Reference of 1978-39-8, The chemical industry reduces the impact on the environment during synthesis 1978-39-8, name is 5-Fluoro-2-methoxyaniline, I believe this compound will play a more active role in future production and life.
Step (c): Preparation of 1-(3-fluoro-6-methoxyphenyl)piperazine 5-fluoro-2-methoxyaniline (0.092 mol) and bis(2-chloroethyl)aminehydrochloride (0.1 mol) in xylene (300 ml) was refluxed with stirring for a period of 20 hrs. Water was added to the reaction and the organic layer discarded. The aqueous layer was basified with sodium hydroxide and extracted with methylene chloride (2*100 ml). The methylene chloride extract was dried (sodium carbonate), filtered, and concentrated. Residual material was distilled to provide 8.8 g (45% yield) of piperazine product, b.p. 111-114 C. 0.15 mmHg:
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Fluoro-2-methoxyaniline, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Bristol-Myers Company; US4585773; (1986); A;,
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