Extracurricular laboratory: Synthetic route of 1-Bromo-2-(difluoromethoxy)-4-fluorobenzene

The synthetic route of 954235-83-7 has been constantly updated, and we look forward to future research findings.

954235-83-7, name is 1-Bromo-2-(difluoromethoxy)-4-fluorobenzene, belongs to ethers-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 954235-83-7

A mixture of l-bromo-2-(difluoromethoxy)-4-fIuorobenzene (intermediate 176a, 70 mg), N-[3- chloro-4-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)phenyl]-2-[4-(ethylsulfonyl)phenyl]acetamide (intermediate 6b, 148 mg), PdCl2(dppi)-CH2CI2 adduct (18.98 mg) and Cs2C03 (114 mg) in acetonitrile (1.5 mL)/water (0.5 mL) was sealed in a vessel and heated in (lie microwave at 100C for 45 mins. The reaction mixture was filtered through celite and silica gel. The filtrate was concentrated under reduced pressure and the residue was purified by MDAP to afford N-(2-chloro-2′- (difluoromethoxy)-4′-fluoro-[l, -biphenyl]-4-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide (22 mg) as a white solid. ?-NMR (400 MHz, DMSO-<¾ delta ppm 1.10 (t, /= 7.2 Hz, 3H), 3.28 (q, J= 7.2 Hz, 2H), 3.84 (s; 2H), 7.21 (t, J= 73.2 Hz, 1H), 7.21 (m, 2H)} 7.28 (d, J - 8.4 Hz, 1H), 7.37 (m, 1H), 7.53 (dd, J= 2.0 Hz, 8.4 Hz, 1H), 7.62 (d, J= 8.0 Hz, 2H), 7.86 (d, J= 8.4 Hz, 2H), 7.91 (d, J= 2.0 Hz, 1H), 10.55 (s, 1H); 19F-NMR (376 MHz, DMSO-rf6) delta ppm -82.43, -110.64; MSiES4) m/? 498 (MH+). The synthetic route of 954235-83-7 has been constantly updated, and we look forward to future research findings. Reference:
Patent; GLAXO GROUP LIMITED; WANG, Yonghui; CAI, Wei; LIU, Qian; MENG, Qinghua; CHENG, Yaobang; YANG, Ting; ZHANG, Guifeng; XIANG, Jianing; WU, Chengde; WO2013/29338; (2013); A1;,
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The important role of 954235-83-7

The synthetic route of 954235-83-7 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 954235-83-7, name is 1-Bromo-2-(difluoromethoxy)-4-fluorobenzene, A new synthetic method of this compound is introduced below., Recommanded Product: 1-Bromo-2-(difluoromethoxy)-4-fluorobenzene

A mixture of l -bromo-2-(difluoromethoxy)-4-fluorobenzene (intennediate 176a, 75 mg), (6-(2- (4-(ethylsulfonyl)phenyl)acetamido)-2-methylpyridin-3-yl)boronic acid (intermediate 178a, 310 mg), PdCl2(dppf)-CH2Cl2 adduct (20.33 mg) and Na2COj (39.6 mg) in acetonitrile (2.4 mL)/water (0.8 mL) was sealed in a vessel and heated in the microwave at 100C for 45 mins. The mixture was filtered through celite and silica gel. The filtrate was concentrated under reduced pressure and the residue was purified by MDAP to afford N-(5-(2-(difIuoromethoxy)-4-fluorophenyl)-6-methylpyridin-2-yl)-2-(4- (ethyIsulfonyl)phenyi)acetarnide, trifluoroacetic acid salt (16 mg) as a white solid. ?-NMR (400 MHz, DMSO-i¾) delta ppm 1.10 (t, J= 7.2 Hz, 3H), 2.21 (s, 3H), 3.27 (q, J= 7.2 Hz, 2H), 3.89 (s, 2H), 7.22 (t, J= 72 Hz, 1H), 7.24 (m, 2H), 7.40 (m, 1H), 7.53 (d, J= 8.4 Hz, 1H), 7.63 (d, 7= 8.4 Hz, 2H), 7.85 (d, 8.4 Hz, 2H), 7.94 (d, J= 8.4 Hz, 1H), 10.92 (s, 1H); 19F-NMR (376 MHz, DMSO-Patent; GLAXO GROUP LIMITED; WANG, Yonghui; CAI, Wei; LIU, Qian; MENG, Qinghua; CHENG, Yaobang; YANG, Ting; ZHANG, Guifeng; XIANG, Jianing; WU, Chengde; WO2013/29338; (2013); A1;,
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Brief introduction of 954235-83-7

According to the analysis of related databases, 954235-83-7, the application of this compound in the production field has become more and more popular.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 954235-83-7 as follows. HPLC of Formula: C7H4BrF3O

A mixture of l-bromo-2-(difluoromethoxy)-4-fluorobenzene (intermediate 176a, 150 mg), (4-(2- (4-(ethylsulfonyI)phenyl)acetamido)-2,6-difluorophenyl)boronic acid (intermediate 122a, 404 mg), tri-ierf-butylphosphine, tetrafluoroboric acid salt (217 mg), Pd2(dba)j (171 mg) and sodium carbonate solution (2 M, 1.245 mL) in 1,4-dioxane (4.5 mL) was sealed in a vessel and heated in the microwave at 100C for 45 mins. The reaction mixture was filtered through celite and silica gel. The filtrate was concentrated under reduced pressure and the residue was purified by MDAP to afford N-(2′- (difluoromethoxy) -2,4′,6-trifiuoro-[ 1 , 1 ‘-biphenyl] -4-yl) -2-(4-(ethylsulfonyl)phenyl) acetamide ( 133 mg) as a yellow solid. ?-NMR (400 MHz, DMSO-Patent; GLAXO GROUP LIMITED; WANG, Yonghui; CAI, Wei; LIU, Qian; MENG, Qinghua; CHENG, Yaobang; YANG, Ting; ZHANG, Guifeng; XIANG, Jianing; WU, Chengde; WO2013/29338; (2013); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem