Category: 4003-89-8

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4003-89-8, name is 7-Methoxy-1,2,3,4-tetrahydronaphthalen-2-amine belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 4003-89-8

(b) An amount of 3.01 g of 2-amino-7-methoxy-1,2,3,4-tetrahydronaphthalene is reacted under stirring at room temperature for 4 days with 2.04 g of styrene. After addition of ethyl acetate, to the reaction mixture there is added a saturated solution of hydrogen chloride in isopropyl alcohol to obtain the 2-[(7-methoxy-1,2,3,4-tetrahydronaphth-2-yl)amino]-1-phenylethanol hydrochloride. Yield: 31% of the theoretical value.

The synthetic route of 4003-89-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Sanofi; US4707497; (1987); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Related Products of 4003-89-8, A common heterocyclic compound, 4003-89-8, name is 7-Methoxy-1,2,3,4-tetrahydronaphthalen-2-amine, molecular formula is C11H15NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 17; Acetic acid 2-[3-(7-methoxy-1 ,2,3,4-tetrahydro-naphthalen-2-yl)-thioureido]-ethyl ester(compound 17); A solution of 7-methoxy-1 ,2,3,4-tetrahydro-naphthalen-2-ylamine (0.34 g) in toluene (10 mL) was treated with acetic acid 2-isothiocyanato-ethyl ester (0.28 g, cf. Collect. Czech. Chem Commun. 1986, 51 , 112-117), refluxed for 1 h and stirred at room temperature overnight. Purification by chromatography on silica gel yielded the product (0.45 g).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; BASF SE; WO2008/145615; (2008); A2;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Application of 4003-89-8, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 4003-89-8 as follows.

Example 16: Benzoic acid 2-[3-(7-methoxy-1 ,2,3,4-tetrahydro-naphthalen-2-yl)-thioureido]-ethyl ester (compound 16); A solution of 7-methoxy-1 ,2,3,4-tetrahydro-naphthalen-2-ylamine (0.34 g) in toluene (10 ml) was treated with benzoic acid 2-isothiocyanato-ethyl ester (0.39 g, cf. Collect. Czech. Chem Commun. 1986, 51, 112-117), refluxed for 1 h and stirred at room tem- perautre overnight. Purification by Chromatography on silica gel yielded the product (0.32 g), m.p. 103-106 0C.

According to the analysis of related databases, 4003-89-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BASF SE; WO2008/145615; (2008); A2;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 4003-89-8, name is 7-Methoxy-1,2,3,4-tetrahydronaphthalen-2-amine, A new synthetic method of this compound is introduced below., SDS of cas: 4003-89-8

(a) A solution of 1-[1-(p-toluenesulfonyl)indol-4-yloxy]-2,3-epoxypropane (3.9 g) and 2-amino-7-methoxytetralin (2.2 g) in isopropanol (40 ml) is refluxed for 3 hours. The reaction mixture is then evaporated to dryness, the residue is dissolved in ethyl acetate and the obtained solution is washed with water, dried over sodium sulfate and evaporated to dryness. The residue is taken up in ethyl acetate/isopropanol and the obtained solution is made acidic by the addition of HCl/isopropanol. The precipitate which forms is recovered by filtration, and suspended in hot ethanol. The suspension is then cooled and filtered and the solid recovered by filtration is dried yielding 3.1 g of N-(7-methoxy-1,2,3,4-tetrahydronaphth-2-yl)-2-hydroxy-3-[1-(p-toluenesulfonyl)indol-4-yloxy]propanamine hydrochloride; m.p. 228-231 C.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Elf Sanofi; US5254595; (1993); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem