Category: 1116-77-4

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 1116-77-4, Name is 4,4-Diethoxy-N,N-dimethyl-1-butanamine, SMILES is CN(C)CCCC(OCC)OCC, belongs to ethers-buliding-blocks compound. In a document, author is Shaw, Montgomery T., introduce the new discover, Computed Properties of C10H23NO2.

On finding the zero-shear-rate viscosity of polymer melts

A significant fraction of the experimental works on the rheology of polymer melts include an attempt to find the zero-shear-rate viscosity eta(0). This is done for good reasons, because eta(0) is a limiting property that depends only on thermodynamic variables and, importantly, the molecular and supermolecular structure of the melt. As with all limiting properties, eta(0) is impossible to measure directly. Fortunately with many melts, it can be estimated from viscosity measurements at very low shear rates or frequencies, but still remains one of those properties that becomes in the limit very prone to error. The common approach is to use a set of frequency- or shear-rate-dependent data and extrapolate to find eta(0). As with any extrapolation, the major question is the function used for the extrapolation. This question is addressed in some detail in this article. The question of which function to use was discarded in favor of using a large sample of 20 equations of many functional forms. This sample of randomly chosen equations was used to generate a set of eta(0) values, and the statistics of this distribution were examined, in the usual fashion, by description with an analytical probability density function that gives a high probability of being a likely generator of the data. In addition, a weighted average was proposed, where the weighting factor takes into account the quality of the fit. For testing these ideas, the room temperature melts of poly(vinyl isobutyl ether), poly(isobutylene), and poly(dimethyl siloxane) were used. The eta(0) of the latter was reachable; for the other resins, a falling ball technique was attempted.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 1116-77-4 is helpful to your research. Computed Properties of C10H23NO2.

In an article, author is Illous, Estelle, once mentioned the application of 1116-77-4, Name: 4,4-Diethoxy-N,N-dimethyl-1-butanamine, Name is 4,4-Diethoxy-N,N-dimethyl-1-butanamine, molecular formula is C10H23NO2, molecular weight is 189.3, MDL number is MFCD00671479, category is ethers-buliding-blocks. Now introduce a scientific discovery about this category.

Salt-tolerance of alkyl-glyceryl ether carboxylates hydrotropes and surfactants. Dramatic effect of the methylation of the glyceryl spacer

Hypothesis: The insertion of polyether spacers between the anionic head and the alkyl chain of ionic surfactants significantly improves their salt-tolerance. The aim of this work is to study whether the petro-based polyethoxy spacer can be replaced by a glyceryl ether group for high salinity applications. Experiments: A series of amphiphilic sodium salts of alkyl glyceryl ether carboxylates are synthesized with different alkyl chain lengths from 4 to 12 and various spacers between the glyceryl and the carboxylate groups. Their aggregation behavior is studied by tensiometry and their amphiphilicities are assessed by the PIT-slope method. The dramatic effect of the methylation of the glyceryl spacer on the salt-tolerance is highlighted, and rationalized by DFT calculations and molecular dynamics. Findings: In contrast to the corresponding sodium soap, n-C6H13-CO2Na, and to the non-methylated counterpart, the sodium salt of 1-pentyl-3-methyl glyceryl ether methylene carboxylate ([5.0.1]-CH2CO2Na) exhibits an excellent salt-tolerance since it remains water-soluble with NaCl or CaCl2 concentrations greater than 20 wt% at 25 degrees C. Amphiphiles with short alkyl chains (Name: 4,4-Diethoxy-N,N-dimethyl-1-butanamine.

Reference of 1116-77-4, These common heterocyclic compound, 1116-77-4, name is 4,4-Diethoxy-N,N-dimethyl-1-butanamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

(ii) Preparation of crude rizatriptan benzoate; Into a clean IOOL glass reactor were charged water (20L) cone. HCl (8.5L), and l-(4- aminophenylmethyl)-l,2,4-triazole (5.0Kg). The reaction mass was stirred for 20-30min at 25-30 C and cooled to 0-5 C. Aqueous sodium nitrite (2.1Kg in 3.0Lof water) was added to the reaction mass below 5C over a period of 2hr. The reaction mass was maintained below 50C for lhr.Into a clean, 200L glass reactor were charged water (30 L) and sodium sulfite (9.0 Kg) under nitrogen atmosphere at 25-30 C. The resulting solution was cooled to below 10 C. Above diazonium salt solution was added to the reaction mass in 20-30 min period keeping the temperature below 10 C. The reaction mass was slowly heated to 65-7O0C over a period of 2.5-3. Ohr. After maintaining at this temperature for 2hr sulfuric acid EPO (7.2L) was added to the reaction mixture and continued the maintenance at same temperature for 2.0-2.5 hr. The reaction mass was cooled to reach 20-25 0C.4-Dimethylaminobutyraldehyde diethyl acetal (7.8 kg) was added to the reaction mass in 30-45min keeping the temperature at 25-30 C. The reaction mass was maintained at this temperature for 4-5hr. TLC of the reaction mass indicated the absence of starting material. The reaction mass was heated to 35-400C and maintained for lhr. Temperature of the reaction mass was further raised to 60-65C and maintained for 3.5hr. The reaction mass was cooled to 20-30C and adjusted the pH of reaction mass to 6.5-7.0 with ammonia solution. Ethyl acetate (15L) was added to the reaction mass and stirred for 15- 20min and separated the organic layer. Aqueous layer pH was adjusted to 8.5-9.0 with ammonia solution. Aqueous layer was extracted with ethyl acetate (3 x 35L). Combined ethyl acetate layer was treated with activated carbon (lkg) and distilled of solvent under reduced pressure to get 4.7kg crude rizatriptan base as oil.The above crude rizatriptan base was dissolved in 18L of acetone at 25-30 0C. Benzoic acid (2.1kg) was added to the reaction mass at 25-30 C. After stirring for 45-60min at 25-30 C the reaction mixture was cooled to below 0 C and maintained for 10-12hr. The reaction mass was allowed to reach 20-25 0C and maintained for 2.5hr- before filtration. The wet cake was washed with 3.5L of acetone. Drying at 50-60 C gave 3kg of rizatriptan benzoate.; Example 4; Preparation of rizatriptan benzoate; (i) Preparation of crude rizatriptan benzoate:; Into a clean IOOL glass reactor were charged water (30L)5 cone. HCl (15kg), and l-(4- aminophenylmethyl)-l,2,4-triazole (7.5Kg). The reaction mass was stirred for 20-30min at 25-30 0C and cooled to below 0 C. Aqueous sodium nitrite (3.2Kg in 5Lof water) was added to the reaction mass below 5C over a period of 2hr. The reaction mass was maintained below 5C for lhr.Into a clean, 200L glass reactor were charged water (45 L) and sodium sulfite (13.5 Kg) under nitrogen atmosphere at 25-30 C. The resulting solution was cooled to below 10 0C. The above prepared diazonium salt solution was added to the reaction mass in 20-30 min period keeping the temperature below 10 C. The reaction mass was slowly heated to 65-70C over a period of 2.5-3.Ohr. After maintaining at this temperature for 2hr sulfuric acid (19.8kg) was added to the reaction mixture and continued the maintenance at same temperature for 2.0-2.5 hr. The reaction mass was cooled to reach 20-25 0C.4-Dimethylaminobutyraldehyde diethyl acetal (11.7 kg) was added to the reaction mass in 30-45min keeping the temperature at 25-30 0C. The reaction mass was maintained at this temperature for 4-5hr. TLC of the reaction mass indicated the absence of starting material. The reaction mass was heated to 35-40C and maintained for lhr. Temperature of the reaction mass was further raised to 60-65C and maintained for 3.5hr. The reaction mass was cooled to 20-30C and adjusted the pH of reaction mass to 6.5-7.0 with ammonia solution. Ethyl acetate (15L) was added to the reaction mass and stirred for 15-20min and separated the organic layer. Aqueous layer pH was adjusted to 8.8-9.2 with ammonia solution. Aqueous layer was extracted with ethyl acetate (3 x 45L). Combined ethyl acetate layer was treated with activated carbon (1.5kg) and distilled of solvent under reduced pressure to get 7.5kg of crude rizatriptan base as oil. EPO The above crude rizatriptan base was dissolved in 3OL of acetone at 25-30 0C. Benzoic acid (3.5kg) was added to the reaction mass at 25-30 C. After stirring for 45-60min at 25-30 C the reaction mixture was cooled to below 0 C and maintained for 10-12hr. The reaction mass was allowed to reach 20-25 C and maintained for 2.5hr before filtration. The wet cake was washed with 5L of acetone. Drying at 50-60 0C gave 4.5kg of rizatriptan benzoate.

Statistics shows that 4,4-Diethoxy-N,N-dimethyl-1-butanamine is playing an increasingly important role. we look forward to future research findings about 1116-77-4.

Reference:
Patent; NATCO PHARMA LIMITED; PULLA REDDY, Muddasani; SATYASRINIVAS, Hanumara; RADHARANI, Kagitha; VENKAIAH CHOWDARY, Nannapaneni; WO2006/137083; (2006); A1;,
Ether – Wikipedia,
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