Category: 89282-70-2

Adding a certain compound to certain chemical reactions, such as: 89282-70-2, name is 2-Methoxy-2-methylpropan-1-amine, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 89282-70-2, SDS of cas: 89282-70-2

A solution of 2- { [5-bromo- 1 -(2-chlorophenyl)- 1 H-i ,2,4-triazol-3 -yl]methyl} -5-(4-chlorophenyl)-4- [(2S)-3 ,3,3 -trifluoro-2-hydroxypropyl] -2,4-dihydro-3H- 1 ,2,4-triazol-3 -one (Example 5A, 100mg, 173 jimol) in acetonitrile (330 jil) was treated with N,N-diisopropylethylamine (450 jil, 2.6mmol) and 2-methoxy-2-methylpropan-1-amine (178 mg, 1.73 mmol). The resulting mixture washeated for 5 h at 180C under microwave irradiation and evaporated. The residue was purified by preparative HPLC (Method 5) affording 82.5 mg (79% of th.) of the title compound.LC-MS (Method 2): R = 1.05 mm; MS (ESIpos): mlz = 600.2 [M+H]1H-NMR (400 MHz, DMSO-d6) [ppm]: 7.44 – 7.81 (m, 8H), 6.87 (d, 1H), 6.12 (t, 1H), 4.77 -4.93 (m, 2H), 4.29 (br ddd, 1H), 3.78 – 4.08 (m, 2H), 3.30 – 3.19 (m, 2H, overlapping with HDO peak), 3.06 (s, 3H), 1.05 (s, 6H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Methoxy-2-methylpropan-1-amine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; COLLIN-KROePELIN, Marie-Pierre; KOLKHOF, Peter; NEUBAUER, Thomas; FUeRSTNER, Chantal; POOK, Elisabeth; TINEL, Hanna; SCHMECK, Carsten; WASNAIRE, Pierre; SCHIRMER, Heiko; LUSTIG, Klemens; (205 pag.)WO2019/81299; (2019); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 89282-70-2, name is 2-Methoxy-2-methylpropan-1-amine, A new synthetic method of this compound is introduced below., SDS of cas: 89282-70-2

Hydrochloric acid generated from concentrated sulfuric acid and sodium chloride (or from dripping of concentrated hydrochloric acid over concentrated sulfuric acid), was bubbled through a solution of MIBA (298.73 g, 97.0% (GC), 2.81 mmol) in hexanes (7160 mL) until most of the forming MIBAHCl solubilizes. The solvent was carefully removed by rotary evaporation under reduced pressure. The obtained product, a white solid, was dried under high vacuum and triturated in hot hexanes (2860 mL). MIBAHCl was filtered off under a blanket of argon and yielded as a white solid (386.88 g, 99.0% (GC), 98% yield). The title compound is highly hygroscopic and should be stored in a dessicator. m.p.: 121-123 C.; TLC Rf 0.5 (90:9.75:0.25 CH2Cl2/CH3OH/NH4OH, sample diluted in a mixture of 1 mL:1 drop CH3OH/28% NH4OH, detection with ninhydrine spray); FTIR(KBr): 3426, 2978, 2692, 2596, 2008, 1618, 1499, 1476, 1396, 1374, 1329, 1264, 1206, 1177, 1096, 1057, 1013, 949, 871, 841, 720 cm-1; 1H (600 MHz, CDCl3): delta 1.20 (s, 6H, 2 CH3), 2.91 (q, 2H, J=5.9 Hz, CH2), 3.14 (s, 3H, OCH3), 8.21 (br s, 3H, NH3+); 13C-NMR (151 MHz, CDCl3): delta 22.5 (2 CH3), 47.9 (CH2), 49.5 (OCH3), 72.0 (C).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; DRAXIS Specialty Pharmaceuticals Inc.; US2008/102028; (2008); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Application of 89282-70-2,Some common heterocyclic compound, 89282-70-2, name is 2-Methoxy-2-methylpropan-1-amine, molecular formula is C5H13NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 5 N-(3-{[(2-methoxy-2-methylpropyl)amino]methyl}-8-methylquinolin-7-yl)-4-(tetrahydrofuran-2-ylmethoxy)benzamide monohydrochloride [Show Image] N-(3-Formyl-8-methylquinolin-7-yl)-4-(tetrahydrofuran-2-ylmethoxy)benzamide (1.0 g) obtained in Reference Example 2 and 2-methoxy-2-methylpropan-1-amine 0.5 oxalate (600 mg) were suspended in 1-methyl-2-pyrrolidone (10 mL) and acetic acid (5.0 mL) and the mixture was stirred at room temperature for 3 hr. Sodium triacetoxyborohydride (2.35 g) was added and the mixture was stirred at room temperature for 3 hr. 1N Aqueous sodium hydroxide solution was added to quench the reaction and basify the mixture. The mixture was partitioned and extracted with ethyl acetate, the organic layer was added to a solution of citric acid (4.0 g) in water (40 mL)-dimethyl sulfoxide (20 mL), and the mixture was washed with ethyl acetate. 1N Aqueous sodium hydroxide solution was added to the aqueous layer, and the mixture was partitioned and extracted with ethyl acetate. The organic layer was washed with saturated brine and dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure. The obtained amorphous product was dissolved in ethyl acetate, and 4N hydrogen chloride-ethyl acetate solution (0.15 mL) was added. The obtained solid was recrystallized from ethyl acetate-methanol to give the title compound (101 mg, yield 8%) as a colorless solid. 1H NMR (300 MHz, DMSO-d6) delta: 1.20 (6 H, s), 1.68 – 1.72 (1 H, m), 1.87 – 1.90 (2 H, m), 1.96 – 2.00 (2 H, m), 2.68 (3 H, s), 2.97 – 3.00 (1 H, m), 3.11 (3 H, s), 3.68 – 3.81 (2 H, m), 4.02 – 4.06 (2 H, m), 4.16 – 4.20 (1 H, m), 4.42 (2 H, s), 7.09 (2 H, d, J=8.7 Hz), 7.75 (1 H, d, J=8.7 Hz), 7.90 (1 H, d, J=8.7 Hz), 8.04 (2 H, d, J=8.7 Hz), 8.72 (1 H, s), 9.20 (1 H, s), 9.27 (2 H, br), 10.25 (1 H, s).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Methoxy-2-methylpropan-1-amine, its application will become more common.

Reference:
Patent; Takeda Pharmaceutical Company Limited; EP2392573; (2011); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem