Synthetic Route of 18800-30-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 18800-30-1, name is 1-Bromo-4-(2-bromoethoxy)benzene belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Step 1: tert-butyl 4-(2-(4-bromophenoxy)ethyl)-3-methylpiperazine-1-carboxylateToan 8mL scintillation vial were added 1-bromo-4-(2-bromoethoxy)benzene (2.80g, 10.0mmol), 4-N-Boc-2-methylpiperazine (2.00g, 10.0mmol), and cesium carbonate(7.5g, 20.0mmol) in anhydrous dimethylformamide (5.0 mL). Reaction slurry was stirred at RT for 48hrs, TLC and MS confirmingpresence of the desired intermediate. Quenched with water 20 (50mL) and extractedwith ethyl acetate(3x100mL). Organics were combined, washedwith additional water (50mL), brine (50mL), dried over Na2S04 and filtered. Solventwas removed and yellow oil was carried forward withoutpurification. ESI-LCMS m/z calculated for C18H27BrN203:expected 399.33;found 400.2 [M+Ht.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Bromo-4-(2-bromoethoxy)benzene, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; THE INSTITUTE FOR DRUG DELIVERY; CORMAN, Michael L.; HUNGERFORD, William M.; GOLEBIOWSKI, Adam; BECKETT, Raymond P.; MAZUR, Marzena; OLEJNICZAK, Sylwia; OLCZAK, Jacek; WO2015/95701; (2015); A1;,
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