These common heterocyclic compound, 1978-39-8, name is 5-Fluoro-2-methoxyaniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: 5-Fluoro-2-methoxyaniline
Step (b): Preparation of 1-(4-fluoro-2-methoxyphenyl)piperazine Reaction of bis(2-chloroethyl)amine hydrochloride (0.11 mol) with 5-fluoro-2-methoxyaniline (0.01 mol) according to Step (c) of Example XII, provided 19.5 g (95% yield) of the piperazine intermediate used without further purification.
The synthetic route of 5-Fluoro-2-methoxyaniline has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Bristol-Myers Company; US4585773; (1986); A;,
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