17715-69-4 Archives - Ethers-buliding-blocks

9/18/2021 News Analyzing the synthesis route of 17715-69-4

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Bromo-2,4-dimethoxybenzene, its application will become more common.

Application of 17715-69-4,Some common heterocyclic compound, 17715-69-4, name is 1-Bromo-2,4-dimethoxybenzene, molecular formula is C8H9BrO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A suspension of Pd2(dba)3 (6.9mg, 0.0075mmol), tBu3PHBF4 (8.7mg, 0.03mmol), KOH (42mg, 0.75mmol), aryl bromide 4 (0.36mmol) and tetralone 3 (0.3mmol) in a mixture of dioxane/water (4:1, v/v, 3mL) was degassed and heated under Ar and microwave irradiation (80W of initial power, 100°C, 40min, infrared probe). Then, the mixture was allowed to cool to rt, diluted in AcOEt, washed with saturated NH4Cl solution, dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure. The crude material was purified by silica gel chromatography. Dioxane quality is extremely important for the success of the reaction. Characterization of alpha-aryl-alpha-tetralones is given in Ref.[26].

Reference:
Article; Fernandes, Talita de A.; Costa, Paulo R. R.; Manvar, Dinesh; Basu, Amartya; Kaushik-Basu, Neerja; Domingos, Jorge L. O.; Nichols, Daniel Brian; European Journal of Medicinal Chemistry; vol. 112; (2016); p. 33 – 38;,
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10-Sep-21 News Analyzing the synthesis route of 17715-69-4

Statistics shows that 1-Bromo-2,4-dimethoxybenzene is playing an increasingly important role. we look forward to future research findings about 17715-69-4.

Application of 17715-69-4, These common heterocyclic compound, 17715-69-4, name is 1-Bromo-2,4-dimethoxybenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Statistics shows that 1-Bromo-2,4-dimethoxybenzene is playing an increasingly important role. we look forward to future research findings about 17715-69-4.

9/9/2021 News Application of 17715-69-4

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Adding a certain compound to certain chemical reactions, such as: 17715-69-4, name is 1-Bromo-2,4-dimethoxybenzene, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 17715-69-4, Safety of 1-Bromo-2,4-dimethoxybenzene

General procedure: Synthesis of 4′-methoxybiphenyl-4-carbonitrile. A reaction vessel equipped with filtration frit was charged with polystyrene resin-bound benzyl(di-tert-butyl)phosphonium chloride (6.20 mg, 4% mol, 100-200 mesh resin containing 1.60 mmol/g phosphonium hydrochloride) and flushed with argon. Next, 5mL of degassed dioxane was added followed by 20 mL of diisopropylamine and reaction mixture was agitated for 1 h at room temperature. Subsequently, the solvent was removed and the resin washed with degassed dioxane (3×5 mL). The resin was resupended in dioxane (5.0 mL) and Pd2(dba)3·CHCl3 (5.20 mg, 2% mol) added and the reaction mixture was agitated for 12 h at room temperature. The Pd-doped resin becomes black in colour. The solvent was removed and catalyst washed with degassed dioxane (3×5 mL). 4-Bromobenzonitrile (45.5 mg, 0.25 mmol), 4-methoxyphenylboronic acid (42.0 mg, 0.28 mmol), Cs2CO3 (179.2 mg, 0.55 mmol), 5 mL of degassed dioxane were added and the suspension agitated for 72h at room temperature. The solution was filtered and the Pd-doped catalyst re-suspended and washed with degassed dioxane (3 x 5 mL). Evaporation of the combined dioxane extracts under vacuum and purification by chromatography on silica gel (ethyl acetate/hexane 1:9) afforded the title compound (41 mg, 80%). All entries reported in table 2 were conducted under the above conditions.

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Reference:
Article; Ullah, Ehsan; McNulty, James; Sliwinski, Marcin; Robertson, Al; Tetrahedron Letters; vol. 53; 31; (2012); p. 3990 – 3993;,
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Research on new synthetic routes about C8H9BrO2

The synthetic route of 17715-69-4 has been constantly updated, and we look forward to future research findings.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 17715-69-4, name is 1-Bromo-2,4-dimethoxybenzene belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. COA of Formula: C8H9BrO2

n-BuLi (2.5 M in THF, 3.3 mL, 8.3 mmol) was added drop wise to a stirred solution of 1-bromo-2,4-dimethoxybenzene (7) (1.5 g, 6.9 mmol) in THF (15 mL) at -78 °C under N2 atmosphere. After 30 min, CO2 gas was passed through the solution during 45 min of time and the mixture was allowed to warm up to room temperature. THF was removed in vacuum and the mixture was treated with saturated NaHCO3 solution (40 mL). The water layer was washed with ethyl acetate (2*20 mL) and then acidified with conc. HCl. The mixture was extracted with ethyl acetate (2*75 mL). The organic layer was washed with water (2*30 mL), brine (30 mL), dried (Na2SO4), filtered and concentrated. Recrystallization from ethyl acetate produced 9 (1.15 g, 91percent) as white solid. Rf 0.3 (1:1 ethyl acetate:hexane); mp 103-105 °C (lit.22 107-109 °C); 1H NMR (CDCl3, 500MHz): delta 8.10 (d, 1H, J=9.0Hz, C6-H), 6.61 (dd, 1H, J=9.0, 2.0Hz, C5-H), 6.50 (d, 1H, J=2.0Hz, C3-H), 4.01 (s, 3H, OMe), 3.86 (s, 3H, OMe); 13C NMR (CDCl3, 125MHz): delta 179.9 (C), 165.2 (C), 160.2 (C), 135.2 (CH), 110.1 (C), 106.2 (CH), 98.5 (CH), 56.4 (CH3), 55.7 (CH3).

The synthetic route of 17715-69-4 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Pahari, Pallab; Saikia, Ujwal Pratim; Das, Trinath Prasad; Damodaran, Chendil; Rohr, Juergen; Tetrahedron; vol. 72; 23; (2016); p. 3324 – 3334;,
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Some scientific research about 17715-69-4

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Bromo-2,4-dimethoxybenzene, other downstream synthetic routes, hurry up and to see.

General procedure: A solution of 4-methoxybromobenzene (2.67 mmol)and cyclopent-2-en-1-one (3.2 mmol) in DMSO was stirred at ambient temperaturefor 10 min under nitrogen, and treated with Na2CO3 (8.01mmol) and tri-tert-butylphosphonium tetrafluoroborate (0.53 mmol).The reaction mixture was degassed with nitrogen for 10 min and treated withPd(PPh3)2Cl2 (0.13 mmol) and X-Phos (0.26mol), and stirred at 100 0C for 12 h. The reaction mixture was cooledto ambient temperature, diluted with water, and extracted with AcOEt (3 x 50ml). The combined organic layers were washed with brine, dried over anhydrousNa2SO4, and evaporated. Flash chromatograph on silica gel(AcOEt:cyclohexane 1:3) provided the Heck coupling product as brown solid (340mg, 68percent).

Reference:
Article; Gowala, Tarak Nath; Pabba, Jagadish; Tetrahedron Letters; vol. 56; 14; (2015); p. 1801 – 1804;,
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The origin of a common compound about 1-Bromo-2,4-dimethoxybenzene

The synthetic route of 1-Bromo-2,4-dimethoxybenzene has been constantly updated, and we look forward to future research findings.

Electric Literature of 17715-69-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 17715-69-4, name is 1-Bromo-2,4-dimethoxybenzene belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

The synthetic route of 1-Bromo-2,4-dimethoxybenzene has been constantly updated, and we look forward to future research findings.

Reference:
Article; Gowala, Tarak Nath; Pabba, Jagadish; Tetrahedron Letters; vol. 56; 14; (2015); p. 1801 – 1804;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Introduction of a new synthetic route about C8H9BrO2

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference of 17715-69-4, A common heterocyclic compound, 17715-69-4, name is 1-Bromo-2,4-dimethoxybenzene, molecular formula is C8H9BrO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A thermometer, a stirrer, a reflux condenser attached to the flask, and subjected to nitrogen gas purging, 1-bromo-2,4-dimethoxybenzene 110g, 257g IPA, and potassium carbonate added to the solution previously prepared by dissolving 139g to 107g water and the reaction vessel was stirred while nitrogen It is replaced, and then tetrakistriphenylphosphine palladium (0), adding to 5.9g, also 4-methoxy-phenylboronic acid to pre-IPA 109g 83g Solution was added dropwise to the dissolved. After 3 hours the reaction mixture was heated to reflux, added 500mL of water, separate the IPA layer, the water layer was Transferred to a separatory funnel, the toluene extract was added 500mL. An organic layer was washed with saturated sodium chloride solution each. Solvents in vacuo After distilling off the one, added 500mL of toluene, and the precipitate was separated by filtration, toluene was distilled off under reduced pressure. Methane to the obtained crude product Adding to come 200mL, taking over the precipitate, and dried 5 hours in a vacuum dryer of 50 , 2,4,4′- tree fertilization methoxy phenyl Gained 105g

Reference:
Patent; Dainippon Inc. & Chemicals; Yoshimoto, Yasuyo; Morinika, Kunihiro; Kinoshita, Hiroshi; (17 pag.)KR2016/8529; (2016); A;,
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Brief introduction of 1-Bromo-2,4-dimethoxybenzene

Application of 17715-69-4, The chemical industry reduces the impact on the environment during synthesis 17715-69-4, name is 1-Bromo-2,4-dimethoxybenzene, I believe this compound will play a more active role in future production and life.

General procedure: To a flask containing Mg turnings (0.29 g, 12 mmol) was added1-bromo-4-methylbenzene (1.37 g, 8.0 mmol) in THF (8 mL) at room temperature. After being stirred for 2 h, DMF (1.3 mL,12 mmol) was added to the reaction mixture. The obtained mixturewas stirred for 2 h at 0 ° C. Then, aq NH3 (7 mL, 28-30percent) and I2 (4.06 g, 16 mmol) were added to the reaction mixture. After beingstirred for 2 h at room temperature, the reaction mixture waspoured into satd aq Na2SO3 solution and was extracted with CHCl3 (3*30 mL). The organic layer was dried over Na2SO4 and filtered.After removal of the solvent, the residue was purified by shortcolumn chromatography on silica gel (eluent: hexane/ethylacetate=9:1, v/v) to provide pure 4-methyl-1-benzonitrile (0.77 g) in 82percent yield.

Reference:
Article; Ishii, Genki; Harigae, Ryo; Moriyama, Katsuhiko; Togo, Hideo; Tetrahedron; vol. 69; 5; (2013); p. 1462 – 1469;,
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The important role of 17715-69-4

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 17715-69-4.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 17715-69-4, name is 1-Bromo-2,4-dimethoxybenzene, This compound has unique chemical properties. The synthetic route is as follows., Safety of 1-Bromo-2,4-dimethoxybenzene

General procedure: A suspension of Pd2(dba)3 (6.9 mg, 0.0075 mmol), tBu3PHBF4 (8.7 mg,0.03 mmol), KOH (42 mg, 0.75 mmol), aryl bromide 9 (0.36 mmol) and tetralone 10(0.3 mmol) in a mixture of dioxane/water (4:1, v/v, 3 mL) was degassed and heated under Ar and microwave irradiation (80W of initial power, 100 °C, 40min, infrared probe). Then, the mixture was allowed to cool to rt, diluted in AcOEt, washed with saturated NH4Cl solution, dried over anhydrous Na2SO4,filtered and concentrated under reduced pressure. The crude material was purified by silica gel chromatography.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 17715-69-4.

Reference:
Article; Manvar, Dinesh; Fernandes, Talita De A.; Domingos, Jorge L.O.; Baljinnyam, Erdenechimeg; Basu, Amartya; Junior, Eurides F.T.; Costa, Paulo R.R.; Kaushik-Basu, Neerja; European Journal of Medicinal Chemistry; vol. 93; (2015); p. 51 – 54;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Brief introduction of 1-Bromo-2,4-dimethoxybenzene

The chemical industry reduces the impact on the environment during synthesis 1-Bromo-2,4-dimethoxybenzene. I believe this compound will play a more active role in future production and life.

Electric Literature of 17715-69-4, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 17715-69-4, name is 1-Bromo-2,4-dimethoxybenzene, This compound has unique chemical properties. The synthetic route is as follows.

The chemical industry reduces the impact on the environment during synthesis 1-Bromo-2,4-dimethoxybenzene. I believe this compound will play a more active role in future production and life.