Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 123652-95-9, name is (3-Fluoro-4-methoxyphenyl)methanamine, A new synthetic method of this compound is introduced below., Formula: C8H10FNO
General procedure: A microvawe vial (ovendried and under argon) was chargedwith the corresponding bromoindazole derivative (1.0 equiv.), theappropriate amine (1.2 equiv.), Pd(OAc)2 (5 mol%), BrettPhos(10 mol%), Cs2CO3 (1.5 equiv.) and anhydrous dioxane (0.2 mmol/mL). The vial was capped properly, flushed with argon and heatedto 120 C overnight. After cooling, the reaction mixture wasconcentrated under vacuum. The crude residue was diluted withwater and the aqueous phase was extracted 3 times with EtOAc.The organic layers were combined, washed with brine, dried overNa2SO4, filtered, concentrated and purified by silica gel columnchromatography, using the appropriate heptanes:EtOAc mixture.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Bollenbach, Maud; Lugnier, Claire; Kremer, Melanie; Salvat, Eric; Megat, Salim; Bihel, Frederic; Bourguignon, Jean-Jacques; Barrot, Michel; Schmitt, Martine; European Journal of Medicinal Chemistry; vol. 177; (2019); p. 269 – 290;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem