S-21 News Brief introduction of 38336-04-8

According to the analysis of related databases, 38336-04-8, the application of this compound in the production field has become more and more popular.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 38336-04-8 as follows. Recommanded Product: 2-(Benzyloxy)-1-ethanamine

(1) Take 10g of bromonitrobenzene dissolved inIn 50 ml acetonitrile,6.5 g 2-benzyloxyethylamine was added to the above solution under ice bath.Then add 20 ml of triethylamine,Reaction at room temperature for 6 hours,A yellow clear solution is obtained,The reaction solution was concentrated under reduced pressure,Dissolved in 200 ml of dichloromethaneWash 50 ml of water three timesCombine the organic phase,Dry with anhydrous sodium sulfateAfter filtration, spin dry to obtain a crude product.After purifying crude product column chromatography, it will be 10.8Compound II,Yield 91.7%.

According to the analysis of related databases, 38336-04-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Tierxi (Nanjing) Pharmaceutical Research And Development Co., Ltd.; Li Yantao; Mao Yu; Zhang Chi; Liu Chun; Cui Xilin; (13 pag.)CN107586291; (2018); A;,
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23-Sep-2021 News Some scientific research about 38336-04-8

According to the analysis of related databases, 38336-04-8, the application of this compound in the production field has become more and more popular.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 38336-04-8 as follows. COA of Formula: C9H13NO

General procedure: Ethyl 2-(4-chloro-3-nitrophenyl)-2-methylpropanoate (3a)(16.15 g, 0.0594 mol), 4 (27.77 g, 0.149 mol), K2CO3 (28.69 g,0.208 mol), KI (0.99 g, 5.94 mmol), TBAB (1.91 g, 5.94 mmol) and150 mL DMSO were added into a round-bottomed flask. The mixturewas heated to 120 C for 24 h then cooling to room temperature.The reaction mixture was diluted with saturated NH4Claqueous solution (250 mL) and extracted with CH2Cl2 (450 mL).The combined organic layer was washed with brine (300 mL), driedover anhydrous sodium sulfate, filtered, and concentrated in vacuo.The residue was purified by silica gel column chromatography (PE:EtOAc = 4:1) to give compound 5a (15.82 g) as yellow oil in 69%yields.

According to the analysis of related databases, 38336-04-8, the application of this compound in the production field has become more and more popular.

Reference:
Article; Chen, Dongxing; Shi, Jinyu; Liu, Jing; Zhang, Xueying; Deng, Xiaoying; Yang, Yanyan; Cui, Shuang; Zhu, Qihua; Gong, Guoqing; Xu, Yungen; Bioorganic and Medicinal Chemistry; vol. 25; 2; (2017); p. 458 – 470;,
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9/6/2021 News New downstream synthetic route of 38336-04-8

The synthetic route of 2-(Benzyloxy)-1-ethanamine has been constantly updated, and we look forward to future research findings.

Electric Literature of 38336-04-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 38336-04-8, name is 2-(Benzyloxy)-1-ethanamine belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

To 6-(1-((tert-butoxycarbonyl)amino)-2-ethoxy-2-oxoethyl)-5-fluoronicotinic acid 0.95 g (2.78 mmol) in dichloromethane (13 mL) was added triethylamine 1.15 mL (8.33 mmol, 3 eq), N-(3- dimethylaminopropyl)-N¢-ethylcarbodiimide hydrochloride 0.59 g (3.05 mmol, 1.1 eq), 1- hydroxybenzotriazole hydrate 0.41 g (3.06 mmol, 1.1 eq), followed by 2-(benzyloxy)ethan-1-amine ) 0.5 mL (3.33 mmol, 1.2 eq) and the reaction was stirred at RT for 18 h. The mixture was diluted with dichloromethane, washed with water/brine, dried over sodium sulfate and concentrated. The product was purified by flash chromatography on silica gel (30% ethyl acetate/hexanes) to afford the title compound. ESI-MS m/z 476 (MH)+.

The synthetic route of 2-(Benzyloxy)-1-ethanamine has been constantly updated, and we look forward to future research findings.

Reference:
Patent; VENATORX PHARMACEUTICALS, INC.; BURNS, Christopher J.; DAIGLE, Denis; CHU, Guo-Hua; HAMRICK, Jodie; BOYD, Steven A.; ZULLI, Allison L.; MESAROS, Eugen F.; CONDON, Stephen M.; TROUT, Robert E. Lee; MYERS, Cullen L.; XU, Zhenrong; (327 pag.)WO2019/226931; (2019); A1;,
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9/3/2021 News The important role of 38336-04-8

The synthetic route of 38336-04-8 has been constantly updated, and we look forward to future research findings.

38336-04-8, name is 2-(Benzyloxy)-1-ethanamine, belongs to ethers-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. SDS of cas: 38336-04-8

(1) Take 5g of p-fluoronitrobenzene dissolved in 50ml of acetonitrile,5.72 g under ice bath2-benzyloxyethylamine (A) is added to the above solution,Then add 9.5 ml of triethylamine,Reaction at 50C for 8 hours,A yellow clear solution is obtained,The reaction solution was concentrated under reduced pressure,Dissolved in 200 ml of dichloromethaneWash 50 ml of water three timesThe organic phases are combined and dried over anhydrous sodium sulfate.After filtration, spin down to give a crude product.The crude product was purified by column chromatography to give intermediate II 4.5 g as a yellow oil.Yield 48.1%.

The synthetic route of 38336-04-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Tierxi (Nanjing) Pharmaceutical Research And Development Co., Ltd.; Li Yantao; Mao Yu; Zhang Chi; Liu Chun; Cui Xilin; (13 pag.)CN107586291; (2018); A;,
Ether – Wikipedia,
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1-Sep-21 News The important role of 38336-04-8

Statistics shows that 2-(Benzyloxy)-1-ethanamine is playing an increasingly important role. we look forward to future research findings about 38336-04-8.

Application of 38336-04-8, These common heterocyclic compound, 38336-04-8, name is 2-(Benzyloxy)-1-ethanamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Compound 12 was synthesized by the method described in Synth. Commun.,25, 907 (1995), and Compound 13 and Compound 2 were synthesized by the method described in J. Ned. Chem., 38, 1673 (1995). Succinic anhydride (150.1 mg, 1.5 mmol) was gradually added to a pyridine solution (2.0 ml) of each of Compounds 12, 13 and 2 (1.0 mmol) at room temperature, followed by stirring at 100C for 1.5 to 4 hours, respectively. The reaction solution was cooled to room temperature, and 2 mol/l hydrochloric acid was added thereto, followed by extraction with dichloromethane. The organic layer was washed with a saturated brine, dried over anhydrous magnesium sulfate and then filtered. The solvent was evaporated under reduced pressure, and the residue was purified by silica gel column chromatography (hexane:ethyl acetate = 1:3) to give each of Compounds 14 to 16, respectively (yield 92 to 100%). (Compound 14)1H-NMR (CDCl3, 400MHz) delta (ppm): 2.51 (2H, t, J=7.0Hz), 2.69 (2H, t, J=7.0Hz), 3.49 (2H, t, J=5.0Hz), 3.59 (2H, t, J=5.0Hz), 4.54 (2H, s), 6.20 (1H, t, J=5.0Hz), 7.31-7.42 (5H, m).13C-NMR (CDCl3, 75MHz) delta (ppm): 175.8 (C), 172.5 (C), 137.4 (C), 128.1 (CHx2), 127.5 (CH×2), 127.5 (CH), 72.6 (CH2), 68.2 (CH2), 39.1 (CH2), 30.2 (CH2), 29.2 (CH2). (Compound 15)1H-NMR (CDCl3, 400MHz) delta (ppm): 2.49 (2H, t, J=5.0Hz), 2.57 (2H, t, J=5.0Hz), 3.54 (2H, dd, J=7.2, 4.9Hz), 3.64 (2H, dd, J=7.2, 3.0Hz), 4.25-4.32 (1H, m), 4.50 (4H, s), 6.09 (1H, d, J=6.9Hz), 7.25-7.37 (10H, m).13C-NMR (CDCl3, 75MHz) delta (ppm): 175.8 (C), 171.6 (C), 137.7 (C×2), 128.3 (CHx4), 127.6 (CH×4), 127.6 (CH×2), 127.6 (C), 73.1 (CH2×2), 68.3 (CH2×2), 48.7 (CH), 30.6 (CH2), 29.6 (CH2). (Compound 16)1H-NMR (CDCl3, 400MHz) delta (ppm): 2.06 (2H, t, J=5.0Hz), 2.44 (2H, t, J=5.0Hz), 3.50-3.82 (14H, m), 4.09-4.16 (1H, m), 4.50 (2H, s), 4.50 (2H, s), 6.82 (1H, d, J=6.5Hz), 7.25-7.36 (20H, m).13C-NMR (CDCl3, 300MHz) delta (ppm): 175.3 (C), 172.0 (C), 137.9 (C×2), 137.7 (C×2), 128.2 (CH×4), 128.2 (CH×4), 127.7 (CH×4), 127.6 (CH×4), 127.5 (CH×2), 127.4 (CH×2), 78.9 (CH×2), 73.4 (CH2×2), 73.2 (CH2×2), 70.5 (CH2×2), 69.9 (CH2×2), 68.4 (CH2×2), 49.6 (CH), 30.1 (CH2), 30.0 (CH2). NHS (126.6 mg, 1.1 mmol), EDC (412.7 mg, 2.0 mmol) and triethylamine (0.11 ml, 0.8 mmol) were added to a tetrahydrofuran solution (45 ml) of each of Compounds 14 to 16 (1.0 mmol) in this order at room temperature, followed by refluxing for 2 to 4 hours. Then, 5% aqueous potassium hydrogensulfate solution was added to the reaction solution, followed by extraction with dichloromethane. The organic layer was washed with a saturated aqueous sodium hydrogencarbonate solution and a saturated brine in this order, dried over anhydrous magnesium sulfate and then filtered. The solvent was evaporated under reduced pressure, and the residue was purified by silica gel column chromatography (hexane:ethyl acetate = 1:10) to give Compounds 17 to 19, respectively (yield 53 to 90%). (Compound 17)1H-NMR (CDCl3, 400MHz) delta (ppm): 2.61 (2H, t, J=7.0Hz), 2.87 (4H, s), 3.19 (2H, t, J=7.0Hz), 3.49 (2H, t, J=5.0Hz), 3.59 (2H, t, J=5.0Hz), 4.55 (2H, s), 6.13-6.25 (1H, m), 7.31-7.42 (5H, m).13C-NMR (CDCl3, 75MHz) delta (ppm): 170.1 (C×2), 169.1 (C), 168.2 (C), 137.8 (C), 128.5 (CH×2), 127.9 (CH××2), 127.9 (CH), 73.2 (CH2), 68.9 (CH2), 39.5 (CH2), 30.6 (CH2), 26.8 (CH2), 25.5 (CH2×2). (Compound 18)1H-NMR (CDCl3, 400MHz) delta (ppm): 2.59 (2H, t, J=5.5Hz), 2.79 (4H, s), 2.98 (2H, t, J=5.5Hz), 3.54 (2H, dd, J=7.5, 5.0Hz), 3.64 (2H, dd, J=7.5, 3.0Hz), 4.27-4.34 (1H, m), 4.51 (4H, s), 5.95 (1H, d, J=6.8Hz), 7.25-7.39 (10H, m). 13C-NMR (CDCl3, 75MHz) delta (ppm): 169.3 (C), 168.7 (C×2), 167.9 (C), 137.9 (C×2), 128.2 (CH×4), 127.6 (CHx4), 127.5 (CH×2), 73.1 (CH2×2), 68.3 (CH2×2), 48.6 (CH), 30.7 (CH2), 26.7 (CH2), 25.5 (CH2×2). (Compound 19)1H-NMR (CDCl3, 400MHz) delta (ppm): 2.12 (2H, t, J=5.8Hz), 2.77-2.82 (6H, m), 3.51-3.82 (14H, m), 4.09-4.17 (1H, m), 4.50 (2H, s), 4.51 (2H, s), 6.68 (1H, d, J=7.0Hz), 7.27-7.35 (20H, m).13C-NMR (CDCl3, 75MHz) delta (ppm): 169.2 (C), 68.7 (C×2), 167.8 (C), 138.0 (C×2), 137.8 (C×2), 128.3 (CH×4), 128.2 (CH×4), 127.7 (CH×4), 127.6 (CH×4), 127.4 (CH×4), 79.0 (CH×2), 73.4 (CH2×2), 73.3 (CH2×2), 70.6 (CH2×2), 70.0 (CH2×2), 68.5 (CH2×2), 49.4 (CH), 29.8 (CH2), 26.5 (CH2), 25.0 (CH2×2). N-(8-aminooctyl)benzamide hydrochloride (compound Ra-H·HCl) was synthesized by the method described in Synthesis, 917 (1988). Compound Ra-H·HCl (284.8 mg, 1.0 mmol) and triethylamine (0.14 ml, 1.0 mmol) were added to a tetrahydrofuran solution (20 ml) of each of Compounds 17 to 19 and 6 (1.0 mmol) in this order at room temperature, followed by stirring at the same temperature for 3 to 6 hours. Then, 5% aqueous potassium hydrogensulfate solution was added to the reaction solution, followed by extraction with chloroform. The organic layer was washed with a saturated aqueous sodium hydrogencarbonate solution and a saturated brine in this order, dried over anhydrous magnesium sulfate and then filtered. The solvent…

Statistics shows that 2-(Benzyloxy)-1-ethanamine is playing an increasingly important role. we look forward to future research findings about 38336-04-8.

Reference:
Patent; KYOWA HAKKO KOGYO CO., LTD.; Tecno Network Shikoku Co.,Ltd.; EP1550651; (2005); A1;,
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Simple exploration of C9H13NO

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 38336-04-8, name is 2-(Benzyloxy)-1-ethanamine, A new synthetic method of this compound is introduced below., Quality Control of 2-(Benzyloxy)-1-ethanamine

Example 25; 5-cvclopropyl-2-(4-fluorophenyl)-6-(N-((2-hvdroxy-1 ,2-oxaborolan-4- yl)methyl)methylsulfonamido)-N-(2-hvdroxyethyl)benzofuran-3-carboxamideStep 1: N-(2-(benzyloxy)ethyl)-5-cyclopropyl-2-(4-fluorophenyl)-6- (methylsulfonamido)benzofuran-3-carboxamide5-Cyclopropyl-2-(4-fluorophenyl)-6-(methylsulfonamido)benzofuran-3-carboxylic acid (1 .0 g, 2.568 mmol) was stirred in dry DMF (15 mL) at ambient temperature with DIPEA (0.730 g, 5.650 mmol) and HATU (1.71 g, 3.082 mmol). After stirring for 15 minutes, benzyloxymethanamine (1 .552 mg, 10.272 mmol) in 15 mL of THF was added. The reaction mixture was stirred for another 2 hours and diluted with EtOAc (30 mL) and water (30 mL). The organic layer was separated and the aqueous layer was extracted with EtOAc (30 mL x2). The combined organic layers were washed with brine (30 mL), dried over anhydrous Na2S04, filtered and concentrated in vacuo. The residue was purified by columnchromatography (eluting with 0-50% ethyl acetate in petroleum) to give N-(2- (benzyloxy)ethyl)-5-cyclopropyl-2-(4-fluorophenyl)-6-(methylsulfonamido)benzofuran-3- carboxamide (1.4 g, crude, 104% yield).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; GLAXO GROUP LIMITED; JOHNS, Brian Alvin; SHOTWELL, John Brad; HAIGH, David; WO2012/67663; (2012); A1;,
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New downstream synthetic route of C9H13NO

According to the analysis of related databases, 38336-04-8, the application of this compound in the production field has become more and more popular.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 38336-04-8, name is 2-(Benzyloxy)-1-ethanamine, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 2-(Benzyloxy)-1-ethanamine

General procedure: Ethyl 2-(4-chloro-3-nitrophenyl)-2-methylpropanoate (3a)(16.15 g, 0.0594 mol), 4 (27.77 g, 0.149 mol), K2CO3 (28.69 g,0.208 mol), KI (0.99 g, 5.94 mmol), TBAB (1.91 g, 5.94 mmol) and150 mL DMSO were added into a round-bottomed flask. The mixturewas heated to 120 C for 24 h then cooling to room temperature.The reaction mixture was diluted with saturated NH4Claqueous solution (250 mL) and extracted with CH2Cl2 (450 mL).The combined organic layer was washed with brine (300 mL), driedover anhydrous sodium sulfate, filtered, and concentrated in vacuo.The residue was purified by silica gel column chromatography (PE:EtOAc = 4:1) to give compound 5a (15.82 g) as yellow oil in 69%yields.

According to the analysis of related databases, 38336-04-8, the application of this compound in the production field has become more and more popular.

Reference:
Article; Chen, Dongxing; Shi, Jinyu; Liu, Jing; Zhang, Xueying; Deng, Xiaoying; Yang, Yanyan; Cui, Shuang; Zhu, Qihua; Gong, Guoqing; Xu, Yungen; Bioorganic and Medicinal Chemistry; vol. 25; 2; (2017); p. 458 – 470;,
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Research on new synthetic routes about 38336-04-8

According to the analysis of related databases, 38336-04-8, the application of this compound in the production field has become more and more popular.

Related Products of 38336-04-8, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 38336-04-8 as follows.

To a stirred mixture of 7-bromo-4-chloro-3-nitroquinoline (20 g, 69.57 mmol, 1 equiv) and 2-(benzyloxy)ethan-l-amine(12.0 g, 79.30 mmol, 1.14 equiv) in DCM(400 mL) was added TEA(10.6 g, 104.35 mmol, 1.50 equiv) at room temperature under nitrogen atmosphere. The resulting mixture was stirred for 16 h at room temperature under nitrogen atmosphere. The resulting mixture was concentrated under vacuum. This resulted in N-[2-(benzyloxy)ethyl]-7-bromo-3-nitroquinolin-4- amine(30 g) as a yellow crude solid. LC-MS: (ES, m/z): [M+H]+ = 402.2/404.2.

According to the analysis of related databases, 38336-04-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; INNATE TUMOR IMMUNITY, INC.; GLICK, Gary; GHOSH, Shomir; ROUSH, William R.; OLHAVA, Edward James; O’MALLEY, Daniel; (222 pag.)WO2018/152396; (2018); A1;,
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The important role of 38336-04-8

The synthetic route of 38336-04-8 has been constantly updated, and we look forward to future research findings.

38336-04-8, name is 2-(Benzyloxy)-1-ethanamine, belongs to ethers-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. HPLC of Formula: C9H13NO

A mixture of e-1 (0.0037 mol) and e-2 (0.0151 mol) was stirred at 60C for 2 hours, then purified by column chromatography over silica gel (eluent: CH2CyCH3OH (98/2); 15mum). The pure fractions were collected and the solvent was evaporated. Yield: 1 g of intermediate e-3 (100%).

The synthetic route of 38336-04-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; TIBOTEC PHARMACEUTICALS LTD; WO2006/136561; (2006); A1;,
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Brief introduction of 38336-04-8

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(Benzyloxy)-1-ethanamine, other downstream synthetic routes, hurry up and to see.

Adding a certain compound to certain chemical reactions, such as: 38336-04-8, name is 2-(Benzyloxy)-1-ethanamine, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 38336-04-8, Product Details of 38336-04-8

To a solution of 3-hydroxy-2,2-dimethylpropanoic acid (2.36 g, 20 mmol), 2-(benzyloxy)ethanamine (3.02 g, 20 mmol), and HOBt (2.71 g, 20 mmol) in dry dichloromethane (100 mL) was added EDCI (3.82 g, 20 mmol) at room temperature under nitrogen. The reaction mixture was then stirred at room temperature under nitrogen overnight. The reaction was quenched with brine, and extracted with EtOAc (3*). The combined organic layers were washed with saturated NaHCO3 solution, dilute HCl, brine, and dried over Na2SO4. After evaporation of the solvent, the residue was purified by chromatography on silica gel eluting with 40% EtOAc in hexanes to give the title compound as colorless oil (4.89 g) in 97% yield. MS 252 (MH+).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(Benzyloxy)-1-ethanamine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; SENOMYX, INC.; Tachdjian, Catherine; Karanewsky, Donald; Tang, Xiao Qing; Liu, Hanghui; US2015/245642; (2015); A1;,
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