Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 41406-00-2, name is 3-Isopropoxyaniline, A new synthetic method of this compound is introduced below., name: 3-Isopropoxyaniline
A mixture of 2,4-dichloro-5-methylpyrimidine (0.326 g, 2.0 mmol), 3-isopropoxyaniline (0.310 mL, 2.1 mmol), DIPEA (0.420 mL, 2.4 mmol), and iPrOH (2 mL) was allowed to react and worked up following the same procedure used to make RJ1-048, with the exception that no MeOH was added before workup and that the reaction was run overnight for 19.5 hours. The residue was then purified via flash chromatography, and the desired product RJl-058 was collected at hexanes/EtOAc 15-20% as a flaky caramel-colored solid (0.242 g, 44%). m.p. = 127 – 128 C. NMR (400 MHz, DMSO-ifc) delta 8.76 (s, 1H), 8.03 (s, 1H), 7.30 (t, / = 2.2 Hz, 1H), 7.25-7.13 (m, 2H), 6.64 (ddd, / = 8.0, 2.4, 1.1 Hz, 1H), 4.59^.50 (m, 1H), 2.15 (d, / = 0.6 Hz, 3H), 1.27 (d, / = 6.0 Hz, 6H). LRMS (ESI+) m/z 278.1 (M35C1+H)+, 280.1 (M37C1+H)+; HRMS (ESI+) m/z calculated for CwHieClNsO (M+H)+ 278.10547, found 278.10860.
The synthetic route of 41406-00-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; H. LEE MOFFITT CANCER CENTER & RESEARCH INSTITUTE, INC.; SCHOeNBRUNN, Ernst; LAWRENCE, Nicholas J.; LAWRENCE, Harshani R.; (293 pag.)WO2017/66428; (2017); A1;,
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