In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 876-32-4 as follows. name: 4-Methoxy-N-methylbenzylamine hydrochloride
In a sealed tube, mixture of benzamide 3a (38 mg, 0.11 mmol), formaldehyde (37% in water, 0.043 mL, 0.55 mmol), l-(4-methoxyphenyl)-N-methylmethanamine hydrochloride (102 mg, 0.55 mmol), and 1 N NaOH (0.5 mL) in H2O:THF (1 mL: 0.5 mL) was heated at 65 C for 2 hours. After cooling to room temperature, the reaction mixture was diluted with ethyl acetate, washed with brine, dried over Na2S04, and concentrated, then purified by column chromatography to afford the pure product (28 mg, 51% yield) as off white solid. 1H NMR (CDCI3, 300 MHz) 6: 8.00 (d, J= 1.8 Hz, 1H), 7.82 (d, J= 8.7 Hz, 1H), 7.40 (dd, J= 2.1, 8.7 Hz, 1H), 7.23 (d, J= 8.7 Hz, 2H), 7.14- 7.07 (m, 1H), 6.90-6.83 (m, 1H), 6.85 (d, J= 7.8 Hz, 2H), 6.20 (bs, 1H), 5.50 (s, 2H), 4.39 (d, J= 6.3 Hz, 2H), 3.79 (s, 3H), 3.60 (s, 2H), 2.33 (s, 3H).
According to the analysis of related databases, 876-32-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY; UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY; LAVOIE, Edmond J.; PARHI, Ajit; ZHANG, Yongzheng; PILCH, Daniel S.; KAUL, Malvika; WO2013/142712; (2013); A1;,
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