Category: 105404-89-5

Some common heterocyclic compound, 105404-89-5, name is 2,7-Dibromo-3,6-dimethoxynaphthalene, molecular formula is C12H10Br2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of 2,7-Dibromo-3,6-dimethoxynaphthalene

0.125 mol [intermediate 1-1] at room temperature,43.4 g and (4-chloro-2-fluorophenyl) boronic acid 0.301 mol, 52.5 g and Ce2CO3 0.815 mol, 266 g and TTP (tetrakis(triphenylphosphine)palladium(0)) 8 mol% 11.6 g was added with 500 mL of 1,4-dioxane and refluxed. After 4 hours, the reaction was cooled to room temperature, 500 ml of H2O was added, and extracted with EA.After filtration, the obtained solid was recrystallized from EA (ethyl acetate) and Hx (normal hexane) to obtain 0.09 mol of [Intermediate 1-2] and 41.0 g (yield 73%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 105404-89-5, its application will become more common.

Reference:
Patent; LG Chem, Ltd.; Gu Gi-dong; Kim Myeong-gon; Keum Su-jeong; Yoon Jeong-min; (52 pag.)KR2019/111688; (2019); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 105404-89-5, name is 2,7-Dibromo-3,6-dimethoxynaphthalene, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 2,7-Dibromo-3,6-dimethoxynaphthalene

Sodium (0.21 g, 8.6 mmol) was added portionwise to anhydrous methanol (30 mL) stirred under an argon atmosphere. Upon complete dissolution, copper(I) iodide (1.65 g, 8.64 mmol), 3,6-dibromo-2,7-dimethoxynaphthalene (7, 1.50 g, 4.32 mmol) and anhydrous DMF (5 mL), were added to the reaction mixture and brought to reflux for 24 h. Additional copper(I) iodide (0.83 g, 4.32 mmol) and satd sodium methoxide (20 mL) were added to regenerate the catalyst and stirred at reflux for an additional 12 h. The reaction was quenched by the addition of water (10 mL) and extracted with DCM (2*25 mL), washed successively with 10% HCl (2*10 mL), water (2*10 mL), dried (MgSO4) and concentrated in vacuo to afford a crude solid, which was recrystallized from ethanol to afford the title compound (0.75 g, 70%). Mp 255-256 C (lit. 23 mp>200 C). 1H NMR (300 MHz, CDCl3) delta 7.04 (s, 4H), 3.98 (s, 12H); 13C NMR (75 MHz, CDCl3) delta 148.1, 124.1, 55.8; IR (ATR) (cm-1) 3064, 3003, 2964, 2937, 2887, 1669, 1608, 1528, 1510. HRMS (EI+, 70 eV); m/z: [M]+ calcd for C14H16O4 248.1049, found 248.1048.

According to the analysis of related databases, 105404-89-5, the application of this compound in the production field has become more and more popular.

Reference:
Article; Tate, Daniel J.; Abdelbasit, Mohamed; Kilner, Colin A.; Shepherd, Helena J.; Warriner, Stuart L.; Bushby, Richard J.; Tetrahedron; vol. 70; 1; (2014); p. 67 – 74;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Related Products of 105404-89-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 105404-89-5, name is 2,7-Dibromo-3,6-dimethoxynaphthalene belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

0.125 mol, 43.4 g of [Intermediate 1-1] and 0.301 mol of (4-chloro-2-fluorophenyl) boronic acid at room temperature,52.5g and 0.815mol of Ce2CO3, 266g and 11.6g of TTP (tetrakis (triphenylphosphine) palladium (0)) were added together with 500mL of 1,4-dioxane and refluxed.After 4 hours, the reaction was cooled to room temperature, 500 ml of H 2 O was added, and extracted with EA. After filtration, the obtained solid was recrystallized from EA (ethyl acetate) and Hx (normal hexane) to obtain 0.09 mol of [Intermediate 1-2] and 41.0 g (yield 73%).

The synthetic route of 2,7-Dibromo-3,6-dimethoxynaphthalene has been constantly updated, and we look forward to future research findings.

Reference:
Patent; LG Chem, Ltd.; Gu Gi-dong; Yoon Jeong-min; Keum Su-jeong; Kim Myeong-gon; (62 pag.)KR2019/111687; (2019); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthetic Route of 105404-89-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 105404-89-5, name is 2,7-Dibromo-3,6-dimethoxynaphthalene belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: To a solution of 2,7-dibromonaphthalene (300 mg, 1.05 mmol) in1,4-dioxane (10 mL) were added 4-nitrophenylboronic acid (381 mg, 2.28 mmol), Pd(PPh3)4 (28 mg, 0.024 mmol), and aq. Cs2CO3 (2 M, 2 mL), and the reaction mixture was stirred overnight at reflux under Ar. Then, the reaction mixture was diluted with water (30 mL), and the product was extracted with chloroform (100 mL × 3). The organic layer was dried over MgSO4 and concentrated in vacuo. The residue was purified by column chromatography [hexane/chloroform (2:1)] to give 2,7-bis(4-nitrophenyl)naphthalene 3a (326 mg, 0.879 mmol, 84%) as a yellow solid

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,7-Dibromo-3,6-dimethoxynaphthalene, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Hachiya, Sojiro; Asai, Kengo; Konishi, Gen-Ichi; Tetrahedron Letters; vol. 54; 14; (2013); p. 1839 – 1841;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Reference of 105404-89-5, A common heterocyclic compound, 105404-89-5, name is 2,7-Dibromo-3,6-dimethoxynaphthalene, molecular formula is C12H10Br2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Into a 200-mL three-neck flask were put 3.0 g (8.7 mmol) of3,6-dibromo-2,7-dimethoxynaphthalene, 1.2 g (8.7 mmol) of 2-fluorophenylboronic acid, 2.4 g(17 mmol) of potassium carbonate, and 0.13 g (0.43 mmol) of tris(2-methylphenyl)phosphine.5 To this mixture was added 90 mL of toluene. The resulting mixture was degassed by beingstirred while the pressure was reduced. To the mixture was added 19 mg (87 IJ.mol) ofpalladium(II) acetate, and stirring was performed under a nitrogen stream at 110 oc for 7 hours.After the stirring, toluene was added to the mixture, and the resulting mixture wassuction-filtered through Florisil (manufactured by Wako Pure Chemical Industries, Ltd., Catalog10 No. 540-00135), Celite (manufactured by Wako Pure Chemical Industries, Ltd., Catalog No.531-16855), and alumina to give a filtrate. The filtrate was concentrated to give a solid. Thissolid was purified by silica gel column chromatography (as the developing solvent, first, tolueneand hexane in a ratio of 1:2 were used, and then toluene and hexane in a ratio of 1:1 were used)to give 1.1 g of a white solid which was an objective substance in a yield of 34 %. A synthesis15 scheme of Step 1 is shown below

The synthetic route of 105404-89-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SEMICONDUCTOR ENERGY LABORATORY CO., LTD.; TAKEDA, Kyoko; OSAKA, Harue; SEO, Satoshi; SUZUKI, Tsunenori; HASHIMOTO, Naoaki; TAKITA, Yusuke; (225 pag.)WO2018/167612; (2018); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem