Adding a certain compound to certain chemical reactions, such as: 102503-23-1, name is 1-(2,4-Dimethoxyphenyl)-N-methylmethanamine, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 102503-23-1, HPLC of Formula: C10H15NO2
Sodium hydride (60% in oil, 2.23 g, 55.8 mmol) was washed twice with n-hexane and suspended in THF (180 mL). A solution of 1-(2,4-dimethoxyphenyl)-N-methylmethanamine (9.09 g, 50.2 mmol) in THF (10 mL) was added dropwise to this suspension at 0 C, and then the mixture was stirred at 60 C for 18 h. After cooled to 0 C, a solution of compound 15 (9.64 g, 45.4 mmol) in THF (10 mL) was added dropwise, and then the mixture was stirred at the same temperature for 1 h. Ice-cooled solution of NaCl were added, and the mixture was extracted with EtOAc. The extract was washed successively with a solution of NH4Cl, a solution of NaHCO3, H2O and brine, dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure. The residue was purified by basic silica gel column chromatography (EtOAc) to obtain compound 16 (16.8 g, 99%) as a yellow oil. 1H-NMR (CDCl3) d 2.24 (3H, s), 3.51 (2H, s), 3.54 (2H, s), 3.79 (3H, s), 3.80 (3H, s), 6.45 (1H, s), 6.42-6.50 (1H, m), 6.68 (1H, dd, J = 4.7 Hz, 3.6 Hz), 7.18-7.29 (2H, m), 7.98 (1H, ddd, J = 4.5 Hz, 1.9 Hz, 1.5 Hz), 8.25 (1H, ddd, J = 10.2 Hz, 8.0 Hz, 1.9 Hz), 8.67 (1H, s).
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