Category: 1978-39-8

Reference of 1978-39-8, The chemical industry reduces the impact on the environment during synthesis 1978-39-8, name is 5-Fluoro-2-methoxyaniline, I believe this compound will play a more active role in future production and life.

Step (c): Preparation of 1-(3-fluoro-6-methoxyphenyl)piperazine 5-fluoro-2-methoxyaniline (0.092 mol) and bis(2-chloroethyl)aminehydrochloride (0.1 mol) in xylene (300 ml) was refluxed with stirring for a period of 20 hrs. Water was added to the reaction and the organic layer discarded. The aqueous layer was basified with sodium hydroxide and extracted with methylene chloride (2*100 ml). The methylene chloride extract was dried (sodium carbonate), filtered, and concentrated. Residual material was distilled to provide 8.8 g (45% yield) of piperazine product, b.p. 111-114 C. 0.15 mmHg:

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Fluoro-2-methoxyaniline, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Bristol-Myers Company; US4585773; (1986); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Reference of 1978-39-8, These common heterocyclic compound, 1978-39-8, name is 5-Fluoro-2-methoxyaniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

8-Fluoro-5-methoxy-2H-benzoreiri ,2,41thiadiazin-3(4H)-one 1 ,1 -dioxide (lnt-12) (2152) A 250 mL round-bottomed flask was charged with chlorosulfonyl isocyanate (2.058 ml) in nitropropane (20 ml) to give a colorless solution at -40 C under nitrogen. After 10 min, a solution of 5-fluoro-2-methoxyaniline (2.72 g) in nitropropane (10 ml) was added to the reaction mixture. After 10 min, the reaction was warmed to 0 C. After 1 h, aluminum chloride (3.21 g) was added to the reaction mixture. After 5 min, the reaction mixture was warmed to 1 10 C. After 30 min, the reaction mixture was poured in ice/water (400 mL) and stirred for 1 h. The solids were filtered and washed with water. The solids were placed in drying oven overnight at 50 C to obtain the titled compound (2.3 g). LCMS m/z 247.1 (M+H).

The synthetic route of 1978-39-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; ADAMS, Jerry Leroy; ATOR, Laura E.; DUFFY, Kevin J.; GRAYBILL, Todd L.; KIESOW, Terence John; LIAN, Yiqian; MOORE, Michael Lee; RALPH, Jeffrey M.; RIDGERS, Lance Howard; (370 pag.)WO2017/98421; (2017); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

These common heterocyclic compound, 1978-39-8, name is 5-Fluoro-2-methoxyaniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: 5-Fluoro-2-methoxyaniline

Step (b): Preparation of 1-(4-fluoro-2-methoxyphenyl)piperazine Reaction of bis(2-chloroethyl)amine hydrochloride (0.11 mol) with 5-fluoro-2-methoxyaniline (0.01 mol) according to Step (c) of Example XII, provided 19.5 g (95% yield) of the piperazine intermediate used without further purification.

The synthetic route of 5-Fluoro-2-methoxyaniline has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Bristol-Myers Company; US4585773; (1986); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1978-39-8, name is 5-Fluoro-2-methoxyaniline, A new synthetic method of this compound is introduced below., name: 5-Fluoro-2-methoxyaniline

To a THF (20 mL) solution of 5-fluoro-2-methoxyaniline (1.76 g), a THF (30 mL) solution of pyridinium bromide perbromide (4.36 g) was added dropwise under ice-cooling, and the reaction solution was agitated for 30 minutes at room temperature. The solid which deposited from the reaction mixture was separated by filtering and the solid was washed by THF. After the obtained solid was dissolved with water and ethyl acetate, the aqueous layer was neutralized with a saturated sodium bicarbonate water, and the organic layer was partitioned. After the obtained organic layer was washed with a saturated saline solution, it was dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The residue was purified by silica gel chromatography (elution solvent:hexane-ethyl acetate system), and 1.83 mg of the title compound was obtained. 1H-NMR (CDCl3) delta (ppm): 3.82 (s, 3H), 3.91 (brs, 2H), 6.50 (d, J=9.6 Hz, 1H), 6.84 (d, J=6.0 Hz, 1H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Eisai Co., Ltd.; US2006/4013; (2006); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Adding a certain compound to certain chemical reactions, such as: 1978-39-8, name is 5-Fluoro-2-methoxyaniline, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1978-39-8, Computed Properties of C7H8FNO

General procedure: A primary amine (17.8 mmol) was dissolved/suspended in acetonitriie (50 ml) and then heated to reflux temperature. Then 2,6-lutidine (20 ml, 173 mmol) was added. A solution of DMP3C-BF4 (5.04 g, 9.88 mmol) was dissolved in acetonitriie (250 ml) and then added slowly dropwise (1 drop per 5-10 s) to the hot solution of the phenol compound. The addition was allowed to proceed overnight (16 h). The red reaction mixture was analyzed by MALDI-TOF (dithranol matrix) and this analysis indicated that no starting material was present. The reaction mixture was allowed to cool down, and then poured into an acidified KPF6 solution (10 ml 2 M HCI in 1500 ml 0.2 M KPF6) upon vigorous stirring. A red precipitate formed and the suspension was gen-tly stirred for 15 min and then filtered . The filtrate was washed with HCI solution (2 M), then with water, and finally with heptane until the heptane phase was nearly colorless. The red sticky mass was dissolved in a minimum of CH2CI2 through the filter. The product was precipitated with heptane and filtered off and washed with heptane (2 x 100 ml). The product was dissolved in a minor amount of acetonitrile and poured onto diethyl ether upon stirring. The red precipitate was allowed to form for 15 min, filtered off, and then washed with ether (2 x 100 ml). The red sticky product was collected and dissolved in CH2CI2. The CH2CI2 was removed by evaporation yielding 17 g of red-gray fine powder. The red powder was suspended in pure water and stirred overnight. The red powder was filtered off, washed with water, and sucked dry. The sticky red product was dissolved in acetonitrile through the funnel and then the solvent was removed by evaporation. The red powder was collected and dried on an oil pump for 1 day.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; KØBENHAVNS UNIVERSITET; LAURSEN, Bo V.; ROSENBERG, Martin; SØRENSEN, Thomas Just; WO2015/58777; (2015); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Related Products of 1978-39-8, These common heterocyclic compound, 1978-39-8, name is 5-Fluoro-2-methoxyaniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

a) 4-fluoro-2-isocvanato-1 -methoxybenzene5-fluoro-2-methoxyaniline (5.0 g, 35 mmols) was dissolved in dioxane (70 mL) and a solution of trichloromethyl chloroformate (2.11 mL) in the same solvent (20 mL) was added dropwise. It was stirred at 6O0C for 20 hours. It was concentrated in vacuo and diethyl ether was added. The solid precipitated was filtered off and the mother liquors were concentrated in vacuo to give the title compound (4.66 g).

The synthetic route of 1978-39-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ALMIRALL PRODESFARMA, SA; WO2006/133802; (2006); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Related Products of 1978-39-8, These common heterocyclic compound, 1978-39-8, name is 5-Fluoro-2-methoxyaniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A suspension of 5-fluoro-2-methoxy-phenylamine (3.3 g, 23 mmol), 3-oxo-butyric acid ethyl ester (3.0 g, 23 mmol), acetic acid (120 muL), and drierite (12.0 g) in ethanol (20 mL) was heated to reflux for 5 d. The reaction mixture was cooled to room temperature and filtered. The filtrate was concentrated in vacuo and purified by flash chromatography on silica gel (elution with EA/hexane 1 :3) to give crude 3-(5-fluoro-2-methoxy-phenylamino)-but-2- enoic acid ethyl ester.

Statistics shows that 5-Fluoro-2-methoxyaniline is playing an increasingly important role. we look forward to future research findings about 1978-39-8.

Reference:
Patent; JERINI AG; WO2008/116620; (2008); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Application of 1978-39-8, The chemical industry reduces the impact on the environment during synthesis 1978-39-8, name is 5-Fluoro-2-methoxyaniline, I believe this compound will play a more active role in future production and life.

Step (c): Preparation of 1-(3-fluoro-6-methoxyphenyl)piperazine 5-fluoro-2-methoxyaniline (0.092 mol) and bis(2-chloroethyl)aminehydrochloride (0.1 mol) in xylene (300 ml) was refluxed with stirring for a period of 20 hrs. Water was added to the reaction and the organic layer discarded. The aqueous layer was basified with sodium hydroxide and extracted with methylene chloride (2*100 ml). The methylene chloride extract was dried (sodium carbonate), filtered, and concentrated. Residual material was distilled to provide 8.8 g (45% yield) of piperazine product, b.p. 111-114 C. 0.15 mmHg:

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Fluoro-2-methoxyaniline, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Bristol-Myers Company; US4585773; (1986); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Related Products of 1978-39-8,Some common heterocyclic compound, 1978-39-8, name is 5-Fluoro-2-methoxyaniline, molecular formula is C7H8FNO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 2 (5) obtained in 2 – [[5- (4-hydroxy-3-methoxyphenyl)-4-(lH-pyrrol-1-yl)-4H-1,2,4-triazole -3 – yl] thio] acetic acid (200mg, 0.58mmol),1-hydroxybenzotriazole (80mg, 0.6mmol),1-ethyl-3- (3-dimethylaminopropyl) carbodiimide hydrochloride (120 mg, 0.6 mmol)Of N, N-dimethylformamide (4 ml)Was added triethylamine (0.18ml, 1.2mmol)When the 5-fluoro-2-methoxy aniline (0.08ml, 0.7mmol)Was stirred for 16 hours at room temperature added.It was extracted by the addition of 1N hydrochloric acid and ethyl acetate to the reaction solution. Further, the aqueous layer was extracted twice with ethyl acetate, the organic layer was dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure, the residue was purified by column (hexane: ethyl acetate = 1: 3-1: 5) to give N-(5-fluoro-2-methoxyphenyl) -2 – [[5- ( 4-hydroxy-3-methoxyphenyl) -4- (1H- pyrrol-1-yl) -4H-1,2,4- triazol-3-yl] thio] acetamide (30mg, 11%) a pale brown solid It was obtained as a.

The synthetic route of 1978-39-8 has been constantly updated, and we look forward to future research findings.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1978-39-8, name is 5-Fluoro-2-methoxyaniline belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 5-Fluoro-2-methoxyaniline

To a solution of compound Al (400 rng, 0.53 mrnoi) and 5-fluoro-2-rnethoxyaniline (150,7mg, 1.07 mmoi) intoluene (10 rnL) was added Ti(O-i] r)4 (151.6 mg, 0.53 mmoi). Themixture was stirred at 120 C over night under N2. The mixture was quenched with [120 (50 rnL) and extracted with DCM (20 mL x 3). The combined organic layer was dried over potassium carbonate, filtered and concentrated. The residue was purified by silica gel column chromatography (DCMMeOH = 15/i) to afford the crude products 29-1 and 29-2 (320 mg) as a yellow solid. LC-MS: m/z 89.4 [M+I-[.

The synthetic route of 1978-39-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; AGRIMETIS, LLC; CALABRESE, Andrew; (110 pag.)WO2018/132288; (2018); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem