Electric Literature of 102503-23-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 102503-23-1 name is 1-(2,4-Dimethoxyphenyl)-N-methylmethanamine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
b) 1-(2,4-dimethoxyphenyl)-N-methyl-N-[S-methyl-N-(2,2,2-trifluoroethyl)-sulfonimidoyl] methanamineCaution: t-BuOCl is light sensitive (work in a dark hood) and reacts violently with rubber, do not use rubber septum.To a stirring solution of N-(2,2,2-trifluoroethyl)methanesulfinamide (1.5 g, 9.31 mmol, (0249) Eq: 1.00) in dry tetrahydrofurane (THF) (50 ml) at -78 C was quickly added tert-butyl hypochlorite (1.06 g, 1.11 ml, 9.77 mmol, Eq: 1.05) and the mixture was stirred at -78 C for 10 min. 1-(2,4-dimethoxyphenyl)-N-methylmethanamine (2.02 g, 11.2 mmol, Eq: 1.2) (CAS 102503-23-1) in THF (10 ml) were added dropwise to the reaction mixture at -78C followed by triethylamine (1.88 g, 2.59 ml, 18.6 mmol, Eq: 2.0) and stirred at -78 C for 10 min. The cooling bath was replaced by an ice bath and the mixture was stirred at 0 C for 1 h, then at 22 C for 30 min. Saturated aqueous sodium hydrogen carbonate (NaHCO3,-solution was added and stirred at room temperature for 10 min. After that the mixture was poured cautiously into 1N aqueous HCl solution, diluted with ethyl acetate, and the phases were separated. The organic layer was washed with brine, dried over sodium sulfate (Na2SO4), filtered and evaporated to dryness. The crude material was purified by flash chromatography (silica gel, 40 g, 25% to 60% ethyl acetate (EtOAc) in heptane) to yield the title compound as a white solid (2.56 g; 80.8%). MS (ESI): m/z= 341.2 [M+H]+
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-(2,4-Dimethoxyphenyl)-N-methylmethanamine, and friends who are interested can also refer to it.