Category: 18800-30-1

Adding a certain compound to certain chemical reactions, such as: 18800-30-1, name is 1-Bromo-4-(2-bromoethoxy)benzene, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 18800-30-1, Application In Synthesis of 1-Bromo-4-(2-bromoethoxy)benzene

KOr-Bu (14.0 g, 125 mmol) was added in portions over 10 min to l-bromo-4- (2-bromoethoxy)benzene (19.9 g, 100 mmol see step (a) above) in THF (120 mL) at 0 0C. After 16 h at rt, water (400 mL) was added and the mixture was extracted with petroleum ether (4 x 100 mL). The combined extracts were washed with brine, dried (Na2SO4), concentrated and distilled under vacuum to yield the subtitle compound (11.5 g, 58%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Bromo-4-(2-bromoethoxy)benzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; BIOLIPOX AB; WO2006/77364; (2006); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthetic Route of 18800-30-1, The chemical industry reduces the impact on the environment during synthesis 18800-30-1, name is 1-Bromo-4-(2-bromoethoxy)benzene, I believe this compound will play a more active role in future production and life.

General procedure: 6-Hydroxyphthalide (9) (0.33 mmol) was dissolved in N,N-dimethylformamide (DMF; 3 mL) and stirred over K2CO3 (1.14 mmol) for 5 min. The appropriately substituted alkyl bromide (0.37 mmol) was added and the reaction mixture was stirred for 12 h at 50-100 ºC. The K2CO3 was removed by filtration and the reaction mixture was dried in a stream of air. The resulting residue was recrystallized from ethanol to yield the C6-substituted phthalide analogues 6a-r.1 Benzylaminophthalide (6s) was synthesized according to the same procedure from 6-aminophthalide (8) and benzyl bromide

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Bromo-4-(2-bromoethoxy)benzene, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Strydom, Belinda; Bergh, Jacobus J.; Petzer, Jacobus P.; Bioorganic and Medicinal Chemistry Letters; vol. 23; 5; (2013); p. 1269 – 1273;,
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Reference of 18800-30-1, The chemical industry reduces the impact on the environment during synthesis 18800-30-1, name is 1-Bromo-4-(2-bromoethoxy)benzene, I believe this compound will play a more active role in future production and life.

1 -Bromo-4-vinyloxybenzene KOf-Bu (14.0 g, 125 mmol) was added in portions over 10 min to a solution of l-bromo-4-(2-bromoethoxy)benzene (19.9 g, 100 mmol see step (a) above) in THF (120 mL) at 0 0C. After 16 h at rt and dilution with water (400 mL), the mixture was extracted with petroleum ether (4×100 mL). The combined extracts were washed with brine, dried (Na2SO4) and concentrated. Vacuum distillation afforded the sub-title compound (11.5 g, 58%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Bromo-4-(2-bromoethoxy)benzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; BIOLIPOX AB; WO2006/77367; (2006); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Adding a certain compound to certain chemical reactions, such as: 18800-30-1, name is 1-Bromo-4-(2-bromoethoxy)benzene, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 18800-30-1, Computed Properties of C8H8Br2O

EXAMPLE 1 A mixture of 2.8 parts of 1-bromo-4-(2-bromoethoxy)benzene, 5 parts of cis-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-3-H1,2,4-triazol-3-one, 0.7 parts of potassium hydroxide and 100 parts of dimethyl sulfoxide was stirred for 4 hours at room temperature. The reaction mixture was poured into water. The product was extracted with dichloromethane. The extract was subsequently washed with water, dried, filtered and evaporated. The residue was purified by column chromatography over silica gel usinq a mixture of trichloromethane and methanol (99:1 by volume) as eluent. The pure fractions were collected and the eluent was evaporated. The residue was crystallized from a mixture of 2-propanone and 2,2′-oxybispropane. The product was filtered off and recrystallized from methylbenzene, yielding 5.2 parts (79%) of cis-2-[2-(4-bromophenoxy)ethyl]-4-[4-[ 4-[4-[[2-(2,4-dichlorophenyl)-2-(1 H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-3H-1,2,4-triazol-3-one; mp. 143.3 C. (compound 1).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Bromo-4-(2-bromoethoxy)benzene, and friends who are interested can also refer to it.

Reference:
Patent; Janssen Pharmaceutica, N.V.; US4791111; (1988); A;,
Ether – Wikipedia,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 18800-30-1, name is 1-Bromo-4-(2-bromoethoxy)benzene, A new synthetic method of this compound is introduced below., COA of Formula: C8H8Br2O

In a 100 ml two-necked flask, 40 ml of DMF was added,4- (2-bromoethoxy) -bromobenzene (9.48 g, 47 mmol)Potassium phthalimide (10.47 g, 56 mmol) was reacted at 90 C for 2 h.After the reaction, DMF was removed by steaming and then extracted three times with chloroform to combine the organic phase,Add the appropriate amount of anhydrous MgSO4, standing for half an hour. The MgSO4 was removed by filtration,The chloroform was removed by rotary distillation and purified by column chromatography (dichloromethane as eluent) to give a white solid,Yield 85%.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Nanjing Tech University; Gao Deqing; Pan Zhenhuan; Tong Tong; Li Bobo; Liu Minglun; Huang Wei; (9 pag.)CN106518691; (2017); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 18800-30-1, name is 1-Bromo-4-(2-bromoethoxy)benzene, A new synthetic method of this compound is introduced below., category: ethers-buliding-blocks

b) 52.0 g (186 mmol) 1-Bromo-4-(2-bromoethoxy)benzene are added to 300 mL THF and cooled to 0 C. Within 30 min 25.0 g (223 mmol) KOtBu are added to this mixture in several portions. Cooling is removed and the reaction mixture is stirred at rt over night. The reaction is quenched by the addition of water. The resulting mixture is extracted with EtOAc (2×). The organic phases are combined, washed with brine, dried over MgSO4 and the solvent is removed in vacuo. The resulting product is used without further purification.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; ROTH, Gerald Juergen; FLECK, Martin; LEHMANN-LINTZ, Thorsten; NOSSE, Bernd; US2013/143876; (2013); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

18800-30-1, name is 1-Bromo-4-(2-bromoethoxy)benzene, belongs to ethers-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Computed Properties of C8H8Br2O

l-Bromo-4-(2-bromoethoxy)benzene (95 mg, 0.34 mmol) was added to a mixture of N-[2-(3-azetidinyloxy)-5,6-dichloro-3-pyridinyl]-2-chloro-4-pyridinecarboxamide (i.e. the product of Step C) (100 mg, 0.28 mmol) and N,N-diisopropylethylamine (76 mL, 0.42 mmol) in acetonitrile (3 mL), and the reaction mixture was heated at 60 C overnight. The cooled solution was treated with saturated aqueous sodium bicarbonate solution (2 mL) and water (2 mL), and then diluted with dichloromethane before being filtered through a tube containing Celite diatomaceous filter aid, eluting with dichloromethane. The residue after concentration was purified by chromatography (silica gel, ethyl acetate to 5% methanol in ethyl acetate) to give the title product, a compound of the present invention, as a pale yellow oil (84 mg)..H NMR delta 8.88 (s, 1H), 8.62 (d, 1H), 8.28 (br s, 1H), 7.77 (d, 1H), 7.62 (d, 1H), 7.37 (d, 2H), 6.78 (d, 2H), 5.35 (m, 1H), 3.99 (t, 2H), 3.92 (t, 2H), 3.42 (br s, 2H), 2.95 (t, 2H).

The synthetic route of 18800-30-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; E. I. DU PONT DE NEMOURS AND COMPANY; CLARK, David Alan; LAHM, George, P.; WO2012/12366; (2012); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Adding a certain compound to certain chemical reactions, such as: 18800-30-1, name is 1-Bromo-4-(2-bromoethoxy)benzene, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 18800-30-1, Recommanded Product: 1-Bromo-4-(2-bromoethoxy)benzene

KOr-Bu (14.0 g, 125 mmol) was added in portions over 10 min to l-bromo-4- (2-bromoethoxy)benzene (19.9 g, 100 mmol see step (a) above) in THF (120 mL) at 0 0C. After 16 h at rt, water (400 mL) was added and the mixture was extracted with petroleum ether (4 x 100 mL). The combined extracts were washed with brine, dried (Na2SO4), concentrated and distilled under vacuum to yield the subtitle compound (11.5 g, 58%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Bromo-4-(2-bromoethoxy)benzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; BIOLIPOX AB; WO2006/77364; (2006); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthetic Route of 18800-30-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 18800-30-1, name is 1-Bromo-4-(2-bromoethoxy)benzene belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Step 1: tert-butyl 4-(2-(4-bromophenoxy)ethyl)-3-methylpiperazine-1-carboxylateToan 8mL scintillation vial were added 1-bromo-4-(2-bromoethoxy)benzene (2.80g, 10.0mmol), 4-N-Boc-2-methylpiperazine (2.00g, 10.0mmol), and cesium carbonate(7.5g, 20.0mmol) in anhydrous dimethylformamide (5.0 mL). Reaction slurry was stirred at RT for 48hrs, TLC and MS confirmingpresence of the desired intermediate. Quenched with water 20 (50mL) and extractedwith ethyl acetate(3x100mL). Organics were combined, washedwith additional water (50mL), brine (50mL), dried over Na2S04 and filtered. Solventwas removed and yellow oil was carried forward withoutpurification. ESI-LCMS m/z calculated for C18H27BrN203:expected 399.33;found 400.2 [M+Ht.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Bromo-4-(2-bromoethoxy)benzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; THE INSTITUTE FOR DRUG DELIVERY; CORMAN, Michael L.; HUNGERFORD, William M.; GOLEBIOWSKI, Adam; BECKETT, Raymond P.; MAZUR, Marzena; OLEJNICZAK, Sylwia; OLCZAK, Jacek; WO2015/95701; (2015); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Electric Literature of 18800-30-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 18800-30-1, name is 1-Bromo-4-(2-bromoethoxy)benzene belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: b) 52.0 g (186 mmol) of 1 -bromo-4-(2-bromoethoxy)benzene is added to 300 ml THF and chilled to 0 C. Within 30 min 25.0 g (223 mmol) KOtBu are added to this mixture in several portions. The cooling bath is removed and the reaction mixture is stirred at r.t. over night. The reaction is queched by the addition of water. The resulting mixture is extracted with EtOAc (2x). The org. phases are combined, washed with sat. aq. NaCI solution, dried with MgSO4 and the solvent is removed in vacuo. The resulting product is used without further purification.

The synthetic route of 1-Bromo-4-(2-bromoethoxy)benzene has been constantly updated, and we look forward to future research findings.