Related Products of 38336-04-8, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 38336-04-8 as follows.
To a stirred mixture of 7-bromo-4-chloro-3-nitroquinoline (20 g, 69.57 mmol, 1 equiv) and 2-(benzyloxy)ethan-l-amine(12.0 g, 79.30 mmol, 1.14 equiv) in DCM(400 mL) was added TEA(10.6 g, 104.35 mmol, 1.50 equiv) at room temperature under nitrogen atmosphere. The resulting mixture was stirred for 16 h at room temperature under nitrogen atmosphere. The resulting mixture was concentrated under vacuum. This resulted in N-[2-(benzyloxy)ethyl]-7-bromo-3-nitroquinolin-4- amine(30 g) as a yellow crude solid. LC-MS: (ES, m/z): [M+H]+ = 402.2/404.2.
According to the analysis of related databases, 38336-04-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; INNATE TUMOR IMMUNITY, INC.; GLICK, Gary; GHOSH, Shomir; ROUSH, William R.; OLHAVA, Edward James; O’MALLEY, Daniel; (222 pag.)WO2018/152396; (2018); A1;,
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