38336-04-8, name is 2-(Benzyloxy)-1-ethanamine, belongs to ethers-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. SDS of cas: 38336-04-8
(1) Take 5g of p-fluoronitrobenzene dissolved in 50ml of acetonitrile,5.72 g under ice bath2-benzyloxyethylamine (A) is added to the above solution,Then add 9.5 ml of triethylamine,Reaction at 50C for 8 hours,A yellow clear solution is obtained,The reaction solution was concentrated under reduced pressure,Dissolved in 200 ml of dichloromethaneWash 50 ml of water three timesThe organic phases are combined and dried over anhydrous sodium sulfate.After filtration, spin down to give a crude product.The crude product was purified by column chromatography to give intermediate II 4.5 g as a yellow oil.Yield 48.1%.
The synthetic route of 38336-04-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Tierxi (Nanjing) Pharmaceutical Research And Development Co., Ltd.; Li Yantao; Mao Yu; Zhang Chi; Liu Chun; Cui Xilin; (13 pag.)CN107586291; (2018); A;,
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