In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 38336-04-8 as follows. Recommanded Product: 2-(Benzyloxy)-1-ethanamine
(1) Take 10g of bromonitrobenzene dissolved inIn 50 ml acetonitrile,6.5 g 2-benzyloxyethylamine was added to the above solution under ice bath.Then add 20 ml of triethylamine,Reaction at room temperature for 6 hours,A yellow clear solution is obtained,The reaction solution was concentrated under reduced pressure,Dissolved in 200 ml of dichloromethaneWash 50 ml of water three timesCombine the organic phase,Dry with anhydrous sodium sulfateAfter filtration, spin dry to obtain a crude product.After purifying crude product column chromatography, it will be 10.8Compound II,Yield 91.7%.
According to the analysis of related databases, 38336-04-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Tierxi (Nanjing) Pharmaceutical Research And Development Co., Ltd.; Li Yantao; Mao Yu; Zhang Chi; Liu Chun; Cui Xilin; (13 pag.)CN107586291; (2018); A;,
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