These common heterocyclic compound, 5414-19-7, name is 1-Bromo-2-(2-bromoethoxy)ethane, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 5414-19-7
TERT-BUTYL F [S- (4-BUTOXYPHENYL) thien-2-yl] sulfonyl} acetate (5) from Part C (4.0 g, MW 410.55), 18-CROWN-6 (from Aldrich, 0.5 g, catalytic amount), potassium carbonate (from Aldrich, 5.4 g, MW 138. 21,4. 0 eq), and bis (bromoethyl) ether (from Aldrich, 3.4 g, MW 231.93, 1.5 eq) were slurried in N, N-dimethylformamide (20 ML). The resulting mixture was stirred at 65C for 15 hr. Afterward, the mixture was diluted with water (50 ml) and extracted with ethyl acetate (3x-100 ml). The organics were combined and washed with water (2x), washed with brine (LX), dried over NA2S04, and concentrated for a tan oil. The oil was washed with hexanes and dried to afford tert-butyl-4-{[5-(4-butoxyphenyl) thien-2- yl] SULFONYL} TETRAHYDRO-2H-PYRAN-4-CARBOXYLATE (6) as a tan oil (4.3 g, 91 % YIELD). 1H NMR and LCMS confirmed the presence of the desired compound (6). The”equivalents” above indicate equivalents relative to the charged amount of tert-butyl {[5-(4- butoxyphenyl) thien-2-yl] sulfonyl} acetate.
The synthetic route of 1-Bromo-2-(2-bromoethoxy)ethane has been constantly updated, and we look forward to future research findings.