Category: 1116-77-4

Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 1116-77-4, Name is 4,4-Diethoxy-N,N-dimethyl-1-butanamine, molecular formula is C10H23NO2, belongs to ethers-buliding-blocks compound, is a common compound. In a patnet, author is Liu, Jing, once mentioned the new application about 1116-77-4, Category: ethers-buliding-blocks.

The production and usage of polybrominated diphenyl ethers (PBDEs) has been gradually phased out and the application of alternative halogenated flame retardants (AHFRs) has been continuously increased. It is essential to understand how the evolving flame retardants industry has affected the occurrence and flux of legacy and alternative flame retardants so that better pollution control measures can be made accordingly. Air, rainwater, inflowing river water, pond water, pond sediment, fish feed, and fish collected from freshwater cultured fish ponds (FWCFPs) within the Pearl River Delta, South China were analyzed for PBDEs and AHFRs. Concentrations of AHFRs in air (range; median: 7.8-870; 210 pg m(-3)), rainwater (0.88-65; 4.8 ng L-1), and sediment (19-120; 54 ng g(-1) dry weight (d.w.)) were one order of magnitude higher than those of PBDEs in air (12-98; 21 pg m(-3)), rainwater (0.18-15; 0.70 ng L-1), and sediment (1.5-9.6, 2.9 ng g(-1) d.w.) (t-test; p < 0.05). Decabromodiphenyl ether and decabromodiphenylethane were the predominant BDE and AHFR components, respectively, agreeing well with the production and usage patterns of flame retardants in China. The average input fluxes of AHFRs to the FWCFPs via dry deposition, wet deposition, net air-water exchange, and feeding (38.6, 20.6, and 2.14, mu g m(-2) yr(-1)) were one order of magnitude higher than those of PBDEs (3.44, 5.17, and -10.1, mu g m(-2) yr(-1)). Elevated occurrence and input fluxes of AHFRs suggested that aquaculture production is potentially facing a new challenge from alternative flame retardants. Atmospheric dry and wet deposition are important input sources of AHFRs to the FWCFPs. Feeding is an important input pathway for both PBDEs and AHFRs. Pollution control measures should be modified to accommodate the evolving flame retardants industry. (C) 2020 Elsevier B.V. All rights reserved. We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 1116-77-4. The above is the message from the blog manager. Category: ethers-buliding-blocks.

Reference:
Ether – Wikipedia,
,Ether | (C2H5)2O – PubChem

In an article, author is Illous, Estelle, once mentioned the application of 1116-77-4, Category: ethers-buliding-blocks, Name is 4,4-Diethoxy-N,N-dimethyl-1-butanamine, molecular formula is C10H23NO2, molecular weight is 189.3, MDL number is MFCD00671479, category is ethers-buliding-blocks. Now introduce a scientific discovery about this category.

Hypothesis: The insertion of polyether spacers between the anionic head and the alkyl chain of ionic surfactants significantly improves their salt-tolerance. The aim of this work is to study whether the petro-based polyethoxy spacer can be replaced by a glyceryl ether group for high salinity applications. Experiments: A series of amphiphilic sodium salts of alkyl glyceryl ether carboxylates are synthesized with different alkyl chain lengths from 4 to 12 and various spacers between the glyceryl and the carboxylate groups. Their aggregation behavior is studied by tensiometry and their amphiphilicities are assessed by the PIT-slope method. The dramatic effect of the methylation of the glyceryl spacer on the salt-tolerance is highlighted, and rationalized by DFT calculations and molecular dynamics. Findings: In contrast to the corresponding sodium soap, n-C6H13-CO2Na, and to the non-methylated counterpart, the sodium salt of 1-pentyl-3-methyl glyceryl ether methylene carboxylate ([5.0.1]-CH2CO2Na) exhibits an excellent salt-tolerance since it remains water-soluble with NaCl or CaCl2 concentrations greater than 20 wt% at 25 degrees C. Amphiphiles with short alkyl chains (Category: ethers-buliding-blocks.

Reference:
Ether – Wikipedia,
,Ether | (C2H5)2O – PubChem

Synthetic Route of 1116-77-4, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1116-77-4, name is 4,4-Diethoxy-N,N-dimethyl-1-butanamine, This compound has unique chemical properties. The synthetic route is as follows.

