Category: 876-32-4

Related Products of 876-32-4,Some common heterocyclic compound, 876-32-4, name is 4-Methoxy-N-methylbenzylamine hydrochloride, molecular formula is C9H14ClNO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

In a sealed tube, mixture of benzamide 24b (38 mg, 0.11 mmol), formaldehyde (37% in water, 0.043 mL, 0.55 mmol), 1-(4-methoxyphenyl)-N-methylmethanamine hydrochloride (102 mg, 0.55 mmol), and 1N NaOH (0.5 mL) in H2O:THF (1 mL:0.5 mL) was heated at 65 C for 2 hours. After cooling to room temperature, the reaction mixture was diluted with ethyl acetate, washed with brine, dried over Na2SO4, and concentrated, then purified by column chromatography to afford the pure product (28 mg, 57% yield) as off white solid. 1H NMR (CDCl3, 300 MHz) delta: 7.73 (d, J= 1.8 Hz, 1H), 7.49 (d, J= 8.7 Hz, 1H), 7.36 (dd, J= 1.8, 8.7 Hz, 1H), 7.23 (d, J= 8.7 Hz, 2H), 7.20- 7.13 (m, 1H), 6.91-6.84 (m, 1H), 6.85 (d, J= 8.7 Hz, 2H), 6.17 (bs, 1H), 5.35 (s, 2H), 4.38 (d, J= 6.3 Hz, 2H), 3.79 (s, 3H), 3.59 (s, 2H), 2.32 (s, 3H).

The synthetic route of 876-32-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY; UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY; LAVOIE, Edmond J.; PARHI, Ajit; ZHANG, Yongzheng; PILCH, Daniel S.; KAUL, Malvika; WO2013/142712; (2013); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 876-32-4 as follows. name: 4-Methoxy-N-methylbenzylamine hydrochloride

In a sealed tube, mixture of benzamide 3a (38 mg, 0.11 mmol), formaldehyde (37% in water, 0.043 mL, 0.55 mmol), l-(4-methoxyphenyl)-N-methylmethanamine hydrochloride (102 mg, 0.55 mmol), and 1 N NaOH (0.5 mL) in H2O:THF (1 mL: 0.5 mL) was heated at 65 C for 2 hours. After cooling to room temperature, the reaction mixture was diluted with ethyl acetate, washed with brine, dried over Na2S04, and concentrated, then purified by column chromatography to afford the pure product (28 mg, 51% yield) as off white solid. 1H NMR (CDCI3, 300 MHz) 6: 8.00 (d, J= 1.8 Hz, 1H), 7.82 (d, J= 8.7 Hz, 1H), 7.40 (dd, J= 2.1, 8.7 Hz, 1H), 7.23 (d, J= 8.7 Hz, 2H), 7.14- 7.07 (m, 1H), 6.90-6.83 (m, 1H), 6.85 (d, J= 7.8 Hz, 2H), 6.20 (bs, 1H), 5.50 (s, 2H), 4.39 (d, J= 6.3 Hz, 2H), 3.79 (s, 3H), 3.60 (s, 2H), 2.33 (s, 3H).

According to the analysis of related databases, 876-32-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY; UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY; LAVOIE, Edmond J.; PARHI, Ajit; ZHANG, Yongzheng; PILCH, Daniel S.; KAUL, Malvika; WO2013/142712; (2013); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem