Related Products of 1978-39-8,Some common heterocyclic compound, 1978-39-8, name is 5-Fluoro-2-methoxyaniline, molecular formula is C7H8FNO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Example 2 (5) obtained in 2 – [[5- (4-hydroxy-3-methoxyphenyl)-4-(lH-pyrrol-1-yl)-4H-1,2,4-triazole -3 – yl] thio] acetic acid (200mg, 0.58mmol),1-hydroxybenzotriazole (80mg, 0.6mmol),1-ethyl-3- (3-dimethylaminopropyl) carbodiimide hydrochloride (120 mg, 0.6 mmol)Of N, N-dimethylformamide (4 ml)Was added triethylamine (0.18ml, 1.2mmol)When the 5-fluoro-2-methoxy aniline (0.08ml, 0.7mmol)Was stirred for 16 hours at room temperature added.It was extracted by the addition of 1N hydrochloric acid and ethyl acetate to the reaction solution. Further, the aqueous layer was extracted twice with ethyl acetate, the organic layer was dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure, the residue was purified by column (hexane: ethyl acetate = 1: 3-1: 5) to give N-(5-fluoro-2-methoxyphenyl) -2 – [[5- ( 4-hydroxy-3-methoxyphenyl) -4- (1H- pyrrol-1-yl) -4H-1,2,4- triazol-3-yl] thio] acetamide (30mg, 11%) a pale brown solid It was obtained as a.
The synthetic route of 1978-39-8 has been constantly updated, and we look forward to future research findings.