Some common heterocyclic compound, 801282-00-8, name is 2-Fluoro-3-methoxyaniline, molecular formula is C7H8FNO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 2-Fluoro-3-methoxyaniline
Aniline D3 (1.18 g, 8.36 MMOL) was combined with dimethylacetylene dicarboxylate A3 (1.45 mL, 10.0 MMOL) in methanol (25 mL). The reaction was REFLUXED for 2 hours before being concentrated to dryness. The crude material was purified by flash chromatography eluting with 9/1 (hexane/EtOAc) to give the Michael adduct D4 as a yellow oil, (1. 27 g, 54%)
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 801282-00-8, its application will become more common.
Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH & CO KG; WO2004/103996; (2004); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem