Synthetic Route of 126-38-5,Some common heterocyclic compound, 126-38-5, name is 1-Bromo-2,2-dimethoxypropane, molecular formula is C5H11BrO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
The compound 4,6-dimethoxypyrimidine-5-carboxamide (500 mg, 2.73 mmol) was suspended in1-bromo-2,2-dimethoxypropane (5 mL),The mixture was heated to 130 C and stirred for 1.5 hours. The reaction was monitored by thin-layer chromatography (PE / EtOAc, v / v, 2/1). After the reaction was completed, the reaction mixture was diluted with ethyl acetate (30 mL). The resulting mixture was washed with water (30 mL) and brine (30 mL), and the organic phase was dried over anhydrous sodium sulfate and concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography (PE / EtOAc (v / v) = 8/1) to give the title compound as a white solid (229 mg, 37.9%).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Bromo-2,2-dimethoxypropane, its application will become more common.