Synthetic Route of 910251-11-5, The chemical industry reduces the impact on the environment during synthesis 910251-11-5, name is Potassium trifluoro(methoxymethyl)borate, I believe this compound will play a more active role in future production and life.
A vial was charged with (8-bromo-5,ll -dihydro-6H-pyrido [2,3-b] [1,5 ]benzodiazepin-6- yl)Qrans-4-methoxycyclohexyl)methanone (25 mg, 0.060 mmol), potassium trifluoro(methoxymethyl)borate (11 mg, 0.075 mmol), mesylate[(di( 1 -adamantyl)-nbutylphosphine)-2-(2?-amino- 1,1 ?-biphenyl)]palladium(II), [(di( 1 -adamantyl)-butylphosphine)-2- (2?-amino-l,l?-biphenyl)]palladium(II) methanesulfonate (4.4 mg, 6.0 jimol) and cesiumcarbonate (59 mg, 0.18 mmol). The solids were dissolved in 2-methyl-2-butanol (0.5 mL) andwater (0.125 mL), the reaction was purged under argon for 5 minutes, and then heated to 70C for 18 h. The reaction was then allowed to cool to room temperature and concentrated under reduced pressure. The residue was filtered and purified by mass triggered reverse phase HPLC (ACN/water with 0.1% TFA modifier) to afford the title compound as a solid TFA salt. MS: 382 (M + 1). ?H NMR (600 MHz, DMSO-d6) oe 9.61 (s, 1H), 8.04 – 8.00 (m, 1H), 7.51 (d, J= 7.1 Hz,1H),7.29-7.26(m, 1H),7.19-7.16(m,2H),6.76-6.71 (m, 1H),5.17 (d,J= 15.0Hz, 1H),4.33 (s, 2H), 3.88 (d, J 14.9 Hz, 1H), 3.20 (s, 3H), 3.09 (s, 3H), 2.95 – 2.85 (m, 1H), 2.38 -2.31 (m, 1H), 1.98-1.90 (m, 1H), 1.84- 1.79 (m, 1H), 1.76- 1.70 (m, 1H), 1.48-1.37 (m,1H), 1.17- 1.08 (m, 1H), 0.99 -0.90 (m, 1H), 0.86- 0.76 (m, 1H), 0.62- 0.51 (m, 1H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Potassium trifluoro(methoxymethyl)borate, other downstream synthetic routes, hurry up and to see.