Related Products of 607-58-9, These common heterocyclic compound, 607-58-9, name is 1-(Benzyloxy)naphthalene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Palladium acetate (3.4 mg, 0.015 mmol, 5 mol%) and sodium hydride (60% in oil, 18 mg, 0.45 mmol, 1.5 equiv) were suspended in DMA (1.0 mL) under nitrogen.After stirring at 25 C for 5 minutes, a solution of Compound 1 (0.3 mmol) in DMA (0.5 mL) was added, followed by a reaction at 50 C for 5 hours.The reaction was stopped by adding ice water, the pH was adjusted to 3.5 with dilute hydrochloric acid, and extracted with ethyl acetate.Drying with sodium sulfate, rotary evaporation and purification by column chromatography gave product 2, yield 98%.
The synthetic route of 607-58-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Soochow University (Suzhou); Zhang Shilei; Liu Ye; Mao Yujian; Gui Jingjing; Sun Wanwan; Wang Liudi; (15 pag.)CN108358760; (2018); A;,
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