Electric Literature of 910251-11-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 910251-11-5, name is Potassium trifluoro(methoxymethyl)borate belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Methyl (R)-12′-(benzyloxy)-H’-chloro-8′-oxo- ,2′,8′,13b’-tetrahydrospiro[cyclopropane-l,3′- pyrido[2,l-a]pyrrolo[l,2-c]phthalazine]-7′-carboxylate (234 mg, 0.51 mmol) was dissolved in isopropanol (10 mL) with 2 drops of acetic acid. The mixture was stirred at reflux for 2.5 hours, then cooled to room temperature to provide isopropyl (R)-12′-(benzyloxy)-H’-chloro-8′-oxo- ,2′,8′,13b’-tetrahydrospiro[cyclopropane-l,3′-pyrido[2,l-a]pyrrolo[l,2-c]phthalazine]-7′- carboxylate. MS (m/z) 491.3 [M+H]+. The crude ester was combined with (0993) trifluoro(methoxymethyl)-borane, potassium salt (230 mg, 1.52 mmol), Pd RuPhos G4 (52 mg, 0.061 mmol), RuPhos (42 mg, 0.091 mmol), and cesium carbonate (823 mg, 2.53 mmol) in toluene:water (3: 1, 5 mL) under argon in a sealed vial. The mixture was heated at 110 C for 45 minutes with vigorous stirring, then cooled to room temperature, the aqueous layer was removed, and the organics were concentrated in vacuo and purified by flash column (0994) chromatography (hexanes / ethyl acetate / ethanol / triethylamine) to provide isopropyl (R)-12′- (benzyloxy)-i -(methoxymethyl)-8′-oxo- ,2′,8′,13b’-tetrahydrospiro[cyclopropane-l,3′- pyrido[2,l-a]pyrrolo[l,2-c]phthalazine]-7′-carboxylate. MS (m/z) 501.4 [M+H]+.
The synthetic route of Potassium trifluoro(methoxymethyl)borate has been constantly updated, and we look forward to future research findings.
Reference:
Patent; GILEAD SCIENCES, INC.; AKTOUDIANAKIS, Evangelos; CANALES, Eda; CURRIE, Kevin S.; KATO, Darryl; LI, Jiayao; LINK, John O.; METOBO, Samuel E.; SAITO, Roland D.; SCHROEDER, Scott D.; SHAPIRO, Nathan; TSE, Winston C.; WU, Qiaoyin; (262 pag.)WO2018/144605; (2018); A1;,
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