Related Products of 446-59-3, A common heterocyclic compound, 446-59-3, name is 2-Bromo-1-fluoro-3-methoxybenzene, molecular formula is C7H6BrFO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To the dried reaction flask was added magnesium dust (600 mg, 24.9 mmol), a small portion of iodine and anhydrous tetrahydrofuran (10 mL), and the reflux condenser was charged and protected with nitrogen. -methoxybenzene (0.5 g) followed by the addition of 2-bromo-1-fluoro-3-methoxybenzene (2.5 g, 12.2 mmol) and freshly distilled 1,3-cyclopentadiene (1.05 g, 17.56 mmol) was dissolved in anhydrous tetrahydrofuran (20 mL) and placed in a constant pressure dropping funnel to slowly dropwise and the reaction system was kept slightly refluxed. After completion of the dropwise addition, the reaction system was heated to reflux for 1 hour. The reaction was quenched with saturated aqueous ammonium chloride (10 mL) and extracted with ethyl acetate (60 mL x 2). The organic phase was washed with saturated brine (30 mL) and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure and the crude product was purified by silica gel column chromatography (eluted with petroleum ether) to give the title compound (1.43 g, 56%) as a colorless liquid
The synthetic route of 446-59-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Dongguan Dongyangguang Pharmaceutical Research And Development Co., Ltd.; Zhou Pingjian; Wang Xiaojun; Yang Chuanwen; Lin Jihua; Cao Shengtian; Yang Xinye; Zhang Yingjun; (34 pag.)CN106916091; (2017); A;,
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