Related Products of 104-92-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 104-92-7 name is 1-Bromo-4-methoxybenzene, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
General procedure: n-BuLi (1.2 mmol) was added to a THF (6 ml) solution ofaryl bromide (1 mmol) at -78C. After stirring for 1 h at same temperature, a THF solution of MOM-Cl or BOM-Cl (1.1 mmolin 4 ml dry THF) was added dropwise to it. Stirring was continuedfor another 1 h at same temperature and slowlywarmed to 0C over another 1 h and quenched with saturatedaqueous ammonium chloride solution. The organic layerwas separated and aqueous layer was extracted with diethylether. The combined organic layer was dried (Na2SO4) andevaporated. Column chromatographic purification gave thedesired product.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Bromo-4-methoxybenzene, and friends who are interested can also refer to it.
Reference:
Article; Panda, Biswajit; Journal of the Indian Chemical Society; vol. 95; 8; (2018); p. 981 – 985;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem