Category: 41406-00-2

Adding a certain compound to certain chemical reactions, such as: 41406-00-2, name is 3-Isopropoxyaniline, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 41406-00-2, Formula: C9H13NO

EXAMPLE 272C 6-(3-Isopropoxybenzeneaminocarbonyl)-2-quinolinylnitrile A solution of 3-isopropoxyaniline (0.332 g, 2.2 mmol) in dry dichloromethane (5 mL) was treated with trimethylaluminum (1.1 mL of 2 M solution in hexanes) under N2 at room temperature. After 20 minutes, methyl 2-cyano-6-quinolinecarboxylate (0.414 g, 2 mmol) was added in one portion and the reaction mixture was allowed to stir at room temperature for three days. The reaction mixture was quenched with 2 M HCl (vigorous reaction) and allowed to stir for 10 minutes. The precipitated product was filtered off, washed with dichloromethane and water, and dried in a vacuum oven to afford 0.23 g (35%) of product sufficiently pure for the next step. MS m/z 332 (M+H)+, m/z 349 (M+NH4)+; 1H NMR (300 MHz, DMSO-d6) delta 1.30 (d, 6H), 4.58 (septet, 1H), 6.68-6.72 (m, 1H), 7.29 (t, 1H), 7.34-7.39 (m, 1H), 7.47-7.49 (m, 1H), 8.15 (d, 1H), 8.27 (d, 1H), 8.38 (dd, 1H), 8.73 (d, 1H), 8.84 (d, 1H), 10.56 (s, 1H, NH); IR (mic) v 3434, 2233, 1677;

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Isopropoxyaniline, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Abbott Laboratories; US6284796; (2001); B1;,
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Some common heterocyclic compound, 41406-00-2, name is 3-Isopropoxyaniline, molecular formula is C9H13NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. category: ethers-buliding-blocks

General procedure: 2-Hydroxynaphthalene-1-carboxylic acid or 1-hydroxynaphthalene-2-carboxylic acid (5.30 mmol) and appropriate alkoxyaniline (5.30 mmol) were suspended in 30 mL of dry chlorobenzene. Phosphorous trichloride (2.65 mmol) was added dropwise, and reacting mixture was heated in the microwave reactor for 15 min at 130 C using infrared flask-surface control of temperature. Solvent was evaporated in vacuum; residue solid was washed with 2M HCl and crystallized from aqueous ethanol. If necessary, column chromatography was used for further purification (mobile phase DCM:MeOH 19:1).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 41406-00-2, its application will become more common.

Reference:
Article; Gonec, Tomas; Pospisilova, Sarka; Kauerova, Tereza; Kos, Jiri; Dohanosova, Jana; Oravec, Michal; Kollar, Peter; Coffey, Aidan; Liptaj, Tibor; Cizek, Alois; Jampilek, Josef; Molecules; vol. 21; 8; (2016);,
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Adding a certain compound to certain chemical reactions, such as: 41406-00-2, name is 3-Isopropoxyaniline, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 41406-00-2, Computed Properties of C9H13NO

Example 3; General Procedure for Synthesis of Second Purine SNAr Products; The mono-SNAr product 14 (40 mg, 0.12 mmol) and 3-isopropoxyaniline (44 mul, 0.3 mmol) were added to a microwave vial, followed by the addition of isopropyl alcohol (IPA, 0.8 mL) and 4 drops of TFA. The mixture was irradiated in a microwave oven at 155 C. for 60 minutes to effect the desired reaction. After cooling the reaction vessel to room temperature, the volatiles were evaporated under reduced pressure. The residue was purified by reverse-phase high performance liquid chromatography (RP-HPLC), eluting with a gradient of acetonitrile-water to provide the desired product 129, racemic-(2-exo,3-exo-)-N6-[3-(dimethylamino)carbonylbicyclo[2.2.1]hept-5-en-2-yl)]-N2-(3-isopropoxyphenyl)-1H-purine-2,6-diamine.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; RIGEL PHARMACEUTICALS, INC.; US2007/142402; (2007); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 41406-00-2, name is 3-Isopropoxyaniline, A new synthetic method of this compound is introduced below., name: 3-Isopropoxyaniline

A mixture of 2,4-dichloro-5-methylpyrimidine (0.326 g, 2.0 mmol), 3-isopropoxyaniline (0.310 mL, 2.1 mmol), DIPEA (0.420 mL, 2.4 mmol), and iPrOH (2 mL) was allowed to react and worked up following the same procedure used to make RJ1-048, with the exception that no MeOH was added before workup and that the reaction was run overnight for 19.5 hours. The residue was then purified via flash chromatography, and the desired product RJl-058 was collected at hexanes/EtOAc 15-20% as a flaky caramel-colored solid (0.242 g, 44%). m.p. = 127 – 128 C. NMR (400 MHz, DMSO-ifc) delta 8.76 (s, 1H), 8.03 (s, 1H), 7.30 (t, / = 2.2 Hz, 1H), 7.25-7.13 (m, 2H), 6.64 (ddd, / = 8.0, 2.4, 1.1 Hz, 1H), 4.59^.50 (m, 1H), 2.15 (d, / = 0.6 Hz, 3H), 1.27 (d, / = 6.0 Hz, 6H). LRMS (ESI+) m/z 278.1 (M35C1+H)+, 280.1 (M37C1+H)+; HRMS (ESI+) m/z calculated for CwHieClNsO (M+H)+ 278.10547, found 278.10860.

The synthetic route of 41406-00-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; H. LEE MOFFITT CANCER CENTER & RESEARCH INSTITUTE, INC.; SCHOeNBRUNN, Ernst; LAWRENCE, Nicholas J.; LAWRENCE, Harshani R.; (293 pag.)WO2017/66428; (2017); A1;,
Ether – Wikipedia,
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Adding a certain compound to certain chemical reactions, such as: 41406-00-2, name is 3-Isopropoxyaniline, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 41406-00-2, Safety of 3-Isopropoxyaniline

To a stirred solution of 2,6,6-trimethylcyclohex-l-enecarbaldehyde (99.5 mg, 0.66 mmol) in methanol (2 mL) ) was added 3-isopropoxyaniline (99.5 mg, 0.66 mmol) followed by acetic acid (0.1 mL), and sodium cyanoborohydride (124.0 mg, 1.97 mmol). The reaction was stirred at room temperature for 2 hours. The reaction was quenched by addition of saturated aqueous ammonium chloride (5 mL) and the organic volatiles were evaporated under reduced pressure. The resulting mixture was diluted with ethyl acetate (30 mL) and the organic phase was washed with water (20 mL), saturated aqueous sodium bicarbonate (20 mL) and brine (20 mL), dried over anhydrous sodum sulfate and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent: petroleum ether/ethyl acetate = 90/1 ) to give the title compound as a colorless oil (137 mg, Yield: 72%). Rf = 0.6 (20:1 petroleum ether/ethyl acetate); H NMR (400 MHz, CDCI3) delta 7.05 (t, J = 8.0 Hz, 1 H), 6.24-6.18 (m, 2 H), 6.15-6.14 (m, 1 H), 4.56-4.50 (m, 1 H), 3.55 (s, 2 H), 3.30 (bs, 1 H), 1.97 (t, J = 6.2 Hz, 2 H), 1.66 (s, 3 H), 1.66-1.59 (m, 2 H), 1.50-1.43 (m, 2 H), 1.33 (d, J = 6.0 Hz, 6 H), .02 (s, 6 H) ppm; Mass spectrum (ESI +ve) m/z 288 (M + H+).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Isopropoxyaniline, and friends who are interested can also refer to it.

Reference:
Patent; BIKAM PHARMACEUTICALS, INC.; QUACH, Tan; BERMAN, Judd; GARVEY, David, S.; WO2013/81642; (2013); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

These common heterocyclic compound, 41406-00-2, name is 3-Isopropoxyaniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Formula: C9H13NO

EXAMPLE A; 3-(3-Isopropoxy-phenyl)-2-thioxo-2,3-dhydr-1H-quinazolin-4-one To a solution of 3-isopropoxy aniline (6.0 g, 40 mmol) in 150 ml of CHCl3 was added dropwise thiophos-gene (2.81 ml, 44 mmol) at 0 C. After the addition of thiophosgene, triethylamine (7.0 ml, 48 mmol) was added slowly and the reaction mixture was stirred for 2 hours at room temperature. It was then concentrated and diluted with 200 ml of ethyl acetate. The triethylamine hydrochloride salt was filtered off and the filtrate was concentrated to yield crude 3-isopropoxyphenyl isothiocyanate.The crude 3-isopropoxyphenyl isothiocyanate was dissolved in 150 ml of acetic acid, and anthranilic acid (6.04 g, 44 mmol) was added. The resulting reaction mixture was refluxed for 16 hours and then cooled to room temperature. The white solid was separated which was filtered to yield 9.0 g of the title compound (72.1%) mp 288-290 C.

The synthetic route of 3-Isopropoxyaniline has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Warner-Lambert Company; US6897213; (2005); B1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthetic Route of 41406-00-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 41406-00-2, name is 3-Isopropoxyaniline belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Reference Example 13-1; To Compound 1 (1.00 g) were added Compound 2 (3.00 ml) and trifluoroacetic acid (0.05 ml), and the mixture was heated to reflux for 24 hours. The reaction mixture was cooled, and then concentrated under reduced pressure. To a solution of the residue in ethanol (20 ml) was added sodium borohydride (1.00 g) under ice-cooling, and the mixture was stirred for an hour, and then heated to reflux for 2 hours. The reaction mixture was cooled, and then thereto was added water. The solvent was concentrated to about halves under reduced pressure, and extracted with ethyl acetate. The extracted layer was washed with saturated saline, and dried over anhydrous magnesium sulfate, and then the solvent was distilled away under reduced pressure. The residue was purified by silica gel column chromatography (eluent n-hexane-ethyl acetate 100:0 to 50:50 gradient) to give Compound 3 (0.96 g) as a pale yellow oily substance.MS (APCI) 166 [M+H]+

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Isopropoxyaniline, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Yamaguchi, Tetsuo; Ushirogochi, Hideki; Hirai, Miki; Imanishi, Yasuhiro; US2012/16117; (2012); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Related Products of 41406-00-2, A common heterocyclic compound, 41406-00-2, name is 3-Isopropoxyaniline, molecular formula is C9H13NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: Thiazole bisamide compounds were prepared in the same manner as in Examples 1-28 except that the R3 diphenyl ether group was substituted with a substituted phenyl group as shown in Table 5, The results of the prepared products of formula as (I-3), as well as the numbers of the prepared compounds, R1, R2 and R7 and the yields thereof are shown in Table 5. The intermediate of formula (II) (0.5 mmol), 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDCI, 0.6 mmol), hydroxybenzotriazole (HOBt, 0.6 mmol) was dissolved in 5 mL of N, N-dimethylformamide, the reaction temperature 25 deg. C 1h; Then, the reactant (0.6 mmol) represented by R3-NH2 was added to the above solution, the reaction temperature was 25 deg. C 72h; after completion of the reaction, the solvent was removed under reduced pressure, column chromatography to obtain the target product, thiazole bisamide compound.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Central China Normal University; Yang, Guangfu; Chen, Cheng; Chen, Yanqing; Xiong, Maoqian; (30 pag.)CN106316977; (2017); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 41406-00-2, name is 3-Isopropoxyaniline belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 41406-00-2

Example 75 Preparation of 2-fluoro-3-iodo-N-(3-isopropoxyphenyl)-4-methylbenzamideOxalyl chloride (2 M in DCM) (1832 mul, 3664 mumol) was added to a suspension of 2- fluoro-3-iodo-4-methylbenzoic acid (684 mg, 2443 mumol) in DCM (20 mL) at 0 0C. One drop of DMF (cat) was added. The mixture was stirred at RT for 3 h. Solvent was removed under vacuum. DCM (5 mL) was added to the residue and the mixture was added slowly to a mixture of 3-isopropoxybenzenamine (540 muL, 3664 mumol) and triethylamine (681 muL, 4885 mumol) in DCM (10 mL) at 0 0C. The mixture was stirred at RT overnight and then water (50 mL) was added. The mixture was extracted with DCM (3 x 50 mL). The combined organic layers were washed with brine (100 mL) and dried over sodium sulfate. The solvent was removed in vacuo and the residue was purified by preparative TLC eluting with 10% EtOAc / hexane to give the title compound (683 mg, 68%). MS (M+H)+ 414.

The synthetic route of 41406-00-2 has been constantly updated, and we look forward to future research findings.

41406-00-2, name is 3-Isopropoxyaniline, belongs to ethers-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. HPLC of Formula: C9H13NO

EXAMPLE 1 Synthesis of o-trifluoromethyl-m’-isopropoxybenzoic anilide. To a tetrahydrofuran solution containing 1.5 g (0.01 mole) of m-isopropoxyaniline and 1.2 g (0.011 mole) of triethylamine, while being cooled in ice water, was added slowly 2.3 g (0.011 mole) of o-trifluoromethylbenzoyl chloride. After having been stirred for 2 hours at room temperature, the reaction mixture was freed from triethylamine hydrochloride by filtration and then from the solvent by distillation under reduced pressure. The residue was recrystallized from n-hexane to obtain 2.9 g (91% yield) of the intended product melting at 95 to 97 C.

The synthetic route of 41406-00-2 has been constantly updated, and we look forward to future research findings.