Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 368-21-8, name is 1-(Benzyloxy)-2-fluorobenzene, A new synthetic method of this compound is introduced below., Safety of 1-(Benzyloxy)-2-fluorobenzene
O-fluorophenol (5.0 g, 44.6 mmol) was dissolved in tetrahydrofuran (20 mL) was slowly added to tetrahydrofuran (20 mL) suspended in 60% by weight of sodium hydride (2.3 g, 57.5 mmol). After stirring for 5 min, 0.2 mmol of tetrabutylammonium iodide (TBAI) was added and then benzyl bromide (7.3mL, 61.4mmol), a significant exotherm, plus the reaction 0.5h, TLC showed that the raw material has been reacted. The mixture was quenched with saturated aqueous ammonium chloride and extracted with ethyl acetate (2 × 30 mL). The organic phases were combined, dried over anhydrous magnesium sulfate and concentrated to give 11.9 g of the crude product (intermediate A-1a) as a colorless oily liquid. The crude product was dissolved in acetonitrile (50 mL), N-bromosuccinimide (7.3 g, 44.8 mmol) was added and the reaction was carried out at 70 C for 3 h. TLC showed that the starting material had been reacted and most of the acetonitrile was distilled off. 50 mL of water, stirred for 15 min and extracted with ethyl acetate (3 × 30 mL). The combined organic phases were dried over anhydrous magnesium sulfate and purified by column chromatography (pure petroleum ether (PE)) to afford the bromo product (Intermediate A- 2a) as a light yellow oily liquid which solidified to a pale yellow solid (10.5 g, 84% yield). Intermediate A-2a: Murho (singlet): 56-59 C; 6H (300MuEtazeta; CDC13) 7.36-7.7.31 (5H, m), 7.22 (1H, dd, J = 8.1Etazeta, 2.4Etazeta) 7.12 (1H, dt, J = 8.7Hz, 1.8Etazeta), 6.84 (1H, t, J = 8.7Hz), 5.09 (2H, s)
The synthetic route of 368-21-8 has been constantly updated, and we look forward to future research findings.