Application of 4003-89-8, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 4003-89-8 as follows.
Example 16: Benzoic acid 2-[3-(7-methoxy-1 ,2,3,4-tetrahydro-naphthalen-2-yl)-thioureido]-ethyl ester (compound 16); A solution of 7-methoxy-1 ,2,3,4-tetrahydro-naphthalen-2-ylamine (0.34 g) in toluene (10 ml) was treated with benzoic acid 2-isothiocyanato-ethyl ester (0.39 g, cf. Collect. Czech. Chem Commun. 1986, 51, 112-117), refluxed for 1 h and stirred at room tem- perautre overnight. Purification by Chromatography on silica gel yielded the product (0.32 g), m.p. 103-106 0C.
According to the analysis of related databases, 4003-89-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; BASF SE; WO2008/145615; (2008); A2;,
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