Analyzing the synthesis route of 3-Ethynylanisole

According to the analysis of related databases, 768-70-7, the application of this compound in the production field has become more and more popular.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 768-70-7, name is 3-Ethynylanisole, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 768-70-7

A mixture of methyl 4-hydroxy-3-iodobenzoate (0.14 g, 0.50 mmol), 3-ethynylanisole (0.19 mL, 1.50 mmol), bis(triphenylphosphine)palladium(II) chloride (0.035 g, 0.050 mmol), copper(I) iodide (9.5 mg, 0.050 mmol) and 1,1,3,3-tetramethylguanidine (0.63 mL, 5.00 mmol) in N,lambda/-dimethylformamide (5 mL) under an atmosphere of argon was heated at 70 0C for 3 days. The reaction mixture was diluted with ethyl acetate and washed with water. The organic phase was dried over magnesium sulfate and the solvent was evaporated. Purification by column chromatography, using heptane:ethyl acetate (9:1) as the eluent, gave 0.13 g (91% yield) of the title compound.1H NMR (CDCl3) delta ppm 8.35 (dd, 1 H) 8.04 (dd, 1 H) 7.57 (d, 1 H) 7.49 (ddd, 1 H) 7.37 – 7.45 (m, 2 H) 7.10 (d, 1 H) 6.96 (ddd, 1 H) 3.98 (s, 3 H) 3.93 (s, 3 H); MS (EI) m/z 282 [M]+.

According to the analysis of related databases, 768-70-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ASTRAZENECA AB; WO2009/64251; (2009); A1;,
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Extracurricular laboratory: Synthetic route of 3-Ethynylanisole

According to the analysis of related databases, 768-70-7, the application of this compound in the production field has become more and more popular.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 768-70-7 as follows. Application In Synthesis of 3-Ethynylanisole

1.0 mmol of m-methoxyphenylacetylene, 1.5 mol of sodium azide, 1.2 mmol of benzyl bromide, and 0.1 mmol of cuprous iodide were added to 4002.0 mL of polyethylene glycol, and the reaction was stirred at room temperature for 35 minutes, and the reaction was completed. The product was treated by column chromatography V petroleum ether: V ethyl acetate = 3: 1 to obtain 1-benzyl-4- (3-methoxy) phenyl1,2,3-triazole. The product was a white solid. Yield: 92%.

According to the analysis of related databases, 768-70-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Leshan Normal University; Zeng Hongyao; Xia Liewen; Wang Yinghong; (13 pag.)CN110498772; (2019); A;,
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Brief introduction of 768-70-7

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Ethynylanisole, other downstream synthetic routes, hurry up and to see.

Synthetic Route of 768-70-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 768-70-7, name is 3-Ethynylanisole belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Step B:; In nitrogen atmosphere, the above ester (115 mg, 0.25 mmol) and 1-ethynyl-3- methoxybenzene (97 muL, 0.75 mmol) were dissolved in anhydrous tetrahydrofuran (4 mL). 0.15 M Solution of tri-tert-butylphosphine in cyclohexane (0.2 mL, 0.03 mmol) was added via syringe. Copper()) iodide (1.9 mg, 0.01 mmol), dichloro(bisbenzonitrile)palladium (5.7 mg, 0.015 mmol) and diisopropylamine (84 muL, 0.60 mmol) were added. The traces of the air were removed and the mixture was stirred under nitrogen at ambient temperature overnight. The mixture was diluted with ethyl acetate (10 mL) and filtered through a short path of silica gel. The filtrate was concentrated and purified by column chromatography (silica gel Fluka 60, hexanes/ethyl acetate 7:3 -1: 1 – 3: 7) yielding ethyl [4-[3,5-bis-(3-methoxyphenylethynyl)- phenylsulfanyl]-2-methylphenoxy]acetate. Yield: 87 mg (62 %). RF (Si02, hexanes/ethyl acetate 9:1) 0.25. , ¹H NMR spectrum (200 MHz, CDCI3, No.H) : 7.48 (t, J=1.4 Hz, 1 H) ; 7.35-7.25 (m, 6 H); 7.15- 7.01 (m, 4 H) ; 6.95-6.85 (m, 2 H) ; 6.72 (d, J=8.5 Hz, 1 H) ; 4.67 (s, 2 H) ; 4.27 (q, J=7.1 Hz, 2 H) ; 2.30 (s, 3 H); 1.29 (t, J=7.1 Hz, 3 H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Ethynylanisole, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; NOVO NORDISK A/S; WO2005/105726; (2005); A1;,
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Analyzing the synthesis route of 3-Ethynylanisole

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Ethynylanisole, its application will become more common.

Related Products of 768-70-7,Some common heterocyclic compound, 768-70-7, name is 3-Ethynylanisole, molecular formula is C9H8O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A 1.6 M solution of n-BuLi in hexanes (1.1equiv) was added to a solution of the corresponding terminal alkyne (1.0 equiv) in THF (5 mL per mmol) at -40 C. After stirring for 30min, acetoxy-benziodoxole 6 (1.1equiv) was added in one portion. The mixture was kept at -40 C for 10 min and then allowed to reach room temperature while stirring for 2 h. Then, the reaction mixture was quenched with a saturated solution of NaHCO3 and extracted three times with dichloromethane. After the evaporation of the solvent, the crude product was purified by column chromatography (silica gel; heptanes/EtOAc) to afford the alkyne dimer 7, as well as 13-24, in the reported yields

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Ethynylanisole, its application will become more common.

Reference:
Article; Schoergenhumer, Johannes; Waser, Mario; Tetrahedron Letters; vol. 57; 15; (2016); p. 1678 – 1680;,
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Extended knowledge of C9H8O

According to the analysis of related databases, 768-70-7, the application of this compound in the production field has become more and more popular.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 768-70-7 as follows. category: ethers-buliding-blocks

Weigh 10 mg of the above catalyst, 0.5 mmol of compound 1, and 1 mmol of K3PO4 solids into a 10 ml Shrek tube.Seal the nozzle with a rubber stopper and protect it with vacuum argon.Using a microsampler, 1 mmol of Compound 2 and 5 ml of DMF solvent were injected into the reaction system through a rubber stopper.Place the reaction tube in an oil bath at 160 C.After 5h of reaction, the catalyst was filtered off,Obtain a uniform reaction solution, wash with water to remove DMF,Then, it is dried and separated by column chromatography to obtain 2- (3-methoxyphenyl) benzofuran of the following structural formula 5,NMR yield was 91%.

According to the analysis of related databases, 768-70-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Chinese Academy Of Sciences Tsingtao Biological Energies And Process Institute; Yang Yong; Ji Guijie; Duan Yanan; Zhang Shaochun; (10 pag.)CN110386909; (2019); A;,
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Extended knowledge of C9H8O

According to the analysis of related databases, 768-70-7, the application of this compound in the production field has become more and more popular.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 768-70-7 as follows. category: ethers-buliding-blocks

Weigh 10 mg of the above catalyst, 0.5 mmol of compound 1, and 1 mmol of K3PO4 solids into a 10 ml Shrek tube.Seal the nozzle with a rubber stopper and protect it with vacuum argon.Using a microsampler, 1 mmol of Compound 2 and 5 ml of DMF solvent were injected into the reaction system through a rubber stopper.Place the reaction tube in an oil bath at 160 C.After 5h of reaction, the catalyst was filtered off,Obtain a uniform reaction solution, wash with water to remove DMF,Then, it is dried and separated by column chromatography to obtain 2- (3-methoxyphenyl) benzofuran of the following structural formula 5,NMR yield was 91%.

According to the analysis of related databases, 768-70-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Chinese Academy Of Sciences Tsingtao Biological Energies And Process Institute; Yang Yong; Ji Guijie; Duan Yanan; Zhang Shaochun; (10 pag.)CN110386909; (2019); A;,
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Application of C9H8O

According to the analysis of related databases, 768-70-7, the application of this compound in the production field has become more and more popular.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 768-70-7, name is 3-Ethynylanisole, This compound has unique chemical properties. The synthetic route is as follows., category: ethers-buliding-blocks

General procedure: In an oven-dried Schlenk tube 2-iodophenol 6 (0.5 mmol), terminalalkyne 4 (0.5 mmol), PdO/MWCNT (5 mol%), K2CO3(1 mmol) and solvent (DMSO) (1.0 mL) were added. Theresulting reaction mixture was stirred at 120 C for 24 h. Theprogress of the reaction was monitored by TLC. After completionof reaction, the reaction mixture was allowed to coolto room temperature, then diluted with (10 mL) ethyl acetateand NH4Cl (10 mL) was added fallowed by extraction withethyl acetate. The organic layers were dried (Na2SO4) andconcentrated in vacuum. Purification of the residue by silicagel column chromatography using petroleum ether/ethylacetate as the eluent furnished the benzofuran 7.

According to the analysis of related databases, 768-70-7, the application of this compound in the production field has become more and more popular.

Reference:
Article; Lakshminarayana, Bhairi; Mahendar, Lodi; Chakraborty, Jhonti; Satyanarayana, Gedu; Subrahmanyam, Ch; Journal of Chemical Sciences; vol. 130; 5; (2018);,
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Extended knowledge of 768-70-7

The synthetic route of 3-Ethynylanisole has been constantly updated, and we look forward to future research findings.

Synthetic Route of 768-70-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 768-70-7, name is 3-Ethynylanisole belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: To a mixture of alpha-azidoamide 16aa (34 mg, 0.20 mmol) and phenylacetylene (9a; 24 L,0.20 mmol) in t-BuOH/H2O (2 mL, 1:1) were added 0.5 M CuSO4 (0.020 mL, 0.010 mmol) and 1.0 M sodium ascorbate (0.020 mL, 0.020 mmol). The reaction mixture was stirred at room temperature for 1 day, and then the resulting reaction mixture was filtered. The separated solid was washed with H2O and hexanes, and triturated with hexane/EtOAc (10:1) to give the 1-morpholino-2-(4-phenyl-1H-1,2,3-triazol-1-yl)ethanone (2aaa; 52 mg, 96%) as a white solid

The synthetic route of 3-Ethynylanisole has been constantly updated, and we look forward to future research findings.

Reference:
Article; Lee, Doohyun; Kim, Daehun; Lee, Seungyeon; Kim, Taegeum; Kim, Joobin; Kim, Sohee; Liu, Kwang-Hyeon; Lee, Sangkyu; Bae, Jong-Sup; Song, Kyung-Sik; Cho, Chang-Woo; Son, Youn Kyung; Baek, Dong Jae; Lee, Taeho; Molecules; vol. 20; 11; (2015); p. 19984 – 20013;,
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New downstream synthetic route of 768-70-7

The synthetic route of 768-70-7 has been constantly updated, and we look forward to future research findings.

Reference of 768-70-7, A common heterocyclic compound, 768-70-7, name is 3-Ethynylanisole, molecular formula is C9H8O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: Preparation of Copper Acetylides; Procedure 1To a solution of CuI (3.8 g, 20.0 mmol) in a mixture of NH4OH(28% NH3 solution, 50 mL) and EtOH (30 mL) was added the alkyne1 (10.0 mmol) dropwise. The deep blue reaction mixture wasstirred overnight at r.t. under argon and the yellow precipitate wascollected by filtration and successively washed with NH4OH (10%NH3 solution, 3 × 50 mL), H2O (3 × 50 mL), EtOH (3 × 50 mL), andEt2O (3 × 50 mL). The bright yellow solid was then dried under highvacuum overnight to afford the desired polymeric copper acetylide2, which was used without further purification.

The synthetic route of 768-70-7 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Theunissen, Cedric; Lecomte, Morgan; Jouvin, Kevin; Laouiti, Anouar; Guissart, Celine; Heimburger, Jeremy; Loire, Estelle; Evano, Gwilherm; Synthesis; vol. 46; 9; (2014); p. 1157 – 1166;,
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Introduction of a new synthetic route about C9H8O

The synthetic route of 768-70-7 has been constantly updated, and we look forward to future research findings.

Reference of 768-70-7, A common heterocyclic compound, 768-70-7, name is 3-Ethynylanisole, molecular formula is C9H8O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: General produce: o-iodophenol (0.5 mmol), alkyne (1.0 mmol) andbase (1.0 mmol) were added into a 10 mL dry Schlenk tube under Ar,then anhydrous DMF (5 mL) was injected into the mixture using syringe.Then the solution stirred at preheated oil bath (160 C). The reactionwas monitored by TLC and GC.The mixture was cooled down toroom temperature after full conversion, then diluted with dichloromethaneand washed with water three times. The organic layerwas separated and washed with brine followed by drying with anhydrousNa2SO4. The filtrate was concentrated in vacuo to afford thecrude product, which was purified by flash column chromatography onsilica gel (petroleum ether).

The synthetic route of 768-70-7 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Ji, Guijie; Duan, Yanan; Zhang, Shaochun; Yang, Yong; Catalysis Today; (2019); p. 101 – 108;,
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