Related Products of 1978-39-8, These common heterocyclic compound, 1978-39-8, name is 5-Fluoro-2-methoxyaniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A suspension of 5-fluoro-2-methoxy-phenylamine (3.3 g, 23 mmol), 3-oxo-butyric acid ethyl ester (3.0 g, 23 mmol), acetic acid (120 muL), and drierite (12.0 g) in ethanol (20 mL) was heated to reflux for 5 d. The reaction mixture was cooled to room temperature and filtered. The filtrate was concentrated in vacuo and purified by flash chromatography on silica gel (elution with EA/hexane 1 :3) to give crude 3-(5-fluoro-2-methoxy-phenylamino)-but-2- enoic acid ethyl ester.
Statistics shows that 5-Fluoro-2-methoxyaniline is playing an increasingly important role. we look forward to future research findings about 1978-39-8.
Reference:
Patent; JERINI AG; WO2008/116620; (2008); A1;,
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