Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 104-92-7, name is 1-Bromo-4-methoxybenzene, A new synthetic method of this compound is introduced below., Computed Properties of C7H7BrO
General procedure: In a nitrogen filled glove box, PdCl2(CH3CN)2 (3.25mg, 0.010025mmol) and 2a (11.8mg, 0.0375mmol) or 2b (17.7mg, 0.0375mmol) were measured into a 1 dram vial containing a small stir bar. The vial was sealed with a screw cap and septum and removed from the glovebox before adding Cy2NMe (235muL, 1.10mmol), aryl halide (1.00mmol), alkyl acetylene (1.10mmol), and 1:1 water/acetonitrile (2mL). The reaction vial was placed in a preheated oil bath at 80C and stirred until it reached completion as determined by gas chromatography (2-12h). Upon completion, the reaction mixture was taken into diethyl ether, washed with brine solution, dried with anhydrous magnesium sulfate, and filtered. The excess organic solvent was removed under reduced pressure, and the crude residues were taken into methylene chloride and evaporated onto silica gel under reduced pressure. Once dry, the silica gel mixture was used in column chromatography.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Moore, Jane N.; Laskay, Nicholas M.; Duque, Kevin S.; Kelley, Steven P.; Rogers, Robin D.; Shaughnessy, Kevin H.; Journal of Organometallic Chemistry; vol. 777; (2015); p. 16 – 24;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem