Formula: C10H10O5On November 30, 1982 ,《Acid-labile resin linkage agents for use in solid phase peptide synthesis》 appeared in International Journal of Peptide & Protein Research. The author of the article were Sheppard, Robert C.; Williams, Brian J.. The article conveys some information:
Acid-labile peptide-resin linkage agents I (R = H, OMe) were prepared from 4-formylphenol (II) and 3-methoxyphenol (III), resp. Thus, III was formylated with POCl3/DMF to give benzaldehyde IV (R1 = H), which was treated with ClCH2CO2H in the presence of aqueous NaOH to give IV (R1 = CH2CO2H), which was reduced by NaBH4 to give I (R = OMe). II was treated with ClCH2CO2H to give 4-HCOC6H4OCH2CO2H, which was reduced by NaBH4 to give I (R = H). I (R = OMe) is suitable for the preparation of peptide fragments having tert-Bu-based side-chain protective groups. In addition to this study using 2-(4-Formyl-3-methoxyphenoxy)acetic acid, there are many other studies that have used 2-(4-Formyl-3-methoxyphenoxy)acetic acid(cas: 84969-24-4Formula: C10H10O5) was used in this study.
2-(4-Formyl-3-methoxyphenoxy)acetic acid(cas: 84969-24-4) belongs to ethers.Ethers do have nonbonding electron pairs on their oxygen atoms, and they can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.Formula: C10H10O5
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem