Synthetic Route of 89282-70-2, A common heterocyclic compound, 89282-70-2, name is 2-Methoxy-2-methylpropan-1-amine, molecular formula is C5H13NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
[0407] In Examples, a room temperature usually indicates10 to 30 C. ?H NMR indicates a proton nuclear magnetic resonance spectrum, and chemical shift (6) is expressed in ppm, using tetramethylsilane as an internal standard substance.; [0424] The intermediate compound (1) (0.24 g, 1.0 mmol), 2-methoxy-2-methylpropylamine (0.13 g, 1.2 mmol), and HOST (0.01 g, 0.1 mmol) were added to chloroform (Amylene-added product) (2.5 mE). Afier EDCD (0.24 g, 1.2 mmol) was added to the mixed liquid at room temperature, the mixture was stirred at room temperature for 3 hours. Thereafier, dilute hydrochloric acid was added to the reaction mixture, followed by extraction with chloroform two times. After the organic layer was passed through a short column to remove impurities, this was concentrated under reduced pressure. The residue was subjected to silica gel column chromatography to obtain 0.24 g of a compound offollowing formula: (hereinafier, referred to as compound (8)).; [0425] ?H-NMR (CDC13, TMS, oe(ppm)): 1.21 (6H, s),3.23 (3H, s), 3.46 (2H, d), 4.61 (2H, s), 4.65 (2H, s), 6.73(1H, s), 7.10 (1H, br s), 7.30-7.40 (5H, m)
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; SUMITOMO CHEMICAL COMPANY, LIMITED; MITSUDERA, Hiromasa; OKAJIMA, Mayumi; KOWATA, Ayano; AWASAGUCHI, Kenichiro; UJIHARA, Kazuya; (108 pag.)US2017/295789; (2017); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem