89282-70-2 Archives - Ethers-buliding-blocks

Sep-21 News Extended knowledge of 89282-70-2

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 89282-70-2.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 89282-70-2, name is 2-Methoxy-2-methylpropan-1-amine, This compound has unique chemical properties. The synthetic route is as follows., name: 2-Methoxy-2-methylpropan-1-amine

A mixture of phenyl 5-({trans-4-[(2-chloro-4-fluoro-5-methylphenyl)carbamoyl]cyclohexyl}carbamoyl)- 1 H-im idazole-4-carboxylate (100 mg, 0.200 mmol) and 2-methoxy-2-methylpropan-1 -amine (103 mg, 1 .00 mmol, GAS No 89282-70-2) in tetrahydrofuran (5.0 ml) was stirred at 60CC over nigh t. For work-up, the reaction mixture wasconcentrated and the residue was purified by preparative HPLG (Method 9) to yield the title compound (48.0 mg, 48% yield).LG-MS (Method 3): R = 1 .16 mm; MS (ESIpos) m/z = 508.3 [M+H].1HNMR (400 MHz, DMSO-d6): 6[ppm] = 13.37-13.15 (m, 1H), 11.22-1 0.96 (m, 1H), 9.46 (br.s., 1 H), 8.47-7.96 (m, 1 H), 7.83 (5, 1 H), 7.50 (d, 1 H), 7.41 (d, 1 H), 3.90-3.56 (m, 1 H), 3.37 (d,2H), 3.15 (br. s., 3H), 2.21 (d, 3H), 2.14-1.79 (m, 4H), 1.64-1.47 (m, 3H), 1.40-1.21 (m, 1H),1.14 (5, 6H).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 89282-70-2.

Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; EIS, Knut; ACKERMANN, Jens; WAGNER, Sarah; BUCHGRABER, Philipp; SUeLZLE, Detlev; HOLTON, Simon; BENDER, Eckhard; LI, Volkhart; LIU, Ningshu; SIEGEL, Franziska; LIENAU, Philip; BAIRLEIN, Michaela; VON NUSSBAUM, Franz; HERBERT,Simon; KOPPITZ, Marcus; (734 pag.)WO2016/177658; (2016); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Some tips on 2-Methoxy-2-methylpropan-1-amine

According to the analysis of related databases, 89282-70-2, the application of this compound in the production field has become more and more popular.

A mixture of phenyl 5-({trans-4-[(2-chloro-4,5-difluorophenyl)carbamoyl]cyclohexyl}carbamoyl)-1 H-im idazole-4-carboxylate (100 mg, 0.199 mmol,) and 2-methoxy-2-methylpropan-1 -amine (103 mg, 0.994 mmol, GAS No 89282-70-2) in tetrahydrofuran (5.0 ml) was stirred at 600 ove r night. For work-up, the reaction mixture was concentrated and the residue was first purified by flash chromatography (10 g Snap Gartridge, ethyl acetate/ethanol gradient, 0% -> 5% ethanol) followd by purification withpreparative HPLG (Method 9) to yield the title compound (46.0 mg, 45% yield).LG-MS (Method 3): R = 1.15 mm; MS (ESIpos) m/z = 512.2 [M+H].1HNMR (400 MHz, DMSO-d6): 6 [ppm] = 13.38-13.09 (m, 1H), 11.25-1 0.90 (m, 1H), 9.67-9.53 (m, 1H), 8.52-8.25 (m, 0.5H), 8.21-7.95 (m, 0.5H), 7.87-7.75 (m, 3H), 3.92-3.59 (m, 1H),3.37 (d, 2H), 3.15 (5, 3H), 2.15-1.77 (m, 4H), 1.65-1.20 (m, 4H), 1.14 (5, 6H).

According to the analysis of related databases, 89282-70-2, the application of this compound in the production field has become more and more popular.

Sources of common compounds: 89282-70-2

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Synthetic Route of 89282-70-2, A common heterocyclic compound, 89282-70-2, name is 2-Methoxy-2-methylpropan-1-amine, molecular formula is C5H13NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

[0407] In Examples, a room temperature usually indicates10 to 30 C. ?H NMR indicates a proton nuclear magnetic resonance spectrum, and chemical shift (6) is expressed in ppm, using tetramethylsilane as an internal standard substance.; [0424] The intermediate compound (1) (0.24 g, 1.0 mmol), 2-methoxy-2-methylpropylamine (0.13 g, 1.2 mmol), and HOST (0.01 g, 0.1 mmol) were added to chloroform (Amylene-added product) (2.5 mE). Afier EDCD (0.24 g, 1.2 mmol) was added to the mixed liquid at room temperature, the mixture was stirred at room temperature for 3 hours. Thereafier, dilute hydrochloric acid was added to the reaction mixture, followed by extraction with chloroform two times. After the organic layer was passed through a short column to remove impurities, this was concentrated under reduced pressure. The residue was subjected to silica gel column chromatography to obtain 0.24 g of a compound offollowing formula: (hereinafier, referred to as compound (8)).; [0425] ?H-NMR (CDC13, TMS, oe(ppm)): 1.21 (6H, s),3.23 (3H, s), 3.46 (2H, d), 4.61 (2H, s), 4.65 (2H, s), 6.73(1H, s), 7.10 (1H, br s), 7.30-7.40 (5H, m)

Reference:
Patent; SUMITOMO CHEMICAL COMPANY, LIMITED; MITSUDERA, Hiromasa; OKAJIMA, Mayumi; KOWATA, Ayano; AWASAGUCHI, Kenichiro; UJIHARA, Kazuya; (108 pag.)US2017/295789; (2017); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Sources of common compounds: C5H13NO

The chemical industry reduces the impact on the environment during synthesis 2-Methoxy-2-methylpropan-1-amine. I believe this compound will play a more active role in future production and life.

Synthetic Route of 89282-70-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 89282-70-2, name is 2-Methoxy-2-methylpropan-1-amine, This compound has unique chemical properties. The synthetic route is as follows.

In a round bottom flask under nitrogen 100 mg (0.23 mmol) of intermediate Awas dissolved in 4 mL ofCH2Ch and 0.12g ofDIPEA (0.92 mmol) was added followed by 108mg (0.7 mmol) of 2-Methoxy-2-methyl-propylamine. The mixture was allowed to stir overnight and then condensed in vacuo. The residue was dissolved in 20 mL ofEtOAc andwashed with 2x 20 mL of water, 20 mL of brine, dried over Na2S04 and condensed in vacuo.Purification by biotage flash chromatography (Si02, MeOH/CH2Ch/Et3N gradient) affords 71mg of the title compound as a clear viscous oil

The chemical industry reduces the impact on the environment during synthesis 2-Methoxy-2-methylpropan-1-amine. I believe this compound will play a more active role in future production and life.

Reference:
Patent; ZAFGEN, INC.; ZAHLER, Robert; VATH, James, F.; WO2013/169860; (2013); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Introduction of a new synthetic route about 89282-70-2

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Methoxy-2-methylpropan-1-amine, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 89282-70-2, name is 2-Methoxy-2-methylpropan-1-amine, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 89282-70-2, Recommanded Product: 89282-70-2

A mixture of phenyl 5-({trans-4-[(2-chloro-4-fluorophenyl)carbamoyl]cyclohexyl}carbamoyl)-1 H-imidazole-4-carboxylate (150 mg, 0.309 mmol,) and 2-methoxy-2-methylpropan-1 -amine(160 mg, 1.55 mmol, GAS No 89282-70-2) in tetrahydrofuran (4.8 ml) was stirred at 600over night. For work-up, the reaction mixture was concentrated and the residue was purified by flash chromatography (25 g Snap Cartridge, ethyl acetate/ethanol gradient, 0% -> 5% ethanol) to yield the title compound (18.0 mg, 12 yield).[C-MS (Method 6): R = 1 .08 mm; MS (ESIpos) m/z = 494.2 [M+H].1HNMR (400 MHz, DMSO-d6): 6 [ppm] = 13.20-12.45 (m, 1H), 11.43-1 0.70 (m, 1H), 9.52 (s,1H), 8.69-7.89 (m, 1H), 7.82 (s, 1H), 7.65-7.57 (m, 1H), 7.53-7.47 (m, 1H), 7.27-7.18 (m,1H), 3.89-3.66 (m, 1H), 3.37 (d, 2H), 3.15 (s, 3H), 2.48-2.38 (m, 1H), 2.10-1.75 (m, 4H),1.71 -1 .32 (m, 4H), 1.14 (s, 6H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Methoxy-2-methylpropan-1-amine, and friends who are interested can also refer to it.

The origin of a common compound about C5H13NO

The synthetic route of 2-Methoxy-2-methylpropan-1-amine has been constantly updated, and we look forward to future research findings.

These common heterocyclic compound, 89282-70-2, name is 2-Methoxy-2-methylpropan-1-amine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. HPLC of Formula: C5H13NO

The following Examples were prepared according to Method 5 (Example 54) above using 8-chloro-A/-(2-methoxy-4-(1 -methyl-1 H-pyrazol-4-yl)phenyl)pyrido[3,4- d]pyrimidin-2-amine (Example 94) and the appropriate amine as described. Where the amine hydrochloride was used, triethylamine (190uL, 0.373 mmol) was also added to the reaction. The crude reaction residues were purified as above or according to one of the following methods: Method A: Silica gel column chromatography eluting with 0-5% or 0-10% MeOH in DCM. Method B: Silica gel column chromatography eluting with 0-5% MeOH in EtOAc. Method C: Silica gel column chromatography eluting with 0-70% EtOAc in cyclohexane followed by reverse phase preparative HPLC eluting with 10-90% MeOH in water (0.1% formic acid).

The synthetic route of 2-Methoxy-2-methylpropan-1-amine has been constantly updated, and we look forward to future research findings.

Reference:
Patent; CANCER RESEARCH TECHNOLOGY LIMITED; HOELDER, Swen; BLAGG, Julian; SOLANKI, Savade; WOODWARD, Hannah; NAUD, Sebastian; BAVETSIAS, Vassilios; SHELDRAKE, Peter; INNOCENTI, Paolo; CHEUNG, Jack; ATRASH, Butrus; WO2014/37750; (2014); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Extended knowledge of 89282-70-2

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 89282-70-2.

Some tips on 2-Methoxy-2-methylpropan-1-amine

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Methoxy-2-methylpropan-1-amine, other downstream synthetic routes, hurry up and to see.

Related Products of 89282-70-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 89282-70-2, name is 2-Methoxy-2-methylpropan-1-amine belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Preparation 3 Synthesis of N-(2-methoxy-2-methylpropyl) formamide Formic acid (19.2 g, 0.40 mol) and acetic anhydride (40.8 g, 0.40 mol) Were combined and heated to 45-50 C. for one hour and cooled to approximately 0 C. in an ice/acetone bath. A solution of 2-methoxy-2-methylpropyl-1-amine (36 g, 0.35 mol), precooled to approximately 0 C. in an ice/acetone bath was added slowly while keeping the temperature of the mixture below 12 C. After the addition was complete, the mixture was allowed to warm slowly to room temperature and was stirred at room temperature overnight. The solution was evaporated and the residue distilled at 97-107 C./1-2 mm Hg. to give 43.2 g (94%). NMR (CDCl3): delta 1.2 (s, 6H, CH3), 3.3 (m, 5H, CH3 O and CH2), 6.6 (b, 1H, NH), 8.2 (bs, 1H, HCO).

Reference:
Patent; E. I. Du Pont de Nemours and Company; US4988827; (1991); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

New learning discoveries about 2-Methoxy-2-methylpropan-1-amine

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 89282-70-2, name is 2-Methoxy-2-methylpropan-1-amine, A new synthetic method of this compound is introduced below., Safety of 2-Methoxy-2-methylpropan-1-amine

A mixture of phenyl 5-[(trans-4-{[2-chloro-5-(morpholin-4-yl)phenyl]carbamoyl}cyclohexyl)carbamoyl]-1 H-imidazole-4-carboxylate (100 mg, 0.181 mmol,) and 2-methoxy-2-methylpropan-1 -amine (93 mg, 0.906 mmol, GAS No 89282-70-2) in tetrahydrofuran (4.6 ml) was stirred at 60CC ove r night. For work-up the reaction mixturewas concentrated and purified by preparative HPLG (Method 9) to yield the title compound (5.2 mg, 5% yield).LG-MS (Method 6): R = 1 .08 mm; MS (ESIpos) m/z = 561 .3 [M÷H]. 1HNMR (400 MHz, DMSO-d6): 6 [ppm] = 10.07-9.57 (m, 1H), 9.51-9.04 (m, 2H), 7.35-7.11(m, 3H), 6.81 -6.76 (m, 1H), 3.82-3.61 (m, 5H), 3.15 (s, 3H), 3.13-3.03 (m, 4H), 2.02-1.86 (m,4H), 1.62-1.43 (m, 2H), 1.42-1.27 (m, 2H), 1.13 (s, 6H).

Share a compound : 2-Methoxy-2-methylpropan-1-amine

According to the analysis of related databases, 89282-70-2, the application of this compound in the production field has become more and more popular.

Reference of 89282-70-2, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 89282-70-2 as follows.

To a solution of (2R)-4-(6-(2-fluoro-4-formylphenyl)-1 -oxoisoquinolin-2(1 H)-yl)-2-methyl-2- (methylsulfonyl)-N-((tetrahydro-2H-pyran-2-yl)oxy)butanamide (2.2 g, 4.04 mmol) in 1 ,2- dichloroethane (30 mL) at 0 C was added 2-methoxy-2-methylpropan-1 -amine (1 .250 g, 12.12 mmol). The reaction mixture was stirred at room temperature overnight and sodium triacetoxyhydroborate (2.57 g, 12.12 mmol) was added at 0 C. The reaction was allowed to warm to room temperature and was sirred for 1 hr. The reaction was diluted with DCM (20 ml_) and water (20 ml_) and the aqueous phase was extracted with DCM (20 ml x 3). The combined organic layers were washed with brine (30 ml_), dried over sodium sulphate and concentrated. The residue was purified by silical gel chromatography (MeOH/DCM: 0-20%) to afford (2R)-4-(6-(2-fluoro-4-(((2-methoxy-2- methylpropyl)amino)methyl)phenyl)-1 -oxoisoquinolin-2(1 H)-yl)-2-methyl-2- (methylsulfonyl)-N-((tetrahydro-2H-pyran-2-yl)oxy)butanamide (2.32 g, 3.67 mmol, 91 % yield) as a colorless oil. LCMS: [M+H] 632.4.

According to the analysis of related databases, 89282-70-2, the application of this compound in the production field has become more and more popular.