Application of 102503-23-1, The chemical industry reduces the impact on the environment during synthesis 102503-23-1, name is 1-(2,4-Dimethoxyphenyl)-N-methylmethanamine, I believe this compound will play a more active role in future production and life.
Vinylmagnesium bromide (17.7 mL of a IN solution in THF, 17.7 mmol) was added to a solution of 5 (2.00 g, 8.84 mmol) in dry THF (30 mL) at 0 C. The brown solution was warmed to r.t. for 1 h then a solution of N-methyl-2,4-dimethoxybenzylamine (4.00 g, 22.0 mmol) in THF (10 mL), and water (10 mL) were added. The solution was stirred at r.t. for 1 h, then partitioned between EtOAc and water. The solution was dried and evaporated to give a brown oil, which was chromatographed. Elution with EtOAc/hexanes gave fore fractions, then elution with EtOAc gave 7 (2.27 g, 68%) as a light yellow oil. 1H NMR (CDC13) delta 7.13 (d, J = 8.9 Hz, 1H), 6.73 (s, 2H), 6.44-6.41 (m, 2H), 3.59 (s, 6H), 3.88 (s, 3H), 3.53 (s, 3H), 3.50 (s, 2H), 3.12 (t, J = 7.0 Hz, 1H), 2.84 (t, J = 7.0 Hz, 2H), 2.26 (s, 3H). Found: [M+H]=375.3
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-(2,4-Dimethoxyphenyl)-N-methylmethanamine, other downstream synthetic routes, hurry up and to see.