Category: 104-92-7

Related Products of 104-92-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 104-92-7 name is 1-Bromo-4-methoxybenzene, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: n-BuLi (1.2 mmol) was added to a THF (6 ml) solution ofaryl bromide (1 mmol) at -78C. After stirring for 1 h at same temperature, a THF solution of MOM-Cl or BOM-Cl (1.1 mmolin 4 ml dry THF) was added dropwise to it. Stirring was continuedfor another 1 h at same temperature and slowlywarmed to 0C over another 1 h and quenched with saturatedaqueous ammonium chloride solution. The organic layerwas separated and aqueous layer was extracted with diethylether. The combined organic layer was dried (Na2SO4) andevaporated. Column chromatographic purification gave thedesired product.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Bromo-4-methoxybenzene, and friends who are interested can also refer to it.

Reference:
Article; Panda, Biswajit; Journal of the Indian Chemical Society; vol. 95; 8; (2018); p. 981 – 985;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 104-92-7, name is 1-Bromo-4-methoxybenzene, A new synthetic method of this compound is introduced below., Computed Properties of C7H7BrO

General procedure: In a nitrogen filled glove box, PdCl2(CH3CN)2 (3.25mg, 0.010025mmol) and 2a (11.8mg, 0.0375mmol) or 2b (17.7mg, 0.0375mmol) were measured into a 1 dram vial containing a small stir bar. The vial was sealed with a screw cap and septum and removed from the glovebox before adding Cy2NMe (235muL, 1.10mmol), aryl halide (1.00mmol), alkyl acetylene (1.10mmol), and 1:1 water/acetonitrile (2mL). The reaction vial was placed in a preheated oil bath at 80C and stirred until it reached completion as determined by gas chromatography (2-12h). Upon completion, the reaction mixture was taken into diethyl ether, washed with brine solution, dried with anhydrous magnesium sulfate, and filtered. The excess organic solvent was removed under reduced pressure, and the crude residues were taken into methylene chloride and evaporated onto silica gel under reduced pressure. Once dry, the silica gel mixture was used in column chromatography.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Moore, Jane N.; Laskay, Nicholas M.; Duque, Kevin S.; Kelley, Steven P.; Rogers, Robin D.; Shaughnessy, Kevin H.; Journal of Organometallic Chemistry; vol. 777; (2015); p. 16 – 24;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 104-92-7, name is 1-Bromo-4-methoxybenzene, A new synthetic method of this compound is introduced below., Application In Synthesis of 1-Bromo-4-methoxybenzene

General procedure: A mixture of Ni(cod)2 (0.050 mmol), SIPr·HCl (0.050 mmol),KOt-Bu (0.050 mmol), and CPME was stirred at 100 C for 30min. To this was added NaOAc (0.85 mmol), aryl bromide 1(0.50 mmol), and N-TMS-carbazole 2 (0.65 mmol). The reactionmixture was quenched with H2O. The aqueous layer wasextracted with Et2O and washed with brine. The combinedorganic layers were dried over anhydrous MgSO4. After concentrationin vacuo, the residue was purified by flash chromatographyon silica gel or preparative TLC to afford N-aryl-carbazoles 3.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Minami, Yasunori; Komiyama, Takeshi; Shimizu, Kenta; Uno, Shu-Ichi; Hiyama, Tamejiro; Goto, Osamu; Ikehira, Hideyuki; Synlett; vol. 28; 18; (2017); p. 2407 – 2410;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Electric Literature of 104-92-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 104-92-7, name is 1-Bromo-4-methoxybenzene, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: To a stirred solution of 1.0 mmol of aryl halide in 4 mL of DMF,1.0 mmol of terminal alkyne, 1.5 mmol of piperidine and 0.2 mol%of Pd/Fe3O4NPs were added and the mixture was heated on anoil bath at 110C for 24 h under inert atmosphere (N2). After com-pletion of the reaction (as monitored by TLC), the reaction mixturewas cooled to room temperature and the catalyst was separatedusing a magnetic separator. The solvent was evaporated at reducedpressure, and the residue was subjected to gel permeation chro-matography to afford pure products. All the products are knowncompounds and the spectral data and melting points were identicalto those reported in the literature.

The chemical industry reduces the impact on the environment during synthesis 1-Bromo-4-methoxybenzene. I believe this compound will play a more active role in future production and life.

Reference:
Article; Nasrollahzadeh, Mahmoud; Mohammad Sajadi; Rostami-Vartooni, Akbar; Khalaj, Mehdi; Journal of Molecular Catalysis A: Chemical; vol. 396; (2015); p. 31 – 39;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 104-92-7, name is 1-Bromo-4-methoxybenzene, This compound has unique chemical properties. The synthetic route is as follows., Safety of 1-Bromo-4-methoxybenzene

Pd(OAc)2/2-Catalyzed Amination of Aryl and Heteroaryl Bromides (Table 3).General Procedure: An oven-dried Schlenk flask equipped with a magnetic stirring bar was charged with Pd(OAc)2 (x mol %, see Table 3) and NaO-t-Bu (1.5 mmol). Amine (1.2 mmol) and aryl bromide (1.0 mmol) were also added at this time, if they were solids. The flask was capped with a rubber septum, evacuated and then flushed with argon. This cycle was repeated three times. Ligand 2 (2x mol %, see Table 3) was then added via syringe from a stock solution. Aryl bromide (if a liquid, 1.0 mmol), amine (if a liquid, 1.2 mmol) and toluene (3 mL) were then successively added by syringe. The reaction mixture was heated at the temperature indicated in Table 3 until the starting material had been completely consumed as judged by TLC (15-20 hours). The mixture was then cooled to room temperature, adsorbed onto silica gel and then purified by column chromatography (hexanes/ethyl acetate as eluent).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 104-92-7.

Reference:
Patent; Iowa State University Research Foundation, Inc.; US7385058; (2008); B1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthetic Route of 104-92-7, The chemical industry reduces the impact on the environment during synthesis 104-92-7, name is 1-Bromo-4-methoxybenzene, I believe this compound will play a more active role in future production and life.

General procedure: To a stirred solution of 1.0 mmol of aryl halide in 4 mL of DMF,1.0 mmol of terminal alkyne, 1.5 mmol of piperidine and 0.2 mol%of Pd/Fe3O4NPs were added and the mixture was heated on anoil bath at 110C for 24 h under inert atmosphere (N2). After com-pletion of the reaction (as monitored by TLC), the reaction mixturewas cooled to room temperature and the catalyst was separatedusing a magnetic separator. The solvent was evaporated at reducedpressure, and the residue was subjected to gel permeation chro-matography to afford pure products. All the products are knowncompounds and the spectral data and melting points were identicalto those reported in the literature

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Bromo-4-methoxybenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Nasrollahzadeh, Mahmoud; Mohammad Sajadi; Rostami-Vartooni, Akbar; Khalaj, Mehdi; Journal of Molecular Catalysis A: Chemical; vol. 396; (2015); p. 31 – 39;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem