Related Products of 33170-72-8, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 33170-72-8 as follows.
[0322] To a stirred solution of iV-hydroxy-6-methoxy-5-(4-methyl- 1H-imidazol- 1-yl) picolinimidamide (1 g, 4 mmol) in DMSO (5 mL) at 0 C under an argon atmosphere were added potassium hydroxide (272 mg, 5 mmol) and 2-bromo-1,1-dimethoxypropane (814 mg, 4 mmol). The reaction mixture was warmed to room temperature and stirred for 24 h. After consumption of the starting material (monitored by TLC), the reaction mixture was diluted with ice cold water (30 mL) and extracted with EtOAc (2 x 30 mL). The combined organic extracts were dried over sodium sulfate, filtered and concentrated in vacuo to obtain N-((1,1- dimethoxypropan-2-yl) oxy)-6-methoxy-5-(4-methyl- 1 H-imidazol- 1 -yl) picolinimidamide Example 3 (300 mg, crude) as an off-white solid used in the next step without further purification. LCMS: 46.2%; 349.9 (M+1); (column; Ascentis Express C-18 (50 x 3.0 mm, 2.7tim); RT 1.63 mm; mobile phase: 0.025% Aq TFA+5% ACN: ACN+5% 0.025% Aq TFA; T/B%: 0.01/5, 0.5/5, 3/100, 5/100; flow rate: 1.2 mL/min) (Gradient); TLC: 30% EtOAc/ hexane (Rj: 0.6)
According to the analysis of related databases, 33170-72-8, the application of this compound in the production field has become more and more popular.