Example 9 (0448) Synthesis of N-(4-(2-acetoxy-4-methoxybenzoyl)benzyl)-4,4-diethoxy-N,N-dimethylbutan- 1 -aminium bromide (0449) In a N2 purged 20mL weighed glass vial with stir bar is added 1 .5g (0.004mol, 1 .0 eq) of AcO-Bzp-OMe-CH2-Br prepared in Example 7 and 8 mL ethyl acetate to give a clear solution on stirring for 20mins at RT. 2.06 g 4,4-Diethoxy-N,N-dimethyl-1 -butanamine (0450) (NNDMABADEA, from TCI-America) (0.01 mol, 2.5 eq) is slowly added to the reaction solution with stirring. A precipitate is soon formed and gradually thickenes with stirring over 30- 60minutes. The reaction mixture is stirred at RT overnight. The stirring is stopped and the mixture is allowed to stand for an hour. The mixture is filtered through a coarse filter frit at around 850mbar. The precipitate is washed five times with 10ml_ ethyl acetate. The precipitate is transferred into a 10OmL rb flask with about 18ml of Dl Water. The residual organics are removed under reduced pressure to give a clear solution. The solution is filtered through a Whatman1 (1 1 urn) filter paper to give a clear solution with neutral pH, that is frozen and lyophilized to give a off white solid which is confirmed to be N-(4-(2-acetoxy-4- methoxybenzoyl)benzyl)-4,4-diethoxy-N,N-dimethylbutan-1 -aminium bromide and is stored under dry N2 in desiccator.

The chemical industry reduces the impact on the environment during synthesis 4,4-Diethoxy-N,N-dimethyl-1-butanamine. I believe this compound will play a more active role in future production and life.

Reference:
Patent; NOVARTIS AG; CHANG, Frank; DESOUSA, Ryan; HOLLAND, Troy Vernon; LAREDO, Walter R.; (68 pag.)WO2017/93835; (2017); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthetic Route of 1116-77-4, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1116-77-4 as follows.

Example 3Reaction of 4-(1,2,4-triazol-1-yl-methyl)phenyl-hydrazine (IV) with 4-N,N-dimethylamino-butyraldehyde diethyl acetal (X) (Fischer indole synthesis)To the aqueous hydrazine (IV) solution obtained in example 2, conc. sulfuric acid (4.371) was added and the temperature of the reaction mixture was maintained for 2 hours at 65-70 C. After cooling to 20-25 C., 4-N,N-dimethylamino-butyraldehyde diethyl acetal (X) (3.15 kg) was added. The reaction was heated to 70 C. and maintained for 3-4 hours. After completion of the reaction, the reaction mixture was allowed to cool to 15-20 C. To this mixture, 25% aq. ammonia (7.251) was added to adjust the pH to 8.5-9. The solution was extracted with ethyl acetate (4×12.251). A solution of succinic acid (2.45 kg) in water (301) was added to the ethyl acetate extract. The mixture was stirred for 15 minutes. The aqueous layer was separated and washed with ethyl acetate (2×51). The aqueous layer was basified with 20% aq. NaOH to adjust the pH to 8.5-9. The solution was extracted with ethyl acetate (4 x 51). The combined ethyl acetate extracts were concentrated to give rizatriptan free base (VII) as oil (2.8 kg, 75.5% from 4-(1,2,4-triazol-1-yl-methyl)phenylamine (II)). Purity =99.7-99.9% (as measured by HPLC).

According to the analysis of related databases, 1116-77-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Gore, Vinayak G.; Kulkarni, Vikas S.; Wavhal, Sneha R.; US2010/256208; (2010); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1116-77-4, name is 4,4-Diethoxy-N,N-dimethyl-1-butanamine, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of 4,4-Diethoxy-N,N-dimethyl-1-butanamine

Sodium nitrite (16 gm) in water (120 ml) was added slowly for a period of 30 minutes at 0 deg C to a solution of (S)-4-(4-Aminobenzyl)-2-oxazolidinone (40 gm), concentrated hydrochloric acid (46 ml) and water (480 ml) in round bottomed flask, cooled to 0 deg C and stirred for 1 hour. The above diazotized solution was added for a period of 30 minutes at 0 deg C to sodium sulfite (78.3 gm) in water (200 ml) in another round bottomed flask, cooled to 0 deg C, slowly allowed to room temperature, heated to 55 deg C and stirred for 15 minutes at 60 deg C. Added concentrated hydrochloric acid (80 ml) to the reaction mass, stirred for 16 hours at 60 deg C, nitrogen gas was applied and heated to 90 deg C. Water (80 ml) was added to the reaction mass for 15 minutes at 90 deg C, added 4-(dimethylamino)-butyraldehyde diethylacetal for a period of 40 minutes, heated to reflux, stirred for 3 hours at reflux, cooled to 25 – 30 deg C and the pH was adjusted to 7 by adding sodium hydroxide solution(30%, 230 ml). Extracted with ethyl acetate (7 X 200 ml), adjusted the pH of the aqueous layer to 10 by adding sodium hydroxide solution (30%, 100 ml), heated to 50 deg C and again extracted with ethyl acetate (8 X 200 ml) at 50 deg C. Both the organic layers were combined, dried with sodium sulfate, given carbon treatment and the solvent was distilled off completely under vacuum at 50 – 55 deg C, ethyl acetate (80 ml) was added to the reaction mass at 25 deg C, stirred for 1 hour and cooled to 10 deg C. Stirred for 30 minutes at 10 deg C, filtered the material and washed with chilled ethylacetate(20 ml) under nitrogen atmosphere and dried at 45 -50 deg C to yield 40 gm of (4S)-4-[[3-[2-(Dimethylamino)ethyl]~ 1 H-indol-5-yl]methyl]-2-oxazolidinone.(4S)-4-[[3-[2-(Dimethylamino)ethyl]-1H-indol-5-yl]methyl]-2-oxazolidinone (40 gm, Zolmitriptan) was dissolved in isopropanol (200 ml) at 25 deg C, heated to reflux, stirred for 40 minutes at reflux and slowly allowed to cool to 0 deg C. Stirred the reaction mass for 1 hour at 0 deg C, filtered the compound, washed with chilled isopropanol(40 ml) and dried at 40 – 45 deg C under vacuum to yield (4S)-4-[[3-[2-(Dimethylamino)ethyl]-1H-indol-5-yl]methyl]-2-oxazolidinone isopropanol solvate (32 gm, Zolmitriptan isopropanol solvate; HPLC purity. 99.32%). Zolmitriptan isopropanol solvate obtained above (32 gm) was dissolved in isopropyl acetate (2250 ml) at 25 deg C. Then the contents were heated to reflux and maintained for 30 minutes to form clear solution. The solution was cooled to 25 deg C during a period of 1 hour. The separated solid was filtered, washed with isopropyl acetate (160 ml) to obtain 32 gm of zolmitriptan isopropyl acetate solvate (HPLC purity: 99.8%).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1116-77-4.

Some common heterocyclic compound, 1116-77-4, name is 4,4-Diethoxy-N,N-dimethyl-1-butanamine, molecular formula is C10H23NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Formula: C10H23NO2

Example 3: Reaction of 4-(1.2.4-triazol-l-yl-methyl)phenyl-hydrazine (IV) with 4-N.N- dimethylamino-butyraldehyde diethyl acetal (X) (Fischer indole synthesis); To the aqueous hydrazine (IV) solution obtained in example 2, cone, sulfuric acid (4.371) was added and the temperature of the reaction mixture was maintained for 2 hours at 65- 700C. After cooling to 20-250C, 4-N,N-dimethylamino-butyraldehyde diethyl acetal (X) (3.15kg) was added. The reaction was heated to 700C and maintained for 3-4 hours. After completion of the reaction, the reaction mixture was allowed to cool to 15-200C. To this mixture, 25% aq. ammonia (7.251) was added to adjust the pH to 8.5-9. The solution was extracted with ethyl acetate (4 x 12.251). A solution of succinic acid (2.45kg) in water (301) was added to the ethyl acetate extract. The mixture was stirred for 15 minutes. The aqueous layer was separated and washed with ethyl acetate (2 x 51). The aqueous layer was basified with 20% aq. NaOH to adjust the pH to 8.5-9. The solution was extracted with ethyl acetate (4 x 51). The combined ethyl acetate extracts were concentrated to give rizatriptan free base (VII) as oil (2.8kg, 75.5% from 4-(l,2,4-triazol-l-yl- methyl)phenylamine (IT)). Purity = 99.7-99.9% (as measured by HPLC).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1116-77-4, its application will become more common.

Reference of 1116-77-4, These common heterocyclic compound, 1116-77-4, name is 4,4-Diethoxy-N,N-dimethyl-1-butanamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example-2: Preparation of Rizatriptan Benzoate:- l-(4-Hydrazinophenyl)methyl-l52:,4-triazole hydrochloride (7.0 kg.) in Cone. HCl (35.0 It.) is stirred for 30 min at 20-250C, to that water (140.0 It.) is added and stirred for another 30min at 20-250C. 4-(Dimethylamino) butanal diethylacetal (7.10 kg.) is added slowly at 20-250C and stirred for 60 min. The reaction mixture is hated to 70-750C and maintained for 60 min. After completion of reaction, cooled the mass to 3O0C, adjusted the pH to 6.0-6.5 and extracted with methylene chloride (2 x 35 It.). Aq.layer is separated and adjusted the pH to 10-11 and extracted with ethyl acetate (3 x 55 It.). Ethyl acetate is removed under vacuum and the residue is chromatographed on silica gel (55 kg.) and eluted with ethyl acetate (25 It.) followed by methanol (30 It.) to give Rizatriptan as residue. The obtained residue is dissolved in ethanol (15 It.) and pH is adjusted to 6.0- 6.5 with benzoic acid (1.8 kg.) in ethanol (3.5 It ) at 30-350C. The reaction mass is cooled to O0C and stirred for lhr. The product is centrifuged and washed with ethanol ( 3 It) to yield Rizatriptan benzoate (3.0 kg.) with purity >99.0%.

The synthetic route of 1116-77-4 has been constantly updated, and we look forward to future research findings.

Chemistry, like all the natural sciences, begins with the direct observation of nature¡ª in this case, of matter.1116-77-4, Name is 4,4-Diethoxy-N,N-dimethyl-1-butanamine, SMILES is CN(C)CCCC(OCC)OCC, belongs to ethers-buliding-blocks compound. In a document, author is Sandvoss, Alexander, introduce the new discover, Recommanded Product: 1116-77-4.

Recent Advances in Enantioselective Desymmetrizations of Prochiral Oxetanes

Strain relief of oxetanes offers a plethora of opportunities for the synthesis of chiral alcohols and ethers. In this context, enantioselective desymmetrization has been identified as a powerful tool to construct molecular complexity and this has led to the development of elegant strategies on the basis of transition metal, Lewis acid, and Bronsted acid catalysis. This review highlights recent examples that harness the inherent reactivity of prochiral oxetanes and offers an outlook on the immense possibilities for synthetic application.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 1116-77-4 is helpful to your research. Recommanded Product: 1116-77-4.

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 1116-77-4, Name is 4,4-Diethoxy-N,N-dimethyl-1-butanamine, SMILES is CN(C)CCCC(OCC)OCC, in an article , author is Jin, Lei, once mentioned of 1116-77-4, Recommanded Product: 1116-77-4.

Highly Proton Conductive Sulfonyl Imide Based Polymer Blended from Poly(arylene ether sulfone) and Parmax-1200 for Fuel Cells

Thermally and chemically stable, sulfonyl imide-based polymer blends have been prepared from sulfonimide poly(arylene ether sulfone) (SI-PAES) and sulfonimide Parmax-1200 (SI-Parmax-1200) using the solvent casting method. Initially, sulfonimide poly(arylene ether sulfone) (SI-PAES) polymers have typically been synthesized via direct polymerization of bis(4-chlorophenyl) sulfonyl imide (SI-DCDPS) and bis(4-fluorophenyl) sulfone (DFDPS) with bisphenol A (BPA). Subsequently, SI-Parmax-1200 has been synthesized via post-modification of the existing Parmax-1200 polymer followed by sulfonation and imidization. The SI-PAES/SI-Parmax-1200 blend membranes show high ion exchange capacity ranging from 1.65 to 1.97 meq/g, water uptake ranging from 22.8 to 65.4% and proton conductivity from 25,9 to 78.5 mS/cm. Markedly, the SI-PAES-40/SI-Parmax-1200 membrane (blended-40) exhibits the highest proton conductivity (78.5 mS/cm), which is almost similar to Nafion 117 (R) (84.73 mS/cm). The thermogravimetric analysis (TGA) and Fenton’s test confirm the excellent thermal and chemical stability of the synthetic polymer blends. Furthermore, the scanning electron microscopy (SEM) study shows a distinct phase separation at the hydrophobic/hydrophilic segments, which facilitate proton conduction throughout the ionic channel of the blend polymers. Therefore, the synthetic polymer blends represent an alternative to Nafion 117 (R) as proton exchangers for fuel cells.

Interested yet? Read on for other articles about 1116-77-4, you can contact me at any time and look forward to more communication. Recommanded Product: 1116-77-4.

In an article, author is Camp, Andrew M., once mentioned the application of 1116-77-4, Name is 4,4-Diethoxy-N,N-dimethyl-1-butanamine, molecular formula is C10H23NO2, molecular weight is 189.3, MDL number is MFCD00671479, category is ethers-buliding-blocks. Now introduce a scientific discovery about this category, Formula: C10H23NO2.

Selecting Double Bond Positions with a Single Cation-Responsive Iridium Olefin Isomerization Catalyst

The catalytic transposition of double bonds holds promise as an ideal route to alkenes of value as fragrances, commodity chemicals, and pharmaceuticals; yet, selective access to specific isomers is a challenge, normally requiring independent development of different catalysts for different products. In this work, a single cation-responsive iridium catalyst selectively produces either of two different internal alkene isomers. In the absence of salts, a single positional isomerization of 1-butene derivatives furnishes 2-alkenes with exceptional regioselectivity and stereoselectivity. The same catalyst, in the presence of Na+, mediates two positional isomerizations to produce 3-alkenes. The synthesis of new iridium pincer-crown ether catalysts based on an aza-18-crown-6 ether proved instrumental in achieving cation-controlled selectivity. Experimental and computational studies guided the development of a mechanistic model that explains the observed selectivity for various functionalized 1-butenes, providing insight into strategies for catalyst development based on noncovalent modifications.

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