In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 768-70-7 as follows. category: ethers-buliding-blocks
Weigh 10 mg of the above catalyst, 0.5 mmol of compound 1, and 1 mmol of K3PO4 solids into a 10 ml Shrek tube.Seal the nozzle with a rubber stopper and protect it with vacuum argon.Using a microsampler, 1 mmol of Compound 2 and 5 ml of DMF solvent were injected into the reaction system through a rubber stopper.Place the reaction tube in an oil bath at 160 C.After 5h of reaction, the catalyst was filtered off,Obtain a uniform reaction solution, wash with water to remove DMF,Then, it is dried and separated by column chromatography to obtain 2- (3-methoxyphenyl) benzofuran of the following structural formula 5,NMR yield was 91%.
According to the analysis of related databases, 768-70-7, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Chinese Academy Of Sciences Tsingtao Biological Energies And Process Institute; Yang Yong; Ji Guijie; Duan Yanan; Zhang Shaochun; (10 pag.)CN110386909; (2019); A;,
Ether – Wikipedia,
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