Category: 102503-23-1

Adding a certain compound to certain chemical reactions, such as: 102503-23-1, name is 1-(2,4-Dimethoxyphenyl)-N-methylmethanamine, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 102503-23-1, HPLC of Formula: C10H15NO2

Sodium hydride (60% in oil, 2.23 g, 55.8 mmol) was washed twice with n-hexane and suspended in THF (180 mL). A solution of 1-(2,4-dimethoxyphenyl)-N-methylmethanamine (9.09 g, 50.2 mmol) in THF (10 mL) was added dropwise to this suspension at 0 C, and then the mixture was stirred at 60 C for 18 h. After cooled to 0 C, a solution of compound 15 (9.64 g, 45.4 mmol) in THF (10 mL) was added dropwise, and then the mixture was stirred at the same temperature for 1 h. Ice-cooled solution of NaCl were added, and the mixture was extracted with EtOAc. The extract was washed successively with a solution of NH4Cl, a solution of NaHCO3, H2O and brine, dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure. The residue was purified by basic silica gel column chromatography (EtOAc) to obtain compound 16 (16.8 g, 99%) as a yellow oil. 1H-NMR (CDCl3) d 2.24 (3H, s), 3.51 (2H, s), 3.54 (2H, s), 3.79 (3H, s), 3.80 (3H, s), 6.45 (1H, s), 6.42-6.50 (1H, m), 6.68 (1H, dd, J = 4.7 Hz, 3.6 Hz), 7.18-7.29 (2H, m), 7.98 (1H, ddd, J = 4.5 Hz, 1.9 Hz, 1.5 Hz), 8.25 (1H, ddd, J = 10.2 Hz, 8.0 Hz, 1.9 Hz), 8.67 (1H, s).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Article; Nishida, Haruyuki; Fujimori, Ikuo; Arikawa, Yasuyoshi; Hirase, Keizo; Ono, Koji; Nakai, Kazuo; Inatomi, Nobuhiro; Hori, Yasunobu; Matsukawa, Jun; Fujioka, Yasushi; Imanishi, Akio; Fukui, Hideo; Itoh, Fumio; Bioorganic and Medicinal Chemistry; vol. 25; 13; (2017); p. 3447 – 3460;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 102503-23-1, name is 1-(2,4-Dimethoxyphenyl)-N-methylmethanamine belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Quality Control of 1-(2,4-Dimethoxyphenyl)-N-methylmethanamine

Into a vial was added the [B] 4-bromo-2-fluoro-N-thiazol-2-yl-benzenesulfonamide (170 mg, 0.00050 mol), sodium tert-butoxide (117 mg, 0.00121 mol), 9,9-dimethyl-4,5-bis(diphenylphosphino)xanthene (18 mg, 0.000030 mol), Tris(dibenzylideneacetone)dipalladium(0) (9.3 mg, 0.000010 mol) and 1,4-dioxane (1.58 mL, 0.0202 mol). Argon was bubbled for 15 minutes. Into the reaction was added the [2,4-dimethoxy-benzyl)-methyl-amine (110 mg, 0.00061 mol) and the reaction mixture was heated at 100 C. overnight. The reaction mixture was cooled to room temperature then filtered over Celite. The filtrate was concentrated to give the crude compound as a yellow solid that was used in the next step without purification

The synthetic route of 102503-23-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Icagen; US2009/23740; (2009); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 102503-23-1, name is 1-(2,4-Dimethoxyphenyl)-N-methylmethanamine, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C10H15NO2

General procedure: N-(2,4-dimethoxybenzyl)-N-methyl-3-phenylprop-2-yn-1-amine (5a). CuI (20 mg, 0.10 mmol) was added to a solution of phenylacetylene(510.6 mg, 5.0 mmol), HCHO (36% aq., 2 mL),N-methyl(2,4-dimethoxybenzyl)amine (1.09 g, 6.0 mmol) in DMSO (10.0mL). The resulting yellow green solution was stirred at room temperatureovernight and then diluted with H2O (10 mL), extracted with Et2O (15 mL x 3). The combined extractswas washed with H2O (2 x), brine (2 x) respectively, dried over Na2SO4, filtered, concentrated. Theresultant yellow oil was purified through flash column chromatography (silica gel, EtOAc/Hex = 1:6 to1:3) to give the product (5a, 1.14 g, 96%).

According to the analysis of related databases, 102503-23-1, the application of this compound in the production field has become more and more popular.

Reference:
Article; Yang, Miao; Odelberg, Shannon J.; Tong, Zongzhong; Li, Dean Y.; Looper, Ryan E.; Tetrahedron; vol. 69; 27-28; (2013); p. 5744 – 5750;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Application of 102503-23-1, The chemical industry reduces the impact on the environment during synthesis 102503-23-1, name is 1-(2,4-Dimethoxyphenyl)-N-methylmethanamine, I believe this compound will play a more active role in future production and life.

Vinylmagnesium bromide (17.7 mL of a IN solution in THF, 17.7 mmol) was added to a solution of 5 (2.00 g, 8.84 mmol) in dry THF (30 mL) at 0 C. The brown solution was warmed to r.t. for 1 h then a solution of N-methyl-2,4-dimethoxybenzylamine (4.00 g, 22.0 mmol) in THF (10 mL), and water (10 mL) were added. The solution was stirred at r.t. for 1 h, then partitioned between EtOAc and water. The solution was dried and evaporated to give a brown oil, which was chromatographed. Elution with EtOAc/hexanes gave fore fractions, then elution with EtOAc gave 7 (2.27 g, 68%) as a light yellow oil. 1H NMR (CDC13) delta 7.13 (d, J = 8.9 Hz, 1H), 6.73 (s, 2H), 6.44-6.41 (m, 2H), 3.59 (s, 6H), 3.88 (s, 3H), 3.53 (s, 3H), 3.50 (s, 2H), 3.12 (t, J = 7.0 Hz, 1H), 2.84 (t, J = 7.0 Hz, 2H), 2.26 (s, 3H). Found: [M+H]=375.3

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-(2,4-Dimethoxyphenyl)-N-methylmethanamine, other downstream synthetic routes, hurry up and to see.

Adding a certain compound to certain chemical reactions, such as: 102503-23-1, name is 1-(2,4-Dimethoxyphenyl)-N-methylmethanamine, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 102503-23-1, HPLC of Formula: C10H15NO2

Sodium hydride (60% in oil, 2.23 g, 55.8 mmol) was washed twice with n-hexane and suspended in THF (180 mL). A solution of 1-(2,4-dimethoxyphenyl)-N-methylmethanamine (9.09 g, 50.2 mmol) in THF (10 mL) was added dropwise to this suspension at 0 C, and then the mixture was stirred at 60 C for 18 h. After cooled to 0 C, a solution of compound 15 (9.64 g, 45.4 mmol) in THF (10 mL) was added dropwise, and then the mixture was stirred at the same temperature for 1 h. Ice-cooled solution of NaCl were added, and the mixture was extracted with EtOAc. The extract was washed successively with a solution of NH4Cl, a solution of NaHCO3, H2O and brine, dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure. The residue was purified by basic silica gel column chromatography (EtOAc) to obtain compound 16 (16.8 g, 99%) as a yellow oil. 1H-NMR (CDCl3) d 2.24 (3H, s), 3.51 (2H, s), 3.54 (2H, s), 3.79 (3H, s), 3.80 (3H, s), 6.45 (1H, s), 6.42-6.50 (1H, m), 6.68 (1H, dd, J = 4.7 Hz, 3.6 Hz), 7.18-7.29 (2H, m), 7.98 (1H, ddd, J = 4.5 Hz, 1.9 Hz, 1.5 Hz), 8.25 (1H, ddd, J = 10.2 Hz, 8.0 Hz, 1.9 Hz), 8.67 (1H, s).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Electric Literature of 102503-23-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 102503-23-1 name is 1-(2,4-Dimethoxyphenyl)-N-methylmethanamine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

b) 1-(2,4-dimethoxyphenyl)-N-methyl-N-[S-methyl-N-(2,2,2-trifluoroethyl)-sulfonimidoyl] methanamineCaution: t-BuOCl is light sensitive (work in a dark hood) and reacts violently with rubber, do not use rubber septum.To a stirring solution of N-(2,2,2-trifluoroethyl)methanesulfinamide (1.5 g, 9.31 mmol, (0249) Eq: 1.00) in dry tetrahydrofurane (THF) (50 ml) at -78 C was quickly added tert-butyl hypochlorite (1.06 g, 1.11 ml, 9.77 mmol, Eq: 1.05) and the mixture was stirred at -78 C for 10 min. 1-(2,4-dimethoxyphenyl)-N-methylmethanamine (2.02 g, 11.2 mmol, Eq: 1.2) (CAS 102503-23-1) in THF (10 ml) were added dropwise to the reaction mixture at -78C followed by triethylamine (1.88 g, 2.59 ml, 18.6 mmol, Eq: 2.0) and stirred at -78 C for 10 min. The cooling bath was replaced by an ice bath and the mixture was stirred at 0 C for 1 h, then at 22 C for 30 min. Saturated aqueous sodium hydrogen carbonate (NaHCO3,-solution was added and stirred at room temperature for 10 min. After that the mixture was poured cautiously into 1N aqueous HCl solution, diluted with ethyl acetate, and the phases were separated. The organic layer was washed with brine, dried over sodium sulfate (Na2SO4), filtered and evaporated to dryness. The crude material was purified by flash chromatography (silica gel, 40 g, 25% to 60% ethyl acetate (EtOAc) in heptane) to yield the title compound as a white solid (2.56 g; 80.8%). MS (ESI): m/z= 341.2 [M+H]+

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-(2,4-Dimethoxyphenyl)-N-methylmethanamine, and friends who are interested can also refer to it.

Synthetic Route of 102503-23-1,Some common heterocyclic compound, 102503-23-1, name is 1-(2,4-Dimethoxyphenyl)-N-methylmethanamine, molecular formula is C10H15NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: N-(2,4-dimethoxybenzyl)-N-methyl-3-phenylprop-2-yn-1-amine (5a). CuI (20 mg, 0.10 mmol) was added to a solution of phenylacetylene(510.6 mg, 5.0 mmol), HCHO (36% aq., 2 mL),N-methyl(2,4-dimethoxybenzyl)amine (1.09 g, 6.0 mmol) in DMSO (10.0mL). The resulting yellow green solution was stirred at room temperatureovernight and then diluted with H2O (10 mL), extracted with Et2O (15 mL x 3). The combined extractswas washed with H2O (2 x), brine (2 x) respectively, dried over Na2SO4, filtered, concentrated. Theresultant yellow oil was purified through flash column chromatography (silica gel, EtOAc/Hex = 1:6 to1:3) to give the product (5a, 1.14 g, 96%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-(2,4-Dimethoxyphenyl)-N-methylmethanamine, its application will become more common.

Reference:
Article; Yang, Miao; Odelberg, Shannon J.; Tong, Zongzhong; Li, Dean Y.; Looper, Ryan E.; Tetrahedron; vol. 69; 27-28; (2013); p. 5744 – 5750;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthetic Route of 102503-23-1, The chemical industry reduces the impact on the environment during synthesis 102503-23-1, name is 1-(2,4-Dimethoxyphenyl)-N-methylmethanamine, I believe this compound will play a more active role in future production and life.

General procedure: N-(2,4-dimethoxybenzyl)-N-methyl-3-phenylprop-2-yn-1-amine (5a). CuI (20 mg, 0.10 mmol) was added to a solution of phenylacetylene(510.6 mg, 5.0 mmol), HCHO (36% aq., 2 mL),N-methyl(2,4-dimethoxybenzyl)amine (1.09 g, 6.0 mmol) in DMSO (10.0mL). The resulting yellow green solution was stirred at room temperatureovernight and then diluted with H2O (10 mL), extracted with Et2O (15 mL x 3). The combined extractswas washed with H2O (2 x), brine (2 x) respectively, dried over Na2SO4, filtered, concentrated. Theresultant yellow oil was purified through flash column chromatography (silica gel, EtOAc/Hex = 1:6 to1:3) to give the product (5a, 1.14 g, 96%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-(2,4-Dimethoxyphenyl)-N-methylmethanamine, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Yang, Miao; Odelberg, Shannon J.; Tong, Zongzhong; Li, Dean Y.; Looper, Ryan E.; Tetrahedron; vol. 69; 27-28; (2013); p. 5744 – 5750;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Related Products of 102503-23-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 102503-23-1 as follows.

Reference Example 60; 1- (2, 4-dimethoxyphenyl) -N- { [4-fluoro-5- (2-fluoropyridin-3-yl) – lH-pyrrol-3-yl]methyl }-N-methylmethanamine; Sodium hydride (60% in oil, 2.23 g) was washed twice with hexane and suspended in tetrahydrofuran (180 mL) . To the suspension was added dropwise a solution of l-(2,4- dimethoxyphenyl) -N-methylmethanamine (9.09 g) in tetrahydrofuran (10 mL) at 0C. After the completion of the dropwise addition, the mixture was stirred at 600C for 18 hr. The reaction mixture was cooled to 0C, a solution of 3- (4, 4- difluoro-3-methylene-3, 4-dihydro-2H-pyrrol-5-yl) -2- fluoropyridine (9.64 g) in tetrahydrofuran (10 mL) was added dropwise, and the mixture was stirred at the same temperature for 1 hr. Ice water and saturated brine were added, and the mixture was extracted with ethyl acetate. The extract was washed successively with saturated aqueous ammonium chloride solution, saturated aqueous sodium hydrogen carbonate solution, water and saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The residue was purified by basic silica gel column chromatography (eluent: ethyl acetate) to give the title compound as a yellow oil (yield 16.8 g, 97%) . 1H-NMR (CDCl3) delta: 2.24(3H,s), 3.51(2H,s), 3.54(2H,s), 3.79(3H,s), 3.80(3H,s), 6.45(lH,s), 6.42-6.50 (IH,m) , 6.68(lH,dd, J=4.7,3.6Hz) , 7.18-7.29 (2H,m) ,7.98 ( IH, ddd, J=4.5, 1.9, 1.5Hz) , 8.25 (IH, ddd, J=IO .2 , 8.0, 1.9Hz) , 8.67(1HzS) .

According to the analysis of related databases, 102503-23-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; WO2008/108380; (2008); A2;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Electric Literature of 102503-23-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 102503-23-1, name is 1-(2,4-Dimethoxyphenyl)-N-methylmethanamine belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: N-(2,4-dimethoxybenzyl)-N-methyl-3-phenylprop-2-yn-1-amine (5a). CuI (20 mg, 0.10 mmol) was added to a solution of phenylacetylene(510.6 mg, 5.0 mmol), HCHO (36% aq., 2 mL),N-methyl(2,4-dimethoxybenzyl)amine (1.09 g, 6.0 mmol) in DMSO (10.0mL). The resulting yellow green solution was stirred at room temperatureovernight and then diluted with H2O (10 mL), extracted with Et2O (15 mL x 3). The combined extractswas washed with H2O (2 x), brine (2 x) respectively, dried over Na2SO4, filtered, concentrated. Theresultant yellow oil was purified through flash column chromatography (silica gel, EtOAc/Hex = 1:6 to1:3) to give the product (5a, 1.14 g, 96%).

The synthetic route of 1-(2,4-Dimethoxyphenyl)-N-methylmethanamine has been constantly updated, and we look forward to future research findings.

Reference:
Article; Yang, Miao; Odelberg, Shannon J.; Tong, Zongzhong; Li, Dean Y.; Looper, Ryan E.; Tetrahedron; vol. 69; 27-28; (2013); p. 5744 – 5750;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem