In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 41406-00-2, name is 3-Isopropoxyaniline belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 41406-00-2
Example 75 Preparation of 2-fluoro-3-iodo-N-(3-isopropoxyphenyl)-4-methylbenzamideOxalyl chloride (2 M in DCM) (1832 mul, 3664 mumol) was added to a suspension of 2- fluoro-3-iodo-4-methylbenzoic acid (684 mg, 2443 mumol) in DCM (20 mL) at 0 0C. One drop of DMF (cat) was added. The mixture was stirred at RT for 3 h. Solvent was removed under vacuum. DCM (5 mL) was added to the residue and the mixture was added slowly to a mixture of 3-isopropoxybenzenamine (540 muL, 3664 mumol) and triethylamine (681 muL, 4885 mumol) in DCM (10 mL) at 0 0C. The mixture was stirred at RT overnight and then water (50 mL) was added. The mixture was extracted with DCM (3 x 50 mL). The combined organic layers were washed with brine (100 mL) and dried over sodium sulfate. The solvent was removed in vacuo and the residue was purified by preparative TLC eluting with 10% EtOAc / hexane to give the title compound (683 mg, 68%). MS (M+H)+ 414.
The synthetic route of 41406-00-2 has been constantly updated, and we look forward to future research findings.