Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 104-92-7, name is 1-Bromo-4-methoxybenzene, A new synthetic method of this compound is introduced below., Application In Synthesis of 1-Bromo-4-methoxybenzene
General procedure: A mixture of Ni(cod)2 (0.050 mmol), SIPr·HCl (0.050 mmol),KOt-Bu (0.050 mmol), and CPME was stirred at 100 C for 30min. To this was added NaOAc (0.85 mmol), aryl bromide 1(0.50 mmol), and N-TMS-carbazole 2 (0.65 mmol). The reactionmixture was quenched with H2O. The aqueous layer wasextracted with Et2O and washed with brine. The combinedorganic layers were dried over anhydrous MgSO4. After concentrationin vacuo, the residue was purified by flash chromatographyon silica gel or preparative TLC to afford N-aryl-carbazoles 3.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Minami, Yasunori; Komiyama, Takeshi; Shimizu, Kenta; Uno, Shu-Ichi; Hiyama, Tamejiro; Goto, Osamu; Ikehira, Hideyuki; Synlett; vol. 28; 18; (2017); p. 2407 – 2410;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem