5 eq), pinacol diborane (from Aldrich, 0.89 g, MW 253.95, 1.6 eq), potassium acetate (from Aldrich, 0.86 g, MW 98.15, 4.0 eq), and (1, 1′-BIS (diphenylphosphino)- ferrocene) dichloropalladium (II) complex with dichloromethane (from Aldrich, 54 mg, MW 816.64, 0.03 eq) were charged in a round-bottom flask. The flask was purged with N2. N, N-DIMETHYLFORMAMIDE (from Aldrich, 8.0 ml) was then added, and the mixture was stirred at 80C for 2 hr. Tert-butyl 4-[(6-BROMOPYRIDIN-3-YL) SULFONYL] tetrahydro-2H-pyran- 4-carboxylate (2) (0.90 g, MW 406.29) was then added, along with sodium carbonate solution (2 M aqueous, 5.5 ml, 5 eq) and additional palladium complex (above, 54 mg, 0.03 eq). The reaction was continued at 80C for 3 hr. Afterward, the mixture was cooled to room temperature and filtered through a Celite pad. The filter cake was washed with ethyl acetate (2 x 50 ml). The filtrate and washes were then combined and washed with water (3 x 100 ml) and brine (1 x 100ML). The organics were then dried over sodium sulfate and concentrated to form a black residue. The residue was chromatographed (silica gel, ethyl acetate: hexanes, 1: 5) to afford TERT-BUTYL-4- (F 6- [4- (2, 2,2- TRIFLUOROETHOXY) phenyl] pyridin-3-yl} sulfonyl) tetrahydro-2H-pyran-4-carboxylate (3) as a white solid (0.26 g, 24 % yield). The product (3) was confirmed by LCMS. The “equivalents”above indicate equivalents relative to the charged amount OF TERT-BUTYL 4- [ (6- bromopyridin-3-yl) sulfonyl] TETRAHYDRO-2H-PYRAN-4-CARBOXYLATE.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; PHARMACIA CORPORATION; WO2004/48368; (2004); A2;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Application of 106854-77-7, These common heterocyclic compound, 106854-77-7, name is 1-Bromo-4-(2,2,2-trifluoroethoxy)benzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

1-BROMO-4- (2, 2, 2-trifluoroethoxy) benzene (14.5 g, 57 mmol) was dissolved in toluene (250ML) under an argon atmosphere. tert-Butyl PIPERAZINE-1-CARBOXYLATE (12.7 g, 68 mmol), sodium tert-butoxide (7.6 g, 79.5 mmol) rac-2,2′-bis (DIPHENYLPHOSPHINO)-1, 1 -BINAPHTHYL (200 mg, 0.32 mmol) and tris (dibenzylideneacetone) dipalladium (0) (200 mg, 0.2 mmol) were added and the reaction heated to 80 C for 4 hours. The mixture was then cooled and filtered through Celite to yield crude tert-butyl 4- [4- (2, 2,2-trifluoroethoxy) phenyl] piperazine-1- carboxylate (32.47 g). H NMR (400 MHZ, CDC13) : 8 6.90 (4 H, s), 4.30 (2 H, q), 3.60 (4 H, m), 3.05 (4 H, m), 1.45 (9 H, s); 7TL/Z (ES) 305 (MHS- BU).

Statistics shows that 1-Bromo-4-(2,2,2-trifluoroethoxy)benzene is playing an increasingly important role. we look forward to future research findings about 106854-77-7.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2005/822; (2005); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthetic Route of 106854-77-7, The chemical industry reduces the impact on the environment during synthesis 106854-77-7, name is 1-Bromo-4-(2,2,2-trifluoroethoxy)benzene, I believe this compound will play a more active role in future production and life.

Step 7: 1 -Benzyl-N,4-dimethyl-N-neopentyl-3-(4-(2,2,2-trifluoroethoxy)phenyl)-5- (trifluoromethyl)-1 H-pyrrole-2-carboxamide (SC-260)Under an nitrogen atmosphere 1 -benzyl-N,4-dimethyl-N-neopentyl-3-(4,4,5,5-tetramethyl-1 3,2- dioxaborolan-2-yl)-5-(trifluoromethyl)-1 H-pyrrole-2-carboxamide (106 mg, 0.216 mmol) was dissolved in DMF (1 mL) and L1OH (4 mg, 0.216 mmol), bis(tri-tert-butylphosphine)palladium (0) (6 mg, 0.014 mmol) and 1-bromo-4-(2,2,2-trifluoroethoxy)benzene (50 mg, 0.196 mmol) were subsequently added. The reaction mixture was stirred at 80C under microwave irridation for I h. The mixture was cooled to RT and the reaction was stopped by addition of 1 M NaOH solution (2 mL). The crude product was extracted with EtOAc (2×3 mL) and the combined organic layers were washed with water (3×1 mL), dried over Na2SO4, filtered and the solvent was removed under reduced pressure. The crude mass was purified by flash chromatography to give SC-260 (95 mg, 89.7 %).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Bromo-4-(2,2,2-trifluoroethoxy)benzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; GRUeNENTHAL GMBH; SCHUNK, Stefan; REICH, Melanie; STEINHAGEN, Henning; DAMANN, Nils; SKONE, Philip; HAMLYN, Richard; KIRBY, Robert; ROGERS, Marc; SUTTON, Kathy; WO2014/32801; (2014); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Adding a certain compound to certain chemical reactions, such as: 106854-77-7, name is 1-Bromo-4-(2,2,2-trifluoroethoxy)benzene, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 106854-77-7, Computed Properties of C8H6BrF3O

EXAMPLE 7 4-(2,2,2-Trifluoroethoxy)phenylhydrazine hydrochloride A solution of 4-bromophenyl 2,2,2-trifluoroethyl ether (5.2 g, 20 mmol) in THF (75 ml) was cooled to -75 C. under nitrogen. A solution of 2.7M n-butyllithium (7.5 ml, 20 mmol) was added dropwise. After 15 minutes, a solution of di-t-butylazodicarboxylate (4.5 g, 19 mmol) in THF (30 ml) was added quickly with stirring. The solution was allowed to warm to -40 C., resulting in the formation of a precipitate. Acetic acid (1.5 ml), water (10 ml), saturated sodium chloride (10 ml) and hexane (100 ml) were then added to the mixture. The organic solution was dried over MgSO4, filtered and evaporated. The residue was dissolved in 1:1 carbon tetrachloride-hexane and left to crystallize overnight. The resulting crystalline precipitate was collected, providing 4.25 g of white powder.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Bromo-4-(2,2,2-trifluoroethoxy)benzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Ortho Pharmaceutical Corporation; US4864032; (1989); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem