14-Sep-21 News Some tips on 910251-11-5

The synthetic route of 910251-11-5 has been constantly updated, and we look forward to future research findings.

910251-11-5, name is Potassium trifluoro(methoxymethyl)borate, belongs to ethers-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. COA of Formula: C2H5BF3KO

Under an argon atmosphere a mixture of 70 mg of tert-butyl 10-bromo-8-cyclopropyl-3,4,7,8-tetrahydro-1H-[1,4]diazepino[6,7,1-ij]quinoline-2(6H)-carboxylate (0.172 mmol, 1.00 eq) from step 8.2, 52.2 mg of potassium trifluoro (2-methoxymethyl)borate (0.344 mmol, 2.00 eq), 168 mg of cesium carbonate (0.516 mmol, 3.00 eq), 1.43 mg of Pd(OAc)2 (0.006 mmol, 0.04 eq) and 5.73 mg of X-Phos (0.012 mmol, 0.07 eq) in degassed dioxane (4 mL) and water (0.5 mL) was heated in a microwave at 130 C. for 40 h. Then the mixture was extracted with DCM and the organic phase was washed with water and dried over MgSO4, filtrated and solvent was evaporated to yield the title compound. ESI-MS: m/z (%): 373.30 (100, [M+H]+).

The synthetic route of 910251-11-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; AbbVie Deutschland GmbH & Co. KG; BACKFISCH, Gisela; BAKKER, Margaretha Henrica Maria; BLAICH, Guenter; BRAJE, Wilfried; DRESCHER, Karla; ERHARD, Thomas; HAUPT, Andreas; KOOLMAN, Hannes; LAKICS, Viktor; LINSENMEIER, Anna; MACK, Helmut; PETER, Raimund; RELO, Ana Lucia; US2015/259343; (2015); A1;,
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9/1/2021 News The important role of 910251-11-5

The chemical industry reduces the impact on the environment during synthesis Potassium trifluoro(methoxymethyl)borate. I believe this compound will play a more active role in future production and life.

Electric Literature of 910251-11-5, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 910251-11-5, name is Potassium trifluoro(methoxymethyl)borate, This compound has unique chemical properties. The synthetic route is as follows.

Potassium methoxymethyltrifluoroborate (18 mg, 0.12 mmol), l-(6- bromospiro[chroman-2, 1 ‘-cyclobutan] -4-yl)-3 -( 1 ‘,4-dimethyl- 1 -phenyl- 1 H, 1 -[3 ,4′-bipyrazol] – 5-yl)urea (Example 34; 33 mg, 0.060 mmol), dichloro[l,l’-bis(diphenylphosphino)- ferrocene]palladium (II) dichloromethane adduct (9.8 mg, 0.012 mmol) and Cs2C03 (98 mg, 0.30 mmol) were combined in dioxane (2 mL) and water (0.5 mL) and degassed by bubbling N2 through the mixture for 10 minutes, The reaction was then sealed in a glass tube and heated at 100 C for 3 hours. The reaction was cooled, poured into brine (10 mL) and extracted with EtOAc (2 x 10 mL). The combined organic extracts were concentrated and purified by reverse- phase column chromatography using 0-70% acetonitrile/H20 as the eluent to provide the title compounds: l-(l’,4-dimethyl-l-phenyl-lH,rH-[3,4′-bipyrazol]-5-yl)-3-(6- (methoxymethyl)spiro[chroman-2, -cyclobutan]-4-yl)urea [second peak, 2.8 mg, 0.0055 mmol, 9.1% yield, MS (apci) m/z = 513.3 (M+H)] and l-(l’,4-dimethyl-l-phenyl-lH,l’H-[3,4′- bipyrazol]-5-yl)-3-(spiro[chroman-2, -cyclobutan]-4-yl)urea [first peak, 2.50 mg, 0.0053 mmol, 8.8% yield, MS (apci) m/z = 469.2 (M+H)].

The chemical industry reduces the impact on the environment during synthesis Potassium trifluoro(methoxymethyl)borate. I believe this compound will play a more active role in future production and life.

Reference:
Patent; ARRAY BIOPHARMA INC.; ALLEN, Shelley; ANDREWS, Steven, Wade; BLAKE, James, F.; BRANDHUBER, Barbara, J.; HAAS, Julia; JIANG, Yutong; KERCHER, Timothy; KOLAKOWSKI, Gabrielle, R.; THOMAS, Allen, A.; WINSKI, Shannon, L.; WO2014/78454; (2014); A1;,
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Brief introduction of 910251-11-5

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Potassium trifluoro(methoxymethyl)borate, other downstream synthetic routes, hurry up and to see.

Synthetic Route of 910251-11-5, The chemical industry reduces the impact on the environment during synthesis 910251-11-5, name is Potassium trifluoro(methoxymethyl)borate, I believe this compound will play a more active role in future production and life.

4-Fluoro-2-(4-fluorophenyl)-5-isopropoxy-6-(methoxymethyl)-N- methylbenzofuran-3-carboxamide A mixture of 6-bromo-4-fluoro-2-(4-fluorophenyl)-5-isopropoxy-N- methylbenzofuran-3-carboxamide (600 mg, 1.414 mmol) , potassium methoxymethyltrifluoroborate (2149 mg, 14.14 mmol), PdCl2(dppf) (310 mg, 0.424 mmol) and cesium carbonate (2074 mg, 6.36 mmol) in a mixture of toluene (60 mL) and water (20 ml) was flushed with N2 and then stirred at 85C for 48 hrs. The mixture was diluted wih EtOAc (200 mL). The water layer was removed. The organic layer was filtered and then concentrated to give a crude solid, which was purified by column chromatography (Biotage 25m, EtOAc/Hexane = 0 to 30%) to give 280 mg (51 %) of the product as a white solid. 1H NMR (400 MHz, CHLOROFORM-d) delta 7.99 – 7.92 (m, 2H), 7.41 (s, 1H), 7.21 – 7.13 (m, 2H), 6.12 (br. s., 1H), 4.62 (d, J=0.5 Hz, 2H), 4.56 – 4.47 (m, 1H), 3.51 – 3.47 (m, 3H), 3.07 (d, J=5.0 Hz, 3H), 1.37 (m, 6H). LCMS R, = 3.151 min., m/z 390 (M + H). The LC/MS data was obtained on a Shimadzu analytical LC /Micromass Platform LC (ESI+) at 220nm using the following set of conditions: Phenomenex Luna 3muiotaeta C18, 2 x 50 mm column, with a gradient of 0-100%B (B = 90% HPLC grade acetonitrile/ 0.1% trifluoro acetic acid/ 10% HPLC grade water), (A = 90% HPLC grade water / 0.1% trifluoroacetic acid/ 10% HPLC grade acetonitrile), in 4 minutes with a 1 minute hold at a rate of 0.8 mL/minute.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Potassium trifluoro(methoxymethyl)borate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; YEUNG, Kap-Sun; EASTMAN, Kyle J.; PARCELLA, Kyle E.; WO2014/159559; (2014); A1;,
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The important role of C2H5BF3KO

The synthetic route of 910251-11-5 has been constantly updated, and we look forward to future research findings.

Related Products of 910251-11-5, A common heterocyclic compound, 910251-11-5, name is Potassium trifluoro(methoxymethyl)borate, molecular formula is C2H5BF3KO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

j0288j Combined 3 -chloro-6-(4-(2,4-difluorophenoxy)piperidin- l-yl)-5-(isopropylamino)pyrazine-2-carbonitrile (50 mg, 0.123 mmol), PdC12(dppf) (8.97 mg, 0.0 12 mmol), potassium methoxymethyltrifluoroborate (74.5 mg, 0.490 mmol) and 2N Na2CO3 (0.5 ml) in dioxane (1.0 mL). The reaction mixture was heated in a microwave at 130 C for 30 mm. The reaction mixture was filtered and purified by HPLC using Method A twice to afford the title compound as its TFA salt (6 mg, 10%) as a yellow film. 1H NMR (500 MHz, methanol-d4) ppm 1.27 (d, J=6.35 Hz, 6 H) 1.87 – 2.04 (m, 2 H) 2.08 – 2.20 (m, 2 H) 3.05 (ddd, J=12.45, 8.54, 3.42 Hz, 2 H) 3.37 – 3.50 (m, 2 H) 4.28 – 4.41 (m, 1 H) 4.43 – 4.53 (m, 3 H) 6.80 – 6.93 (m, 1 H) 6.98 (ddd, J=11.35, 8.66, 2.93 Hz, 1 H) 7.17 (td, J=9.28, 5.37 Hz, 1 H) ; ESI-MS mlz [M+H]+ 418.4.

The synthetic route of 910251-11-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; ADAMS, Mark E.; BROWN, Jason W.; HITCHCOCK, Stephen; HOPKINS, Maria; KIKUCHI, Shota; LAM, Betty; MONENSCHEIN, Holger; REICHARD, Holly; SUN, Huikai; WO2015/123533; (2015); A1;,
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Share a compound : C2H5BF3KO

The synthetic route of Potassium trifluoro(methoxymethyl)borate has been constantly updated, and we look forward to future research findings.

Electric Literature of 910251-11-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 910251-11-5, name is Potassium trifluoro(methoxymethyl)borate belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Methyl (R)-12′-(benzyloxy)-H’-chloro-8′-oxo- ,2′,8′,13b’-tetrahydrospiro[cyclopropane-l,3′- pyrido[2,l-a]pyrrolo[l,2-c]phthalazine]-7′-carboxylate (234 mg, 0.51 mmol) was dissolved in isopropanol (10 mL) with 2 drops of acetic acid. The mixture was stirred at reflux for 2.5 hours, then cooled to room temperature to provide isopropyl (R)-12′-(benzyloxy)-H’-chloro-8′-oxo- ,2′,8′,13b’-tetrahydrospiro[cyclopropane-l,3′-pyrido[2,l-a]pyrrolo[l,2-c]phthalazine]-7′- carboxylate. MS (m/z) 491.3 [M+H]+. The crude ester was combined with (0993) trifluoro(methoxymethyl)-borane, potassium salt (230 mg, 1.52 mmol), Pd RuPhos G4 (52 mg, 0.061 mmol), RuPhos (42 mg, 0.091 mmol), and cesium carbonate (823 mg, 2.53 mmol) in toluene:water (3: 1, 5 mL) under argon in a sealed vial. The mixture was heated at 110 C for 45 minutes with vigorous stirring, then cooled to room temperature, the aqueous layer was removed, and the organics were concentrated in vacuo and purified by flash column (0994) chromatography (hexanes / ethyl acetate / ethanol / triethylamine) to provide isopropyl (R)-12′- (benzyloxy)-i -(methoxymethyl)-8′-oxo- ,2′,8′,13b’-tetrahydrospiro[cyclopropane-l,3′- pyrido[2,l-a]pyrrolo[l,2-c]phthalazine]-7′-carboxylate. MS (m/z) 501.4 [M+H]+.

The synthetic route of Potassium trifluoro(methoxymethyl)borate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GILEAD SCIENCES, INC.; AKTOUDIANAKIS, Evangelos; CANALES, Eda; CURRIE, Kevin S.; KATO, Darryl; LI, Jiayao; LINK, John O.; METOBO, Samuel E.; SAITO, Roland D.; SCHROEDER, Scott D.; SHAPIRO, Nathan; TSE, Winston C.; WU, Qiaoyin; (262 pag.)WO2018/144605; (2018); A1;,
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Simple exploration of 910251-11-5

According to the analysis of related databases, 910251-11-5, the application of this compound in the production field has become more and more popular.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 910251-11-5, name is Potassium trifluoro(methoxymethyl)borate, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C2H5BF3KO

Intermediate 52a 6-chloro-3-(methoxymethyI)-l-trityl-lH-pyrazolo[43-c]pyridine Under Argon, the solution of 6-cUoro-3-iodo-l-trityl-lH-pyrazolot4,3-c]pyridine (52 mg, 0.100 mmol), potassium methoxymethyltrifluoroborate (16.66 mg, 0.110 mmol), palladium(n) acetate (0.671 mg, 2.99 mupiiotaomicron), (2-DICYCLOHEXYLPHOSPfflNO-2′,6′- DIISOPROPYL-l,l’-BIPHENYL)[2-(2-AMINOETHYL)PHENYL)]PALLADIUM(n) (4.36 mg, 5.98 mol) and cesium carbonate (0.024 ml, 0.299 mmol) in 1,4-Dioxane (0.9 ml) and Water (0.1 ml) was allowed to stir at 100 C for 24h. LC-MS showed the desired product’s mass. EtOAc was added into the mixture and the organic layer was washed by water and brine. After drying over Na2S04 the organic layer was evaporated under reduced pressure yielding 6- c oro-3-(memoxymethyl)-l-1rityl-lH-pyrazolo[4,3-c]pyridine, 52a. The intermediate was taken to the next reaction without further purification. MS ESI Calc’d for C27H22CIN3O [M+H]+ 440, found 440.

According to the analysis of related databases, 910251-11-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; MERCK SHARP & DOHME CORP.; LIM, Jongwon; KELLEY, Elizabeth Helen; METHOT, Joey, L.; ZHOU, Hua; PETROCCHI, Alessia; MANSOOR, Umar Faruk; FISCHER, Christian; O’BOYLE, Brendan, M.; GUERIN, David Joseph; BIENSTOCK, Corey, E.; BOYCE, Christopher, W.; DANIELS, Matthew, H.; FALCONE, Danielle; FERGUSON, Ronald, D., II; FEVRIER, Salem; HUANG, Xianhai; LIPFORD, Kathryn Ann; SLOMAN, David, L.; WILSON, Kevin; ZHOU, Wei; WITTER, David; MALETIC, Milana, M.; SILIPHAIVANH, Phieng; WO2013/63214; (2013); A1;,
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Analyzing the synthesis route of 910251-11-5

The chemical industry reduces the impact on the environment during synthesis Potassium trifluoro(methoxymethyl)borate. I believe this compound will play a more active role in future production and life.

Related Products of 910251-11-5, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 910251-11-5, name is Potassium trifluoro(methoxymethyl)borate, This compound has unique chemical properties. The synthetic route is as follows.

Example 33 Synthesis of rac-1-((1R,2R)-2-hydroxy-7-(methoxy methyl)-4,4-dimethyl-1,2,3,4-tetrahydronaphthalen-1-yl)-3-(5-methyl-2-(tetrahydro-2H-pyran-4-yl)pyridin-3-yl)urea A crude product (82 mg) of rac-1-((1R,2R)-7-bromo-2-hydroxy-4,4-dimethyl-1,2,3,4-tetrahydronaphthalen-1-yl)-3-(5-methyl-2-(tetrahydro-2H-pyran-4-yl)pyridin-3-yl)urea was obtained from the compound (63 mg) obtained in (Example 26) and the compound (50 mg) obtained in (Example 32) in the same method as in (Example 2) . Tris(dibenzylideneacetone)dipalladium (0) (34 mg), 2-dicyclohexylphosphino-2′,6′-diisopropoxy-1,1′-biphenyl (35 mg), potassium (methoxymethyl) trifluoroborate (0.14 g), cesium carbonate (0.24 g), 1,4-dioxane (1.0 mL), and water (0.25 mL) were added to this crude product (82 mg), and after purging with nitrogen by degassing under reduced pressure, the mixture was stirred at 110 C. for 15 hours. The reaction solution was filtered, and the filtrate was purified by preparative LC-Mass to obtain the title compound (12 mg).

The chemical industry reduces the impact on the environment during synthesis Potassium trifluoro(methoxymethyl)borate. I believe this compound will play a more active role in future production and life.

Reference:
Patent; MOCHIDA PHARMACEUTICAL CO., LTD.; SAITOH, Fumihiko; NAGASUE, Hiroshi; (124 pag.)US2019/23657; (2019); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Some tips on C2H5BF3KO

The synthetic route of 910251-11-5 has been constantly updated, and we look forward to future research findings.

910251-11-5, name is Potassium trifluoro(methoxymethyl)borate, belongs to ethers-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Safety of Potassium trifluoro(methoxymethyl)borate

Under an argon atmosphere a mixture of 70 mg of tert-butyl 10-bromo-8-cyclopropyl-3,4,7,8-tetrahydro-1H-[1,4]diazepino[6,7,1-ij]quinoline-2(6H)-carboxylate (0.172 mmol, 1.00 eq) from step 8.2, 52.2 mg of potassium trifluoro (2-methoxymethyl)borate (0.344 mmol, 2.00 eq), 168 mg of cesium carbonate (0.516 mmol, 3.00 eq), 1.43 mg of Pd(OAc)2 (0.006 mmol, 0.04 eq) and 5.73 mg of X-Phos (0.012 mmol, 0.07 eq) in degassed dioxane (4 mL) and water (0.5 mL) was heated in a microwave at 130 C. for 40 h. Then the mixture was extracted with DCM and the organic phase was washed with water and dried over MgSO4, filtrated and solvent was evaporated to yield the title compound. ESI-MS: m/z (%): 373.30 (100, [M+H]+).

The synthetic route of 910251-11-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; AbbVie Deutschland GmbH & Co. KG; BACKFISCH, Gisela; BAKKER, Margaretha Henrica Maria; BLAICH, Guenter; BRAJE, Wilfried; DRESCHER, Karla; ERHARD, Thomas; HAUPT, Andreas; KOOLMAN, Hannes; LAKICS, Viktor; LINSENMEIER, Anna; MACK, Helmut; PETER, Raimund; RELO, Ana Lucia; US2015/259343; (2015); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Discovery of Potassium trifluoro(methoxymethyl)borate

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Potassium trifluoro(methoxymethyl)borate, other downstream synthetic routes, hurry up and to see.

Synthetic Route of 910251-11-5, The chemical industry reduces the impact on the environment during synthesis 910251-11-5, name is Potassium trifluoro(methoxymethyl)borate, I believe this compound will play a more active role in future production and life.

A vial was charged with (8-bromo-5,ll -dihydro-6H-pyrido [2,3-b] [1,5 ]benzodiazepin-6- yl)Qrans-4-methoxycyclohexyl)methanone (25 mg, 0.060 mmol), potassium trifluoro(methoxymethyl)borate (11 mg, 0.075 mmol), mesylate[(di( 1 -adamantyl)-nbutylphosphine)-2-(2?-amino- 1,1 ?-biphenyl)]palladium(II), [(di( 1 -adamantyl)-butylphosphine)-2- (2?-amino-l,l?-biphenyl)]palladium(II) methanesulfonate (4.4 mg, 6.0 jimol) and cesiumcarbonate (59 mg, 0.18 mmol). The solids were dissolved in 2-methyl-2-butanol (0.5 mL) andwater (0.125 mL), the reaction was purged under argon for 5 minutes, and then heated to 70C for 18 h. The reaction was then allowed to cool to room temperature and concentrated under reduced pressure. The residue was filtered and purified by mass triggered reverse phase HPLC (ACN/water with 0.1% TFA modifier) to afford the title compound as a solid TFA salt. MS: 382 (M + 1). ?H NMR (600 MHz, DMSO-d6) oe 9.61 (s, 1H), 8.04 – 8.00 (m, 1H), 7.51 (d, J= 7.1 Hz,1H),7.29-7.26(m, 1H),7.19-7.16(m,2H),6.76-6.71 (m, 1H),5.17 (d,J= 15.0Hz, 1H),4.33 (s, 2H), 3.88 (d, J 14.9 Hz, 1H), 3.20 (s, 3H), 3.09 (s, 3H), 2.95 – 2.85 (m, 1H), 2.38 -2.31 (m, 1H), 1.98-1.90 (m, 1H), 1.84- 1.79 (m, 1H), 1.76- 1.70 (m, 1H), 1.48-1.37 (m,1H), 1.17- 1.08 (m, 1H), 0.99 -0.90 (m, 1H), 0.86- 0.76 (m, 1H), 0.62- 0.51 (m, 1H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Potassium trifluoro(methoxymethyl)borate, other downstream synthetic routes, hurry up and to see.

Sources of common compounds: Potassium trifluoro(methoxymethyl)borate

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Potassium trifluoro(methoxymethyl)borate, and friends who are interested can also refer to it.

Reference of 910251-11-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 910251-11-5 name is Potassium trifluoro(methoxymethyl)borate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A vessel was charged with 4-[[2-(3-bromophenyl)acetyljaminoj-N-tert-butyl-pyridine-2- carboxamide (Example 54 step 1)(50 mg, 0.13 mmol) PdCl2dppf (3 mg), potassium trifluoro(methoxymethyl)boranuide (0.45 mL, 0.26 mmol) 2M aq. sodium carbonate (0.26mL, 0.51 mmol) and heated at8O Cfor 16 hours. The mixture was allowed to cool to room temperature, poured onto water (20 mL) and extracted into EtOAc (3 x 20 mL). The combined organic extracts were washed with brine (50 mL), dried over Na2504 and concentrated in vacuo. The residue was dissolved in DMSO:MeCN (800 p1, 1:1), filtered and purified by preparative HPLC (acidic pH, early elution method) to afford the titledcompound as an off-white solid.1H NMR (500 MHz, DMSO-d6) O 10.76 (5, 1H), 8.44 (d, J = 5.5 Hz, 1H), 8.18 (d, J = 2.1Hz, 1H), 8.02 (5, 1H), 7.81 (dd, J = 5.5, 2.2 Hz, 1H), 7.34-7.27 (m, 2H), 7.25 (d, J = 7.7Hz, 1H), 7.20 (d, J = 7.5 Hz, 1H), 4.40 (5, 2H), 3.71 (5, 2H), 3.29 (5, 3H), 1.39 (5, 9H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Potassium trifluoro(methoxymethyl)borate, and friends who are interested can also refer to it.